Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Holly L. MacArthur"'
Autor:
Shringi Sharma, Xavier Pepin, Harini Burri, Lianqing Zheng, Nataliya Kuptsova‐Clarkson, Anouk de Jong, Ting Yu, Holly L. MacArthur, Michal Majewski, John C. Byrd, Richard R. Furman, Joseph A. Ware, James Mann, David Ramies, Veerendra Munugalavadla, Louise Sheridan, Helen Tomkinson
Publikováno v:
Clinical pharmacology in drug development. 11(11)
Acalabrutinib is a Bruton tyrosine kinase (BTK) inhibitor approved to treat adults with chronic lymphocytic leukemia, small lymphocytic lymphoma, or previously treated mantle cell lymphoma. As the bioavailability of the acalabrutinib capsule (AC) dep
Autor:
James Mann, Nataliya Kuptsova-Clarkson, Holly L MacArthur, Shringi Sharma, David Ramies, Michal Majewski, Anouk de Jong, Veerendra Munugalavadla, Harini Burri, Helen Tomkinson, Xavier Pepin, Lianqing Zheng, Joseph Ware, Ting Yu, Louise Sheridan
Publikováno v:
Blood. 138:4365-4365
Introduction: Acalabrutinib (Calquence ®), a selective Bruton tyrosine kinase (BTK) inhibitor, is approved for the treatment of mantle cell lymphoma (relapsed/refractory) and chronic lymphocytic leukemia. Patients with hematologic malignancies may r
Autor:
Kirsten L. White, John K Ly, Holly L MacArthur, Michael D. Miller, S. Swaminathan, Nicolas A. Margot, Martin McDermott, James M. Chen, Joy Y. Feng, Adrian S. Ray
Publikováno v:
Antiviral Therapy. 11:155-163
The HIV-1 nucleoside reverse transcriptase inhibitors (NRTIs) tenofovir (TFV), abacavir, didanosine and stavudine can select for K65R, whereas zidovudine (AZT) and stavudine can select for thymidine analogue mutations (TAMs) in HIV-1 reverse transcri
Autor:
John K Ly, Kirsten L. White, Holly L MacArthur, Magdeleine Hung, Nicolas A. Margot, Michael D. Miller
Publikováno v:
Antiviral chemistrychemotherapy. 18(6)
The HIV-1 reverse transcriptase (RT) resistance mutations K65R and M184V occur individually and in combination, and can contribute to decreased treatment responses in patients. In order to understand how these mutations interact with one another to c
Autor:
Holly L MacArthur, Stephanie A. Leavitt, Gregg S. Jones, Manuel Tsiang, Martin J. McDermott, Alice H. Wagner, Xiaohong Liu, Fang Yu, Magdeleine Hung
Publikováno v:
Biochemistry. 46(10)
LEDGF/p75 is known to enhance the integrase strand transfer activity in vitro, but the underlying mechanism is unclear. Using an integrase assay with a chemiluminescent readout adapted to a 96-well plate format, the effect of LEDGF/p75 on both the 3'
Autor:
Martin J. Mcdermott, S. Swaminathan, Ruth Wang, William M. Lee, Holly L MacArthur, Nilima Kutty, Xiaohong Liu, Tomas Cihlar, Craig S. Gibbs, Gabriel Birkus
Publikováno v:
Antimicrobial agents and chemotherapy. 51(2)
GS-7340 and GS-9131 {9-[( R )-2-[[( S )-[[( S )-1-(isopropoxycarbonyl)ethyl]amino]phenoxyphosphinyl]methoxy]-propyl]adenine and 9-( R )-4′-( R )-[[[( S )-1-[(ethoxycarbonyl)ethyl]amino]phenoxyphosphinyl]methoxy]-2′-fluoro-1′-furanyladenine, res
Autor:
Bradford Graves, Choung U. Kim, Xiaowu Chen, Huiwei Wu, Paul A. Escarpe, Willard Lew, Dirk B. Mendel, Holly L. MacArthur
Publikováno v:
ChemInform. 31
As part of our continuing work in the area of influenza neuraminidase inhibitors, a series of C3-aza inhibitors possessing a cyclic amine side chain was synthesized and evaluated for influenza neuraminidase inhibitory activity. Analogues possessing a
Publikováno v:
Somatic cell and molecular genetics. 23(6)
Chromosomal fragile sites are regions that are intrinsically unstable and are susceptible to experimentally induced damage. In most cases, the target and mechanism of induction of fragility are unknown. Using ectopic integration of engineered DNA arr