The innate immune receptor Nlrp12 suppresses autoimmunity to the retina

Autor: Ellen J. Lee, Ruth J. Napier, Emily E. Vance, Sydney J. Lashley, Agnieszka D. Truax, Jenny P. Ting, Holly L. Rosenzweig

Publikováno v: Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-12 (2022)

Abstract Background Nod-like receptors (NLRs) are critical to innate immune activation and induction of adaptive T cell responses. Yet, their role in autoinflammatory diseases of the central nervous system (CNS) remains incompletely defined. The NLR,

Externí odkaz: https://doaj.org/article/3b4bcaf15f1940b58f3ab9e37312b029

T cell-intrinsic role for Nod2 in protection against Th17-mediated uveitis

Autor: Bryce A. Binstadt, João M. Furtado, Michael P. Davey, Paige E. Snow, Biying Xu, Ruth J. Napier, Christina Lancioni, Kimberly A. Samson, Michelle C. Callegan, E. J. Lee, Mary J. Mattapallil, Holly L. Rosenzweig, Emily E. Vance, Sydney Lashley, Reiko Horai, Luke S. Uebelhoer, Brieanna Brown, Rachel R. Caspi, Richard K. Vehe, Justine R. Smith

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Nature Communications

Mutations in nucleotide-binding oligomerization domain-containing protein 2 (NOD2) cause Blau syndrome, an inflammatory disorder characterized by uveitis. The antimicrobial functions of Nod2 are well-established, yet the cellular mechanisms by which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b42c7e920b9a31c5f909265b99df89d
https://doaj.org/article/5c09fe5a329b4c398f56c7642549fe79

Orientia tsutsugamushi selectively stimulates the C-type lectin receptor Mincle and type 1-skewed proinflammatory immune responses

Autor: James Fisher, Brandon Trent, Yuejin Liang, Galen Card, Holly L. Rosenzweig, Lynn Soong

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 7, p e1009782 (2021)

Orientia tsutsugamushi is an obligately intracellular bacterium and the etiological agent of scrub typhus. The lung is a major target organ of infection, displaying type 1-skewed proinflammatory responses. Lung injury and acute respiratory distress s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f58c4199b16c0027c30d582296fc6461
https://pubmed.ncbi.nlm.nih.gov/34320039

T cell intrinsic Nod2 controls Th17 immunity to Candida albicans infection

Autor: Kylie Koney, Sydney J Lashley, Ellen J Lee, Emily E Vance, Dana J Philpott, Jae W Dugan, Michael M Davey, Holly L. Rosenzweig, Ruth J Napier

Publikováno v: The Journal of Immunology. 208:58.08-58.08

We recently discovered a role for Nod2 within T cells in controlling Th17-immunity, such that deletion of Nod2 exacerbated experimental autoimmune arthritis and uveitis. Protection against opportunistic Candida albicans infection relies on intact Th1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::611c9161c54233f270574e62d354411e
https://doi.org/10.4049/jimmunol.208.supp.58.08

Fungal-derived cues promote ocular autoimmunity through a Dectin-2/Card9-mediated mechanism

Autor: Gordon D. Brown, Paige E. Snow, Holly L. Rosenzweig, Xin Lin, E. J. Lee, Emily E. Vance, Naohito Ohno, Christine A. Wells, Yoichiro Iwakura, Noriko Miura, Brieanna Brown, Rachel R. Caspi, Justine R. Smith

Publikováno v: Clinical and Experimental Immunology. 190:293-303

Summary Uveitis (intraocular inflammation) is a leading cause of loss of vision. Although its aetiology is largely speculative, it is thought to arise from complex genetic–environmental interactions that break immune tolerance to generate eye-speci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f418438c0caf981fd941f53f0fe27154
https://doi.org/10.1111/cei.13021