Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Holly Kathleen Emerson"'
Autor:
Erich W. Baum, Brian Wilson, Jason L. Rowand, David E. Uehling, James Michael Salovich, Kelly Anderson, Ganesh S. Moorthy, Stephon C. Smith, M. Anthony Leesnitzer, Robert A. Mook, Kristen Elizabeth Nailor, Kirk L. Stevens, Arthur Groy, Rakesh Kumar, Mui Cheung, Scott Howard Dickerson, Anne M. Hassell, Jingsong Yang, Lisa M. Shewchuk, Roseanne Gerding, Holly Kathleen Emerson, Charity Atkins, Kevin Wayne Kuntz, Peter Sabbatini, Kyle A. Emmitte
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1004-1008
The optimization of imidazo[1,2-a]pyridine inhibitors as potent and selective inhibitors of IGF-1R is presented. Further optimization of oral exposure in mice is also discussed. Detailed selectivity, in vitro activity, and in vivo PK profiles of an o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40ce4aa8f8f52a234e5ce06f2469921a
https://doi.org/10.1016/j.bmcl.2008.11.058
https://doi.org/10.1016/j.bmcl.2008.11.058
Autor:
Alex G. Waterson, Hamilton D. Dickson, Edgar R. Wood, Michael J. Reno, Thomas R. Caferro, Douglas M. Sammond, Tara Renae Rheault, Stanley D. Chamberlain, Barry R. Keith, Holly Kathleen Emerson, Jennifer G. Badiang Alberti, Robert D. Hubbard, Robert J. Griffin, David W. Rusnak, Robert J. Mullin, Krystal J. Alligood, David E. Uehling, Stephon C. Smith, Kimberly G. Petrov, Roseanne Gerding, Scott Howard Dickerson, Kirk L. Stevens
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:21-26
A novel class of pyrrolidinyl-acetyleneic thieno[3,2-d]pyrimidines has been identified which potently inhibit the EGFR and ErbB-2 receptor tyrosine kinases. Synthetic modifications of the pyrrolidine carbamate moiety result in a range of effects on e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b009e9b77f5a50bba3b10df514e6c53b
https://doi.org/10.1016/j.bmcl.2008.11.023
https://doi.org/10.1016/j.bmcl.2008.11.023
Autor:
Victoria B. Knick, Timothy J. Lansing, C. Webb Andrews, Mui Cheung, Kyle A. Emmitte, James Michael Salovich, Hamilton D. Dickson, David H. Drewry, Jennifer Gabriel Badiang, Kristen Elizabeth Nailor, Holly Kathleen Emerson, James A. Linn, Kevin Wayne Kuntz, Robert A. Mook, Ronda G. Davis-Ward, Glenn M. Spehar, Andrea H. Epperly, Daniel F. Hassler
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(3)
The discovery and development of a series of thiophenes as potent and selective inhibitors of PLK is described. Identification and characterization of 2, a useful in vitro PLK inhibitor tool compound, is also presented.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::800cf107edeaf3e8e40e1aad47765499
https://pubmed.ncbi.nlm.nih.gov/19097784
https://pubmed.ncbi.nlm.nih.gov/19097784
Autor:
Michael J. Reno, Alex G. Waterson, David E. Uehling, David W. Rusnak, Robert J. Griffin, Scott Howard Dickerson, Holly Kathleen Emerson, Robert D. Hubbard, Keith R. Hornberger, Edgar R. Wood
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(21)
A novel class of substituted pyrrolidinyl-acetylenic thieno[3,2-d]pyrimidines has been identified that are potent and selective inhibitors of both EGFR/ErbB-2 receptor tyrosine kinases. The inhibitors are found to display a range of enzyme and cellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5167de477e1fbe297fc8b15cf09bfe2f
https://pubmed.ncbi.nlm.nih.gov/18842405
https://pubmed.ncbi.nlm.nih.gov/18842405