Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Holly Janes"'
Autor:
Mia Moore, Yifan Zhu, Ian Hirsch, Tom White, Robert C. Reiner, Ryan M. Barber, David Pigott, James K. Collins, Serena Santoni, Magdalena E. Sobieszczyk, Holly Janes
Publikováno v:
Epidemics, Vol 47, Iss , Pp 100768- (2024)
While rapid development and roll out of COVID-19 vaccines is necessary in a pandemic, the process limits the ability of clinical trials to assess longer-term vaccine efficacy. We leveraged COVID-19 surveillance data in the U.S. to evaluate vaccine ef
Externí odkaz:
https://doaj.org/article/0c1184e721274b25b668765f603565a2
Autor:
Dean Follmann, Meagan P. O’Brien, Jonathan Fintzi, Michael P. Fay, David Montefiori, Allyson Mateja, Gary A. Herman, Andrea T. Hooper, Kenneth C. Turner, Kuo- Chen Chan, Eduardo Forleo-Neto, Flonza Isa, Lindsey R. Baden, Hana M. El Sahly, Holly Janes, Nicole Doria-Rose, Jacqueline Miller, Honghong Zhou, Weiping Dang, David Benkeser, Youyi Fong, Peter B. Gilbert, Mary Marovich, Myron S. Cohen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)
Abstract While new vaccines for SARS-CoV-2 are authorized based on neutralizing antibody (nAb) titer against emerging variants of concern, an analogous pathway does not exist for preventative monoclonal antibodies. In this work, nAb titers were asses
Externí odkaz:
https://doaj.org/article/f53522c4468546fb9a6f21698f892bd1
Publikováno v:
BMC Infectious Diseases, Vol 22, Iss 1, Pp 1-16 (2022)
Abstract Background Despite the development of safe and effective vaccines, effective treatments for COVID-19 disease are still urgently needed. Several antiviral drugs have shown to be effective in reducing progression of COVID-19 disease. Methods I
Externí odkaz:
https://doaj.org/article/93335148b4284c209b953d794b6d69c8
Autor:
Magdalena E. Sobieszczyk, Jill Maaske, Ann R. Falsey, Stephanie Sproule, Merlin L. Robb, Robert W. Frenck Jr., Hong-Van Tieu, Kenneth H. Mayer, Lawrence Corey, Kathleen M. Neuzil, Tina Tong, Margaret Brewinski Isaacs, Holly Janes, Himanshu Bansal, Lindsay M. Edwards, Justin A. Green, Elizabeth J. Kelly, Kathryn Shoemaker, Therese Takas, Tom White, Prakash Bhuyan, Tonya Villafana, and Ian Hirsch, on behalf of the AstraZeneca AZD1222 Clinical Study Group
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 18 (2022)
Background We report updated safety, efficacy, and immunogenicity of AZD1222 (ChAdOx1 nCoV-19) from an ongoing phase 3 trial.Methods Adults at increased risk of SARS-CoV-2 infection were randomized (2:1), stratified by age, to receive 2 doses of AZD1
Externí odkaz:
https://doaj.org/article/0223bfbe518d427787c488021708dfaa
Autor:
David A. Swan, Chloe Bracis, Holly Janes, Mia Moore, Laura Matrajt, Daniel B. Reeves, Eileen Burns, Deborah Donnell, Myron S. Cohen, Joshua T. Schiffer, Dobromir Dimitrov
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Trial results for two COVID-19 vaccines suggest at least 90% efficacy against symptomatic disease (VEDIS). It remains unknown whether this efficacy is mediated by lowering SARS-CoV-2 infection susceptibility (VESUSC) or development of sympto
Externí odkaz:
https://doaj.org/article/2eab7a70fea74c65a94d95d63fb05ed5
Autor:
Laura Matrajt, Julia Eaton, Tiffany Leung, Dobromir Dimitrov, Joshua T. Schiffer, David A. Swan, Holly Janes
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Most COVID-19 vaccines require two doses but a single dose provides partial protection, so it is unclear how best to prioritize vaccine distribution in the context of limited supply. Here, the authors show that campaigns in which some age groups rece
Externí odkaz:
https://doaj.org/article/bfa1b208b6f44b22a73527b76179b75f
Autor:
Rachel A. Bender Ignacio, Jessica Long, Aparajita Saha, Felicia K. Nguyen, Lara Joudeh, Ethan Valinetz, Simon C. Mendelsohn, Thomas J. Scriba, Mark Hatherill, Holly Janes, Gavin Churchyard, Susan Buchbinder, Ann Duerr, Javeed A. Shah, Thomas R. Hawn
Publikováno v:
PLoS ONE, Vol 17, Iss 5 (2022)
Background Although immune activation is associated with HIV acquisition, the nature of inflammatory profiles that increase HIV risk, which may include responses to M. tuberculosis (Mtb) infection, are not well characterized. Methods We conducted a n
Externí odkaz:
https://doaj.org/article/40d7746c9eda499fb12fa9fe7b27ab32
Autor:
Alyssa R. Martin, Eshan U. Patel, Charles Kirby, Jacquie Astemborski, Gregory D. Kirk, Shruti H. Mehta, Kyle Marshall, Holly Janes, Ashley Clayton, Lawrence Corey, Scott M. Hammer, Magdalena E. Sobieszczyk, James Arthos, Claudia Cicala, Andrew D. Redd, Thomas C. Quinn
Publikováno v:
EBioMedicine, Vol 62, Iss , Pp 103102- (2020)
Background: α4β7 is a gut-homing integrin heterodimer that can act as a non-essential binding molecule for HIV. A previous study in heterosexual African women found that individuals with higher proportions of α4β7 expressing CD4+ T cells were mor
Externí odkaz:
https://doaj.org/article/7367fc413a0a4a43b71e47de9af01fb9
Autor:
David A. Swan, Ashish Goyal, Chloe Bracis, Mia Moore, Elizabeth Krantz, Elizabeth Brown, Fabian Cardozo-Ojeda, Daniel B. Reeves, Fei Gao, Peter B. Gilbert, Lawrence Corey, Myron S. Cohen, Holly Janes, Dobromir Dimitrov, Joshua T. Schiffer
Publikováno v:
Viruses, Vol 13, Iss 10, p 1921 (2021)
SARS-CoV-2 vaccine clinical trials assess efficacy against disease (VEDIS), the ability to block symptomatic COVID-19. They only partially discriminate whether VEDIS is mediated by preventing infection completely, which is defined as detection of vir
Externí odkaz:
https://doaj.org/article/aa21e25097ea4b14a5cd7fb29f7f7d42
Autor:
Holly Janes, Marshall D Brown, David V Glidden, Kenneth H Mayer, Susan P Buchbinder, Vanessa M McMahan, Mauro Schechter, Juan Guanira, Martin Casapia
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0222183 (2019)
IntroductionDeveloping guidelines to inform the use of antiretroviral pre-exposure prophylaxis (PrEP) for HIV prevention in resource-limited settings must necessarily be informed by considering the resources and infrastructure needed for PrEP deliver
Externí odkaz:
https://doaj.org/article/8e335fda570043e692ab1ed0cc602769