Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Holly J. Brennan"'
Autor:
Dae-Chul Cho, Holly J. Brennan, Rachelle W. Johnson, Ingrid J. Poulton, Jonathan H. Gooi, Brett A. Tonkin, Narelle E. McGregor, Emma C. Walker, David J. Handelsman, T. J. Martin, Natalie A. Sims
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
The strength of long bones is determined by coalescence of trabeculae during corticalization. Here the authors show that this process is regulated by SOCS3 via a mechanism dependent on IL-6 and expression of sex hormones.
Externí odkaz:
https://doaj.org/article/b957b83bc219453cadc23acf2a9623c9
Autor:
Holly J. Brennan, Dae-Chul Cho, David J. Handelsman, Brett A. Tonkin, Jonathan H. Gooi, Rachelle W. Johnson, Emma C. Walker, Natalie A. Sims, Ingrid J Poulton, T. J. Martin, Narelle E. McGregor
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications
Nature Communications
Long bone strength is determined by its outer shell (cortical bone), which forms by coalescence of thin trabeculae at the metaphysis (corticalization), but the factors that control this process are unknown. Here we show that SOCS3-dependent cytokine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb75050200d4b08da91ca720cdc1d582
https://doaj.org/article/b957b83bc219453cadc23acf2a9623c9
https://doaj.org/article/b957b83bc219453cadc23acf2a9623c9
Autor:
Ingrid J Poulton, Yifang Hu, Nicos A. Nicola, Emma C. Walker, Rachelle W. Johnson, Jian-Guo Zhang, Holly J. Brennan, Natalie A. Sims, Gordon K. Smyth, Brendan J. Jenkins
Publikováno v:
Journal of Biological Chemistry. 291:21703-21716
Oncostatin M (OSM) and leukemia inhibitory factor (LIF) are IL-6 family members with a wide range of biological functions. Human OSM (hOSM) and murine LIF (mLIF) act in mouse cells via a LIF receptor (LIFR)-glycoprotein 130 (gp130) heterodimer. In co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c3296641996bb521d268f3eaeae8ae9
https://doi.org/10.1074/jbc.m116.748483
https://doi.org/10.1074/jbc.m116.748483
Autor:
Christina Vrahnas, Huynh Nguyen, Farzin M. Takyar, Liliana Tatarczuch, Stephen Tonna, Narelle E. McGregor, T. John Martin, Blessing Crimeen-Irwin, Ingrid J Poulton, Eleanor J. Mackie, Mark R. Forwood, Holly J. Brennan, Patricia W. M. Ho, E H Allan, Natalie A. Sims
Publikováno v:
The FASEB Journal. 28:4482-4496
Cells that form bone (osteoblasts) express both ephrinB2 and EphB4, and previous work has shown that pharmacological inhibition of the ephrinB2/EphB4 interaction impairs osteoblast differentiation in vitro and in vivo. The purpose of this study was t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38c8596e5d475138d4aa5522b3a37059
https://doi.org/10.1096/fj.14-254300
https://doi.org/10.1096/fj.14-254300
Autor:
Ingrid J Poulton, Christina Vrahnas, Rachelle W. Johnson, Thuan-Tzen Koh, Huynh Nguyen, Mark R. Forwood, Nicole C. Walsh, Emma C. Walker, Natalie A. Sims, Narelle E. McGregor, Therese Standal, Holly J. Brennan, T. John Martin
Publikováno v:
Journal of Bone and Mineral Research. 29:1492-1505
Interleukin-6 (IL-6) family cytokines act via gp130 in the osteoblast lineage to stimulate the formation of osteoclasts (bone resorbing cells) and the activity of osteoblasts (bone forming cells), and to inhibit expression of the osteocyte protein, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebee05747b59220421f69475c49bb624
https://doi.org/10.1002/jbmr.2159
https://doi.org/10.1002/jbmr.2159
Autor:
Narelle E. McGregor, T. John Martin, Holly J. Brennan, Ingrid J Poulton, Rachelle W. Johnson, Natalie A. Sims, Blessing Crimeen-Irwin
Publikováno v:
Bone. 81
Interleukin-6 (IL-6) and interleukin-11 (IL-11) receptors (IL-6R and IL-11R, respectively) are both expressed in osteoclasts and transduce signal via the glycoprotein130 (gp130) co-receptor, but the physiological role of this pathway is unclear. To d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9c835f1eeb61bf917e6201cd2cf74ef
https://pubmed.ncbi.nlm.nih.gov/26255596
https://pubmed.ncbi.nlm.nih.gov/26255596
Autor:
Rachelle W, Johnson, Holly J, Brennan, Christina, Vrahnas, Ingrid J, Poulton, Narelle E, McGregor, Therese, Standal, Emma C, Walker, Thuan-Tzen, Koh, Huynh, Nguyen, Nicole C, Walsh, Mark R, Forwood, T John, Martin, Natalie A, Sims
Publikováno v:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 29(6)
Interleukin-6 (IL-6) family cytokines act via gp130 in the osteoblast lineage to stimulate the formation of osteoclasts (bone resorbing cells) and the activity of osteoblasts (bone forming cells), and to inhibit expression of the osteocyte protein, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4eb52626c9fd2a8e7d17276d0eb8bd44
https://pubmed.ncbi.nlm.nih.gov/24339143
https://pubmed.ncbi.nlm.nih.gov/24339143
Autor:
Tanja Jovic, Kirby E White, Maria Askmyr, Louise E. Purton, Miralireza Takyar, Emma Baker, Holly J Brennan, Celeste Nota
Publikováno v:
Blood. 114:1447-1447
Abstract 1447 Poster Board I-470 Patients with a range of blood cell diseases are usually treated with myeloablative therapies such as chemotherapy or irradiation accompanied by bone marrow (BM) transplants. These therapies have severe effects on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d151f24160b161e90fea10159ec793e0
https://doi.org/10.1182/blood.v114.22.1447.1447
https://doi.org/10.1182/blood.v114.22.1447.1447