Computational predictions of volatile anesthetic interactions with the microtubule cytoskeleton: implications for side effects of general anesthesia.

Autor: Travis J A Craddock, Marc St George, Holly Freedman, Khaled H Barakat, Sambasivarao Damaraju, Stuart Hameroff, Jack A Tuszynski

Publikováno v: PLoS ONE, Vol 7, Iss 6, p e37251 (2012)

The cytoskeleton is essential to cell morphology, cargo trafficking, and cell division. As the neuronal cytoskeleton is extremely complex, it is no wonder that a startling number of neurodegenerative disorders (including but not limited to Alzheimer'

Externí odkaz: https://doaj.org/article/d6f70744dd134efd8b8fabe6b2c319dc

Machine Learning Approach for Describing Water OH Stretch Vibrations

Autor: Kijeong Kwac, Minhaeng Cho, Holly Freedman

Publikováno v: Journal of chemical theory and computation. 17(10)

A machine learning approach employing neural networks is developed to calculate the vibrational frequency shifts and transition dipole moments of the symmetric and antisymmetric OH stretch vibrations of a water molecule surrounded by water molecules.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd135dae7ad7c96d0fa8e699d9cd392d
https://pubmed.ncbi.nlm.nih.gov/34498885

A Recombinant Hepatitis C Virus Genotype 1a E1/E2 Envelope Glycoprotein Vaccine Elicits Antibodies That Differentially Neutralize Closely Related 2a Strains through Interactions of the N-Terminal Hypervariable Region 1 of E2 with Scavenger Receptor B1

Autor: Janelle Johnson, Darren Hockman, John Lok Man Law, Michael Houghton, D. Lorne Tyrrell, Jason Wong, Holly Freedman, Michael R. Beard, Jianqi He, Thomas F. Baumert, Chao Chen, Michael Logan, Nicholas S. Eyre

Publikováno v: Journal of Virology
Journal of Virology, American Society for Microbiology, 2019, 93 (22), ⟨10.1128/JVI.00810-19⟩
Journal of Virology, 2019, 93 (22), pp.e00810-19. ⟨10.1128/JVI.00810-19⟩

A vaccine is still urgently needed to overcome the hepatitis C virus (HCV) epidemic. It is estimated that 1.75 million new HCV infections occur each year, many of which will go undiagnosed and untreated. Untreated HCV can lead to continued spread of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc9ed9610396a2092674556b7c486488
https://hal.archives-ouvertes.fr/hal-02385651

Structure and Function of the Hepatitis C Virus Envelope Glycoproteins E1 and E2: Antiviral and Vaccine Targets

Autor: Holly Freedman, Michael Logan, John Lok Man Law, Michael Houghton

Publikováno v: ACS Infectious Diseases. 2:749-762

The hepatitis C virus (HCV) envelope glycoproteins E1 and E2 are critical in viral attachment and cell fusion, and studies of these proteins may provide valuable insights into their potential uses in vaccines and antiviral strategies. Progress has in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86a8bfd3dab8845d9e1eb958ec28fcf7
https://doi.org/10.1021/acsinfecdis.6b00110

Computational Prediction of the Heterodimeric and Higher-Order Structure of gpE1/gpE2 Envelope Glycoproteins Encoded by Hepatitis C Virus

Autor: John Lok Man Law, Darren Hockman, Julia Koehler Leman, Michael Logan, Michael Houghton, Holly Freedman

Publikováno v: Journal of Virology. 91

Despite the recent success of newly developed direct-acting antivirals against hepatitis C, the disease continues to be a global health threat due to the lack of diagnosis of most carriers and the high cost of treatment. The heterodimer formed by gly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0df53758a426a27b419f14bc3c612ca
https://doi.org/10.1128/jvi.02309-16