Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Holly Fowle"'
Autor:
Jason S. Wasserman, Holly Fowle, Rumesa Hashmi, Diba Atar, Kishan R. Patel, Amir Yarmahmoodi, Alexander W. Macfarlane, Yinfei Tan, Edna Cukierman, Bojana Gligorijevic, Adam Karami, Kelly A. Whelan, Kerry S. Campbell, Xavier Graña
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Prostate cancer (PCa) is the most common cancer diagnosed in men worldwide and was the second leading cause of cancer-related deaths in US males in 2022. Prostate cancer also represents the second highest cancer mortality disparity between n
Externí odkaz:
https://doaj.org/article/398f3efd1a784589babef813afa2a8f6
Autor:
Jason S. Wasserman, Bulat Faezov, Kishan R. Patel, Alison M. Kurimchak, Seren M. Palacio, David J. Glass, Holly Fowle, Brennan C. McEwan, Qifang Xu, Ziran Zhao, Lauren Cressey, Neil Johnson, James S. Duncan, Arminja N. Kettenbach, Roland L. Dunbrack, Xavier Graña
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The Ser/Thr protein phosphatase 2 A (PP2A) regulates the dephosphorylation of many phosphoproteins. Substrate recognition are mediated by B regulatory subunits. Here, we report the identification of a substrate conserved motif [RK]-V-x-x-[VI
Externí odkaz:
https://doaj.org/article/6e9017a5c5d34b82817862a82164f6a6
Autor:
Jason S. Wasserman, Felicity Feiser, Seren Palacio, Kishan Patel, Joy Gonzalez, Holly Fowle, Xavier Graña
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102148- (2023)
Summary: Serine/threonine protein phosphatase 2 (PP2A) forms heterotrimeric holoenzymes, where a scaffold subunit bridges the PP2A catalytic subunit to a B regulatory subunit, e.g., B55α. The PP2A/B55α holoenzyme plays key roles in signaling and ce
Externí odkaz:
https://doaj.org/article/85f939693b01439dabf9e565d7deac41
Autor:
Holly Fowle, Ziran Zhao, Qifang Xu, Jason S Wasserman, Xinru Wang, Mary Adeyemi, Felicity Feiser, Alison N Kurimchak, Diba Atar, Brennan C McEwan, Arminja N Kettenbach, Rebecca Page, Wolfgang Peti, Roland L Dunbrack, Xavier Graña
Publikováno v:
eLife, Vol 10 (2021)
Protein phosphorylation is a reversible post-translation modification essential in cell signaling. This study addresses a long-standing question as to how the most abundant serine/threonine protein phosphatase 2 (PP2A) holoenzyme, PP2A/B55α, specifi
Externí odkaz:
https://doaj.org/article/6761c6a9c42749159283c5b22082407f
Autor:
Simone Badal, Camille Ragin, Xavier Graña, Yan Zhou, Norman H. Lee, Rory Thompson, Anelia Horvath, Kerry S. Campbell, Fang Jin, Tim Kwok, Wayne McLaughlin, Sharon Harrison, Denise Gibbs, Shannique Clarke, Mark Young, Warren Chin, Elon Thompson, Jason S. Wasserman, Holly Fowle, Ziran Zhao, Belinda Morrison, William Aiken, Henkel Valentine
Prostate cancer cell lines from diverse backgrounds are important to addressing disparities in prostate cancer incidence and mortality rates among Black men. ACRJ-PC28 was developed from a transrectal needle biopsy and established via inactivation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28755a7c6b27cfd88953e56008961bce
https://doi.org/10.1158/2767-9764.c.6550983
https://doi.org/10.1158/2767-9764.c.6550983
Autor:
Simone Badal, Camille Ragin, Xavier Graña, Yan Zhou, Norman H. Lee, Rory Thompson, Anelia Horvath, Kerry S. Campbell, Fang Jin, Tim Kwok, Wayne McLaughlin, Sharon Harrison, Denise Gibbs, Shannique Clarke, Mark Young, Warren Chin, Elon Thompson, Jason S. Wasserman, Holly Fowle, Ziran Zhao, Belinda Morrison, William Aiken, Henkel Valentine
In these prior attempts, culture conditions such as media, extra-cellular matrices and culture flasks were varied to determine the optimal culture conditions for generation of prostate cancer explants.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39e15e06bc4263c9149aae6ec59b3578
https://doi.org/10.1158/2767-9764.22545600.v1
https://doi.org/10.1158/2767-9764.22545600.v1
Autor:
Simone Badal, Camille Ragin, Xavier Graña, Yan Zhou, Norman H. Lee, Rory Thompson, Anelia Horvath, Kerry S. Campbell, Fang Jin, Tim Kwok, Wayne McLaughlin, Sharon Harrison, Denise Gibbs, Shannique Clarke, Mark Young, Warren Chin, Elon Thompson, Jason S. Wasserman, Holly Fowle, Ziran Zhao, Belinda Morrison, William Aiken, Henkel Valentine
Cell viability was determined using the MTS assay and OD readings were taken a 409nm. Plots were generated in Microsoft Excel and each data point represents the average of three replicates. Experiments shown are representative of two independent expe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::104c002ffd8b5b951d6a484b44f466a0
https://doi.org/10.1158/2767-9764.22545606
https://doi.org/10.1158/2767-9764.22545606
Autor:
Simone Badal, Camille Ragin, Xavier Graña, Yan Zhou, Norman H. Lee, Rory Thompson, Anelia Horvath, Kerry S. Campbell, Fang Jin, Tim Kwok, Wayne McLaughlin, Sharon Harrison, Denise Gibbs, Shannique Clarke, Mark Young, Warren Chin, Elon Thompson, Jason S. Wasserman, Holly Fowle, Ziran Zhao, Belinda Morrison, William Aiken, Henkel Valentine
Data from RNA-Seq analysis. Noteworthy were the gene ontologies with a high proportion of expressed genes, such as the nuclear compartment (28%), extracellular exosome compartment (15%), regulation of transcription (8%), apoptotic process (3%) and ox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::294aab620a5c4f01b71272a922abeb54
https://doi.org/10.1158/2767-9764.22545594.v1
https://doi.org/10.1158/2767-9764.22545594.v1
Autor:
Simone Badal, Camille Ragin, Xavier Graña, Yan Zhou, Norman H. Lee, Rory Thompson, Anelia Horvath, Kerry S. Campbell, Fang Jin, Tim Kwok, Wayne McLaughlin, Sharon Harrison, Denise Gibbs, Shannique Clarke, Mark Young, Warren Chin, Elon Thompson, Jason S. Wasserman, Holly Fowle, Ziran Zhao, Belinda Morrison, William Aiken, Henkel Valentine
STR profile of ACRJ-PC28 generated by IDEXX using PC indicates the novelty of the cell line (A) as the cell line senctic profile was compared to the profiles of other cell lines in the DSMZ STR database and did not match anv other reported profiles h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d561eb219ab2ec0be454301fca18ac88
https://doi.org/10.1158/2767-9764.22545618.v1
https://doi.org/10.1158/2767-9764.22545618.v1
Autor:
Simone Badal, Camille Ragin, Xavier Graña, Yan Zhou, Norman H. Lee, Rory Thompson, Anelia Horvath, Kerry S. Campbell, Fang Jin, Tim Kwok, Wayne McLaughlin, Sharon Harrison, Denise Gibbs, Shannique Clarke, Mark Young, Warren Chin, Elon Thompson, Jason S. Wasserman, Holly Fowle, Ziran Zhao, Belinda Morrison, William Aiken, Henkel Valentine
Tissue sample was obtained from a transrectal needle biopsy of the prostate gland of a patient with PSA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10b27a5ef5cb52eb21aeef38b5efef08
https://doi.org/10.1158/2767-9764.22545615.v1
https://doi.org/10.1158/2767-9764.22545615.v1