Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Holly Clouse"'
Autor:
John P Imredy, Holly Clouse, Armando Lagrutta, Michael P Graziano, Krista M Durney, Wilson Hsieh, Jamie Gearhart, Brian Schriver, Nathan W Bay, Nicole T Feric
Publikováno v:
Circulation Research. 131
MK-8722, a systemic pan-AMPK activator improves glucose homeostasis in animal models of diabetes, but causes cardiac hypertrophy # . Two- and 3-dimensional tissue (2D,3D) constructs of human induced pluripotent stem cell derived cardiomyocytes (CM) (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c49089682703f9d66163317efcdbb52c
https://doi.org/10.1161/res.131.suppl_1.p2031
https://doi.org/10.1161/res.131.suppl_1.p2031
Publikováno v:
Applied In Vitro Toxicology. 6:144-155
We reported that blockade of Ca2+ channel increased beating rate on human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) when in hiPSC-CM culture media, but decreased beating rate...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee05d9e78e62efdbbaef2ab6bae209b9
https://doi.org/10.1089/aivt.2020.0013
https://doi.org/10.1089/aivt.2020.0013
Publikováno v:
Toxicological Sciences. 167:573-580
Calcium channel blockers (CCBs), such as diltiazem, nifedipine, and verapamil, cause tachycardia effects on several commercially available human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), when tested in culture media provided b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a0496ec1502cec63d4631efbab6d92
https://doi.org/10.1093/toxsci/kfy264
https://doi.org/10.1093/toxsci/kfy264
Publikováno v:
JRSM Cardiovascular Disease, Vol 8 (2019)
Objective We investigated if there is IKs, and if there is repolarization reserve by IKs in human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). Design We used a specific KCNQ1/KCNE1 channel blocker, L-000768673, with an IC50 of 9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bf8a36764dec719c26621a5e6f61278
https://doaj.org/article/2caecd0927db476ba4b6cc8a907543b0
https://doaj.org/article/2caecd0927db476ba4b6cc8a907543b0
Autor:
Jennifer B. Pierson, Armando Lagrutta, Holly Clouse, Michael Furniss, Ivan Kopljar, Frederick Sannajust, Ralf Kettenhofen, Haoyu Zeng, Hua Rong Lu, Karel Van Ammel, Fetene Tekle, Ard Teisman, Jin Zhai, Liang Guo, David J. Gallacher
Publikováno v:
Toxicol Sci
The goal of this research consortium including Janssen, MSD, Ncardia, FNCR/LBR, and Health and Environmental Sciences Institute (HESI) was to evaluate the utility of an additional in vitro assay technology to detect potential drug-induced long QT and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4418e4a66a243ef3d4307d9ae9b7ee7
https://pubmed.ncbi.nlm.nih.gov/31020317
https://pubmed.ncbi.nlm.nih.gov/31020317
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 99:106595
Calcium channel blockers (CCBs), such as diltiazem, nifedipine, and verapamil, cause tachycardia effects on several commercially available human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), when tested in culture media provided b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8eda03fcd850521f00e0fe42096935f
https://doi.org/10.1016/j.vascn.2019.05.158
https://doi.org/10.1016/j.vascn.2019.05.158