Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Holly Burr"'
Autor:
Heather L Gardner, Sarah B Rippy, Misty D Bear, Kim L Cronin, Heather Heeb, Holly Burr, Claire M Cannon, Kumar V Penmetsa, Srikant Viswanadha, Swaroop Vakkalanka, Cheryl A London
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195357 (2018)
RV1001 is a novel, potent, and selective PI3Kδ inhibitor. The purpose of this study was to evaluate the safety and efficacy of RV1001 in canine Non-Hodgkin lymphoma (NHL).Inhibition of endogenous pAKT by RV1001 in primary canine NHL cells was determ
Externí odkaz:
https://doaj.org/article/2cde8c7101d8458aaeb72cfb3d0632c4
Autor:
Joel A. Saydoff, Rolando A.G. Garcia, Susan E. Browne, Liansheng Liu, Jin Sheng, Denise Brenneman, Zhongyi Hu, Sylvain Cardin, Alexis Gonzalez, Reid W. von Borstel, Jason Gregorio, Holly Burr, M. Flint Beal
Publikováno v:
Neurobiology of Disease, Vol 24, Iss 3, Pp 455-465 (2006)
Previously, uridine pro-drug 2′,3′,5′-tri-O-acetyluridine (PN401) was shown to be protective in the mitochondrial complex II inhibitor 3-nitropropionic acid model of Huntington's disease (HD). In this study, PN401 increased survival and improve
Externí odkaz:
https://doaj.org/article/af8ec1366eed4784b770dcc6d779fe9a
Autor:
Smita Salian-Mehta, Wanda West, Holly Burr, Nancy Poy, Kathleen A. Murray, Jolaine M. Wilson, Abigail Wolf Greenstein
Publikováno v:
Toxicology Research and Application, Vol 5 (2021)
Contract Research Organizations (CROs) conducting toxicology studies on behalf of biopharmaceutical sponsors and others routinely provide supportive care for animals to minimize pain and distress on studies. A large number of guidance documents gover
Autor:
William E. Achanzar, Holly Burr, Mark Tirmenstein, Jacqueline Calvano, Bethanne Murphy, Raja Mangipudy, Janet DiPiero, Clifford J. Hixson, Cecilia Parrula
Publikováno v:
Toxicology and Applied Pharmacology. 312:53-60
Conventional circulating biomarkers of cardiac and skeletal muscle (SKM) toxicity lack specificity and/or have a short half-life. MicroRNAs (miRNAs) are currently being assessed as biomarkers of tissue injury based on their long half-life in blood an
Autor:
Jacqueline Calvano, Holly Burr, Mark Tirmenstein, Clifford J. Hixson, Gwendolyn Edwards, Raja Mangipudy
Publikováno v:
Toxicology.
Pancreatic injury in rats is primarily detected through histopathological changes and conventional serum biomarkers such as amylase and lipase. However, amylase and lipase have a short half-life and are markers of acinar, not islet cell injury. We in
Autor:
Sarah B. Rippy, Claire M Cannon, Srikant Viswanadha, Kim L. Cronin, Heather L. Gardner, Cheryl A. London, Swaroop Vakkalanka, Kumar V. Penmetsa, Holly Burr, Heather Heeb, Misty D. Bear
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195357 (2018)
PLoS ONE
PLoS ONE
Background RV1001 is a novel, potent, and selective PI3Kδ inhibitor. The purpose of this study was to evaluate the safety and efficacy of RV1001 in canine Non-Hodgkin lymphoma (NHL). Methods and results Inhibition of endogenous pAKT by RV1001 in pri
Autor:
Vinyas Harish, Emmalin Buajitti, Holly Burrows, Joshua Posen, Isaac I Bogoch, Antoine Corbeil, Jonathan B Gubbay, Laura C Rosella, Shaun K Morris
Publikováno v:
PLOS Global Public Health, Vol 3, Iss 3, p e0001608 (2023)
As the frequency of international travel increases, more individuals are at risk of travel-acquired infections (TAIs). In this ecological study of over 170,000 unique tests from Public Health Ontario's laboratory, we reviewed all laboratory-reported
Externí odkaz:
https://doaj.org/article/782b232c52d445d7a74182343ec3e826
Publikováno v:
Comparative medicine. 65(3)
A 4-y-old female cynomolgus macaque presented for veterinary evaluation prior to placement in a preclinical study showed markedly low platelet counts that continued to decrease over time. Physical examination over the next several days showed areas o
Autor:
Nelly Aranibar, Ronald C. West, Jagannatha Mysore, Shawn P. Clark, Raja Mangipudy, John C. Kozlosky, Ragini Vuppugalla, Jinze Li, Holly Burr, Michael J. Graziano
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 73(1)
This comparative study was conducted to assess background physiologic and pharmacologic parameters of cynomolgus macaques (Macaca fascicularis) from Cambodia, from a mixed Asian source (Cambodia, Vietnam and Indonesia), and from Mauritius. This evalu
Autor:
Holly Burr, Sylvain Cardin, Liansheng Liu, Reid W. von Borstel, Zhongyi Hu, Susan E. Browne, Denise Brenneman, Jason Gregorio, Jin Sheng, Rolando Garcia, M. Flint Beal, Joel A. Saydoff, Alexis Gonzalez
Publikováno v:
Neurobiology of Disease, Vol 24, Iss 3, Pp 455-465 (2006)
Previously, uridine pro-drug 2',3',5'-tri-O-acetyluridine (PN401) was shown to be protective in the mitochondrial complex II inhibitor 3-nitropropionic acid model of Huntington's disease (HD). In this study, PN401 increased survival and improved moto