Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Holly Bachus"'
Autor:
Holly Bachus, Erin McLaughlin, Crystal Lewis, Amber M. Papillion, Etty N. Benveniste, Dave Durell Hill, Alexander F. Rosenberg, André Ballesteros-Tato, Beatriz León
Defective interleukin-6 (IL-6) signaling has been associated with Th2 bias and elevated IgE levels. However, the underlying mechanism by which IL-6 prevents the development of Th2-driven diseases remains unknown. Using a model of house dust mite (HDM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d5e7dd6f4c3d0cf3a16a7f7f2dd4d70
https://doi.org/10.1101/2022.12.05.519197
https://doi.org/10.1101/2022.12.05.519197
Autor:
Alexander F. Rosenberg, Beatriz León, André Ballesteros-Tato, Meagan M. Jenkins, Holly Bachus, Davide Botta, Michael D. Schultz
Publikováno v:
Science Immunology. 6
CD8+ T cell responses to pulmonary challenges are primed by lung migratory dendritic cells (mDCs), which capture antigens in the lungs and migrate to the lung-draining mediastinal lymph node (med-L...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74b5ff4f35a3b31e068a9fa1da6e7912
https://doi.org/10.1126/sciimmunol.abg6895
https://doi.org/10.1126/sciimmunol.abg6895
Autor:
Meagan M, Jenkins, Holly, Bachus, Davide, Botta, Michael D, Schultz, Alexander F, Rosenberg, Beatriz, León, André, Ballesteros-Tato
Publikováno v:
Sci Immunol
CD8(+) T cell responses to pulmonary challenges are primed by lung migratory dendritic cells (mDCs), which capture antigens in the lungs and migrate to the lung-draining mediastinal lymph node (med-LN) to activate T cells. Notably, the lungs and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5381d8228790f4c6c0e39fd4449c1878
https://pubmed.ncbi.nlm.nih.gov/34516781
https://pubmed.ncbi.nlm.nih.gov/34516781
Autor:
André Ballesteros-Tato, Holly Bachus, Kamaljeet Kaur, Alexander F. Rosenberg, Amber M. Papillion, Beatriz León
Publikováno v:
SSRN Electronic Journal.
Lipopolysaccharide (LPS) can either promote or prevent T helper-2 (Th2) cell-allergic responses. However, the underlying mechanism remains unknown. We show here that monocytes play an essential role in mediating LPS-induced protection from allergic i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc883210bbbbbf9b3836514356e41e76
https://doi.org/10.2139/ssrn.3753799
https://doi.org/10.2139/ssrn.3753799
Autor:
Kamaljeet Kaur, Holly Bachus, Crystal Lewis, Amber M. Papillion, Alexander F. Rosenberg, André Ballesteros-Tato, Beatriz León
Publikováno v:
Cell reports
SUMMARY Lipopolysaccharide (LPS) can either promote or prevent T helper 2 (Th2) cell allergic responses. However, the underlying mechanism remains unknown. We show here that LPS activity switches from pro-pathogenic to protective depending on the pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df29516ed216cb314b93141f6ca000d7
https://doi.org/10.1016/j.celrep.2021.110178
https://doi.org/10.1016/j.celrep.2021.110178
Autor:
Beatriz León, Michael J. Fuller, Amber M. Papillion, Alejandro V. Villarino, Amy S. Weinmann, John J. O'Shea, Danielle A. Chisolm, André Ballesteros-Tato, Michael D. Powell, Kenneth J. Oestreich, Holly Bachus
Publikováno v:
Science immunology. 4(39)
Sustained TCR stimulation is required for maintaining germinal center T follicular helper cells (GC-T(FH)). Paradoxically, TCR activation induces interleukin-2 receptor (IL-2R) expression and IL-2 production, thereby initiating a feedback loop of IL-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec39fb7367af2b795d2e4e130996cb28
https://pubmed.ncbi.nlm.nih.gov/31519813
https://pubmed.ncbi.nlm.nih.gov/31519813
Autor:
Holly Bachus, Tatiana T. Marquez-Lago, Beatriz León, Sadis Matalon, Zhihong Yu, Amber M. Papillion, André Ballesteros-Tato, Kamaljeet Kaur
Infants have a higher risk of developing allergic asthma than adults. However, the underlying mechanism remains unknown. We show here that sensitization of mice with house-dust mites (HDMs) in the presence of low-dose lipopolysaccharide (LPS) prevent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc04c53a22254c7a68999a31d9fffc8
https://europepmc.org/articles/PMC6335154/
https://europepmc.org/articles/PMC6335154/
Publikováno v:
The Journal of Immunology. 206:66.04-66.04
T follicular helper (TFH) cells promote antibody (Ab) responses by providing both survival and differentiation signals to B cells. As such, the expansion of self-reactive TFH cells contributes to auto-Ab production and correlates with disease severit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d953074101f8fb611c4531330bdb489
https://doi.org/10.4049/jimmunol.206.supp.66.04
https://doi.org/10.4049/jimmunol.206.supp.66.04
Autor:
Meagan M Jenkins, Holly Bachus, Davide Botta, Michael Schultz, Alexander Rosenberg, Beatriz León, André Ballesteros-Tato
Publikováno v:
The Journal of Immunology. 206:103.06-103.06
CD8+ T cell responses to influenza virus infection are canonically known to be activated solely in the lung draining, mediastinal lymph node (mLN). Mechanistically, migratory dendritic cells (mDCs) are activated in the lungs and traffic to the mLN wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f980cf4cdc01b0185e5d74d00e5f25f
https://doi.org/10.4049/jimmunol.206.supp.103.06
https://doi.org/10.4049/jimmunol.206.supp.103.06
Publikováno v:
The Journal of Immunology. 204:94.7-94.7
Initiation of CD8+ T cell responses to influenza virus requires the trafficking of activated lung-migratory dendritic cells (mDCs) from the lung into the lung-draining mediastinal LN (mLN) in response to influenza virus infection in the lungs. As suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ef6426d30a8edc38905b84282fc7d54
https://doi.org/10.4049/jimmunol.204.supp.94.7
https://doi.org/10.4049/jimmunol.204.supp.94.7