The genomic epidemiology of Neisseria meningitidis carriage from a randomised controlled trial of 4CMenB vaccination in an asymptomatic adolescent populationResearch in context

Autor: Lex E.X. Leong, Rosa C. Coldbeck-Shackley, Mark McMillan, Holly B. Bratcher, Mark Turra, Andrew Lawrence, Charlene Kahler, Martin C.J. Maiden, Geraint B. Rogers, Helen Marshall

Publikováno v: The Lancet Regional Health. Western Pacific, Vol 43, Iss , Pp 100966- (2024)

Summary: Background: Oropharyngeal carriage of Neisseria meningitidis is frequent during adolescence, representing a major source of invasive meningococcal disease. This study examined the impact of a serogroup B vaccination (Bexsero, GSK 4CMenB) pro

Externí odkaz: https://doaj.org/article/7f029232e4ee4d36a0ae09c1daeccdf9

Genome-wide association studies reveal the role of polymorphisms affecting factor H binding protein expression in host invasion by Neisseria meningitidis.

Autor: Sarah G Earle, Mariya Lobanovska, Hayley Lavender, Changyan Tang, Rachel M Exley, Elisa Ramos-Sevillano, Douglas F Browning, Vasiliki Kostiou, Odile B Harrison, Holly B Bratcher, Gabriele Varani, Christoph M Tang, Daniel J Wilson, Martin C J Maiden

Publikováno v: PLoS Pathogens, Vol 17, Iss 10, p e1009992 (2021)

Many invasive bacterial diseases are caused by organisms that are ordinarily harmless components of the human microbiome. Effective interventions against these microbes require an understanding of the processes whereby symbiotic or commensal relation

Externí odkaz: https://doaj.org/article/0b6f3dfc4de74b43a1339c59c7591f44

UKMenCar4: A cross-sectional survey of asymptomatic meningococcal carriage amongst UK adolescents at a period of low invasive meningococcal disease incidence [version 1; peer review: 2 approved]

Autor: Holly B. Bratcher, Charlene M. C. Rodrigues, Adam Finn, Mandy Wootton, J. Claire Cameron, Andrew Smith, Paul Heath, Shamez Ladhani, Matthew D. Snape, Andrew J. Pollard, Richard Cunningham, Raymond Borrow, Caroline Trotter, Stephen J. Gray, Martin C. J. Maiden, Jenny M. MacLennan

Publikováno v: Wellcome Open Research, Vol 4 (2019)

Carriage of Neisseria meningitidis, the meningococcus, is a prerequisite for invasive meningococcal disease (IMD), a potentially devastating infection that disproportionately afflicts infants and children. Humans are the sole known reservoir for the

Externí odkaz: https://doaj.org/article/aac1612fd0564f2a9e1f1b4f410d05e8

Effect of 4cmenb Vaccination on the Genomic Epidemiology of Neisseria Meningitidis Oropharyngeal Carriage in an Asymptomatic Adolescent Population

Autor: Lex EX Leong, Rosa C. Coldbeck-Shackley, Mark McMillan, Holly B. Bratcher, Mark Turra, Andrew J. Lawrence, Charlene Kahler, Martin CJ Maiden, Geraint B. Rogers, Helen S. Marshall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc68ad33f9b7a349059f6d3d8c60b992
https://doi.org/10.2139/ssrn.4415661

Impact of meningococcal ACWY conjugate vaccines on pharyngeal carriage in adolescents: evidence for herd protection from the UK MenACWY programme

Autor: Jeremy P. Carr, Jenny M. MacLennan, Emma Plested, Holly B. Bratcher, Odile B. Harrison, Parvinder K. Aley, James E. Bray, Susana Camara, Charlene M.C. Rodrigues, Kimberly Davis, Angela Bartolf, David Baxter, J. Claire Cameron, Richard Cunningham, Saul N. Faust, Katy Fidler, Rohit Gowda, Paul T. Heath, Stephen Hughes, Sujata Khajuria, David Orr, Mala Raman, Andrew Smith, David P.J. Turner, Elizabeth Whittaker, Christopher J. Williams, Christos S. Zipitis, Andrew J. Pollard, Jennifer Oliver, Begonia Morales-Aza, Aiswarya Lekshmi, Stephen A. Clark, Ray Borrow, Hannah Christensen, Caroline Trotter, Adam Finn, Martin C. Maiden, Matthew D. Snape, Keith A. Jolley, Karen Ford, Hannah Roberts, Karen Palmer, Debbie Suggitt, Nicola Pemberton, Samantha Ray, Mandy Wootton, Shamez N. Ladhani, Daniel Owens, Katrina Cathie, Simon Royal, Neil Oldfield, Roisin Ure, Jennifer Richards, Rebecca Ramsay, Samantha Thomson Hill, Kaltun Duale

Publikováno v: Carr, J P, MacLennan, J M, Plested, E, Bratcher, H B, Harrison, O B, Aley, P K, Oliver, J, Morales-Aza, B, Christensen, H & Maiden, M C & et, A 2022, ' Impact of meningococcal ACWY conjugate vaccines on pharyngeal carriage in adolescents : evidence for herd protection from the UK MenACWY programme ', Clinical Microbiology and Infection, vol. 28, no. 12, pp. 1649.e1-1649.e8 . https://doi.org/10.1016/j.cmi.2022.07.004

Objective:Serogroup W and Y invasive meningococcal disease increased globally from 2000 onwards. Responding to a rapid increase in serogroup W clonal complex 11 (W:cc11) invasive meningococcal disease, the UK replaced an adolescent booster dose of me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bce77ca6a0e717154645cbc98f89339
https://researchonline.lshtm.ac.uk/id/eprint/4667094/1/Carr_etal_2022_Impact-of-meningococcal-acwy-conjugate.pdf