Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Holly A. Reeve"'
Autor:
Daria Sokolova, Tara C. Lurshay, Jack S. Rowbotham, Georgia Stonadge, Holly A. Reeve, Sarah E. Cleary, Tim Sudmeier, Kylie A. Vincent
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract Cleaner synthesis of amines remains a key challenge in organic chemistry because of their prevalence in pharmaceuticals, agrochemicals and synthetic building blocks. Here, we report a different paradigm for chemoselective hydrogenation of ni
Externí odkaz:
https://doaj.org/article/8edcc78d71dd4cfc9cd2538d818cff90
Autor:
Sarah E. Cleary, Sofia Kazantzi, Joshua A. Trenchard, Martin Monedero, Jack W. Allman, Tara C. Lurshay, Xu Zhao, Michael B. C. Kenny, Holly A. Reeve
Publikováno v:
Frontiers in Catalysis, Vol 3 (2023)
Introduction: This work was carried out to understand if a heterogeneous biocatalytic hydrogenation system could be implemented in a slurry mode continuous flow reactor, as a “slot-in” alternative to a metal/carbon catalyst with minimal process o
Externí odkaz:
https://doaj.org/article/90770aebfeba40f59bb5f9e04e0c55a4
Autor:
Miguel A. Ramirez, Shiny Joseph Srinivasan, Sarah E. Cleary, Peter M. T. Todd, Holly A. Reeve, Kylie A. Vincent
Publikováno v:
Frontiers in Catalysis, Vol 2 (2022)
Hydrogenase-mediated reduction of flavin mononucleotide by H2 is exploited to enable cleaner application of nitroreductase enzymes for reduction of aromatic nitro functional groups. This turns the overall reaction into a biocatalytic hydrogenation. U
Externí odkaz:
https://doaj.org/article/db6d00e74b944c4ea118b2308a13893a
Publikováno v:
Frontiers in Chemical Engineering, Vol 3 (2021)
Translation of redox biocatalysis into a commercial hydrogenation flow reactor, with in-built electrolytic H2 generation, was achieved using immobilized enzyme systems. Carbon-supported biocatalysts were first tested in batch mode, and were then tran
Externí odkaz:
https://doaj.org/article/8d75439194f1431c857625154a81d777
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 64:181-186
This practitioner protocol describes the synthesis of a family of deuterated nicotinamide cofactors: [4S-2 H]NADH, [4R-2 H]NADH, [4-2 H2 ]NADH and [4-2 H]NAD+ . The application of a recently developed H2 -driven heterogeneous biocatalyst enables the
Autor:
Jack S. Rowbotham, Holly A. Reeve, Miguel A. Ramirez, Ceren Zor, Jake H. Nicholson, Nicole Grobert, Lisa A. Thompson, Kylie A. Vincent
Publikováno v:
ChemCatChem. 12:3913-3918
The high selectivity of biocatalysis offers a valuable method for greener, more efficient production of enantiopure molecules. Operating immobilised enzymes in flow reactors can improve the productivity and handling of biocatalysts, and using H2 gas
Autor:
Holly A. Reeve, Jake Nicholson, Farieha Altaf, Thomas H. Lonsdale, Janina Preissler, Lars Lauterbach, Oliver Lenz, Silke Leimkühler, Frank Hollmann, Caroline E. Paul, Kylie A. Vincent
Publikováno v:
Chemical Communications, 58(75)
Chemical communications: ChemComm 58, 10540-10543 (2022). doi:10.1039/D2CC02411J
Chemical communications: ChemComm 58, 10540-10543 (2022). doi:10.1039/D2CC02411J
Chemical communications: ChemComm 58, 10540-10543 (2022). doi:10.1039/D2CC02411J
Published by The Royal Society of Chemistry, Cambridge
Published by The Royal Society of Chemistry, Cambridge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03f2d45a61b6eef2a44277eb88765c4a
Publikováno v:
Frontiers in Chemical Engineering, Vol 3 (2021)
Translation of redox biocatalysis into a commercial hydrogenation flow reactor, with in-built electrolytic H2 generation, was achieved using immobilized enzyme systems. Carbon-supported biocatalysts were first tested in batch mode, and were then tran
Autor:
Holly A. Reeve, Kylie A. Vincent, Katrina S. Madden, Peter M.T. Todd, Kouji Urata, Angela J. Russell
Barriers to the ready adoption of biocatalysis into asymmetric synthesis for early stage medicinal chemistry are addressed, using ketone reduction by alcohol dehydrogenase as a model reaction. An efficient substrate screening approach is used to show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ae6d9df81387a16c095aacf8d5e9b49
https://doi.org/10.26434/chemrxiv.13134767.v1
https://doi.org/10.26434/chemrxiv.13134767.v1
Hybrid Chemo-, Bio-, and Electrocatalysis for Atom-Efficient Deuteration of Cofactors in Heavy Water
Publikováno v:
ACS Catalysis
Rowbotham, J, Reeve, H & Vincent, K 2021, ' Hybrid Chemo-, Bio-, and Electrocatalysis for Atom-Efficient Deuteration of Cofactors in Heavy Water ', ACS Catalysis, vol. 11, no. 5, pp. 2596-2604 . https://doi.org/10.1021/acscatal.0c03437
Rowbotham, J, Reeve, H & Vincent, K 2021, ' Hybrid Chemo-, Bio-, and Electrocatalysis for Atom-Efficient Deuteration of Cofactors in Heavy Water ', ACS Catalysis, vol. 11, no. 5, pp. 2596-2604 . https://doi.org/10.1021/acscatal.0c03437
Deuterium-labeled nicotinamide cofactors such as [4-2H]-NADH can be used as mechanistic probes in biological redox processes and offer a route to the synthesis of selectively [2H] labeled chemicals via biocatalytic reductive deuteration. Atom-efficie