Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Holly A. Modafferi"'
Autor:
Ravi V.J. Chari, John M. Lambert, Victor Goldmacher, Jan Pinkas, Rajeeva Singh, Holly A. Modafferi, Alan Wilhelm, Michele F. Mayo, Charlene A. Audette, Erin K. Maloney, Katie E. Archer, Emily E. Reid, Yelena Kovtun, Kathleen R. Whiteman, Wei Li, Nathan E. Fishkin, Michael L. Miller
Comparative in vitro potency of IGNs with a diimine (1), monoimine (3), and diamine (2) towards hematologic and solid tumor cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060b3dbf22b8e72bcb6de9a2cf408c75
https://doi.org/10.1158/1535-7163.22508386
https://doi.org/10.1158/1535-7163.22508386
Autor:
Ravi V.J. Chari, John M. Lambert, Victor Goldmacher, Jan Pinkas, Rajeeva Singh, Holly A. Modafferi, Alan Wilhelm, Michele F. Mayo, Charlene A. Audette, Erin K. Maloney, Katie E. Archer, Emily E. Reid, Yelena Kovtun, Kathleen R. Whiteman, Wei Li, Nathan E. Fishkin, Michael L. Miller
Synthesis of IGNs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c4d0a62fe9e14ab872c4a228aa07177
https://doi.org/10.1158/1535-7163.22508392.v1
https://doi.org/10.1158/1535-7163.22508392.v1
Autor:
Ravi V.J. Chari, John M. Lambert, Victor Goldmacher, Jan Pinkas, Rajeeva Singh, Holly A. Modafferi, Alan Wilhelm, Michele F. Mayo, Charlene A. Audette, Erin K. Maloney, Katie E. Archer, Emily E. Reid, Yelena Kovtun, Kathleen R. Whiteman, Wei Li, Nathan E. Fishkin, Michael L. Miller
Effect of substitution of an indolino moiety (6) for a pyrrolo group (SJG-136) on in vitro potency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25e6f420025bb17b664c20a4f38000ea
https://doi.org/10.1158/1535-7163.22508389.v1
https://doi.org/10.1158/1535-7163.22508389.v1
Autor:
Ravi V.J. Chari, John M. Lambert, Victor Goldmacher, Jan Pinkas, Rajeeva Singh, Holly A. Modafferi, Alan Wilhelm, Michele F. Mayo, Charlene A. Audette, Erin K. Maloney, Katie E. Archer, Emily E. Reid, Yelena Kovtun, Kathleen R. Whiteman, Wei Li, Nathan E. Fishkin, Michael L. Miller
Figure S1. Comparison of the rate of adduct formation of the indolinobenzodiazepine dimer 6 and the pyrrolobenzodiazepine dimer SJG-136 with dsDNA prepared from annealing of single strand DNA 3'-TATAGATCTATA-5'. Figure S2. A, In vitro potency of anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b8679b5302ba5296c6d41da8fcd17ee
https://doi.org/10.1158/1535-7163.22508395
https://doi.org/10.1158/1535-7163.22508395
Autor:
Ravi V.J. Chari, John M. Lambert, Victor Goldmacher, Jan Pinkas, Rajeeva Singh, Holly A. Modafferi, Alan Wilhelm, Michele F. Mayo, Charlene A. Audette, Erin K. Maloney, Katie E. Archer, Emily E. Reid, Yelena Kovtun, Kathleen R. Whiteman, Wei Li, Nathan E. Fishkin, Michael L. Miller
Extent of DNA adduct formation in EOL-1 (AML cells) exposed to the IGN diimine 7 or the monoimine 8 after a 5 h or 20 h exposure to the compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66be45c4892d11630fc17e01803bd78d
https://doi.org/10.1158/1535-7163.22508383
https://doi.org/10.1158/1535-7163.22508383
Autor:
Yelena Kovtun, Ravi V. J. Chari, Rajeeva Singh, John M. Lambert, Emily E. Reid, Holly A. Modafferi, Michael L. Miller, Michele Mayo, Nathan Fishkin, Katie E. Archer, Charlene Audette, Alan Wilhelm, Jan Pinkas, Wei Li, Kathleen R. Whiteman, Victor S. Goldmacher, Erin K. Maloney
Publikováno v:
Molecular cancer therapeutics. 15(8)
The promise of tumor-selective delivery of cytotoxic agents in the form of antibody–drug conjugates (ADC) has now been realized, evidenced by the approval of two ADCs, both of which incorporate highly cytotoxic tubulin-interacting agents, for cance
Autor:
Katharine C. Lai, Lintao Wang, Ravi V. J. Chari, Holly Johnson-Modafferi, Surina Sikka, Kathleen R. Whiteman, Charlene Audette, Xiuxia Sun, Megan Bogalhas, Prerak Shah, Alan Wilhelm, Rassol Laleau, Thomas A. Keating
Publikováno v:
Cancer Research. 75:4504-4504
IMGN779, an antibody-drug conjugate (ADC) consisting of the anti-CD33 antibody, Z4681A, linked to the potent DNA-alkylating agent, DGN462, via a charged disulfide linker, sulfo-SPDB, is in development for the treatment of acute myeloid leukemia (AML)