Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Holly A. Magna"'
Autor:
Eugenius S. B. C. Ang, Holly A. Magna, Eric Schaeffer, Panos Zagouras, Janice Holland, Eric J. Nestler, Jingshan Chen
Publikováno v:
Journal of Neurochemistry. 79:221-224
DeltaFosB is a Fos family transcription factor that is induced by chronic exposure to cocaine and other drugs of abuse in the nucleus accumbens and related striatal regions, brain regions that are important for the behavioral effects of these drugs.
Autor:
Deborah Finco-Kent, Panayiotis Zagouras, James F. Smith, Kwansik Yoon, Douglas A. Fisher, Randall E. Morris, Jeffrey M. Casavant, Eileen A. Elliott, Dominic C. Borie, William H. Martin, Craig R. Kent, Paul S. Changelian, Linda F. Nelms, John J. O'Shea, Bonnie J. Rizzuti, Anthony J. Milici, Sandra P. McCurdy, Bret D. Perry, Todd Andrew Blumenkopf, Michael John Munchhof, John P. Higgins, Ming-Sing Si, Michael J Larson, William H. Brissette, Chakrapani Subramanyam, Thasia G. Woodworth, Timothy J. Strelevitz, John L. Doty, Bari Holm, Mark Edward Flanagan, Mary Josephine Saltarelli, Gretchen E Beckius, Chunyan Su, Ricardo T. Paniagua, Michael Hines, Chan R. Beals, Johnson Kimberly Sue, Maryrose J. Conklyn, Bruce H. Littman, Kelly S. Magnuson, Holly A. Magna, Perry S. Sawyer, Bruce A. Reitz, Brett M. Lillie, Lisa S. Hayes, Kudlacz Elizabeth M, David A. Whipple, James D. Moyer, Erika R. Koslov, Jianmin Sun, Matthew Frank Brown, Anderson See Gaweco, Yong Jie Zhou, Chang Shang-Poa, Deanna L. Baker, Thomas T. Kawabata, Shelley G. des Etages, Michael B. Fisher, Douglas J. Ball
Publikováno v:
Science. 302:875-878
Because of its requirement for signaling by multiple cytokines, Janus kinase 3 (JAK3) is an excellent target for clinical immunosuppression. We report the development of a specific, orally active inhibitor of JAK3, CP-690,550, that significantly prol
Autor:
Paul S. Changelian, Laurie A. Carroll, Ann M. Laquerre, Michele M. O'Donnell, Ronald P. Gladue, Arthur Ernest Franke, Holly A. Magna
Publikováno v:
Cytokine. 6(3)
A heterodimer containing the mouse 35 kDa and human 40 kDa subunit of IL-12 was expressed in COS cells (cIL-12). Administration of 25-200 U of the cIL-12-COS supernatant to mice twice daily for 2 days augmented spleen cell IFN-gamma production in res