Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Holly A. Leddy"'
Autor:
Amber T. Collins, Guoli Hu, Hunter Newman, Michael H. Reinsvold, Monique R. Goldsmith, John N. Twomey-Kozak, Holly A. Leddy, Deepika Sharma, Leyao Shen, Louis E. DeFrate, Courtney M. Karner
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Osteoarthritis is a debilitating disease characterized by cartilage degradation and altered cartilage mechanical properties. Furthermore, it is well established that obesity is a primary risk factor for osteoarthritis. The purpose of this st
Externí odkaz:
https://doaj.org/article/3a6956c4a3614608acf2c34be56a4605
Autor:
Wolfgang Liedtke, Daniel Palmer, Holly A. Leddy, Chia-Lung Wu, Vincent P. Willard, Farshid Guilak
Publikováno v:
Stem Cells
Transient receptor potential vanilloid 4 (TRPV4) is a polymodal calcium-permeable cation channel that is highly expressed in cartilage and is sensitive to a variety of extracellular stimuli. The expression of this channel has been associated with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a890f56518750a4d03d448951b37857
https://doi.org/10.1002/stem.3440
https://doi.org/10.1002/stem.3440
Autor:
Wolfgang Liedtke, Brenton D. Hoffman, Natasha Case, Holly A. Leddy, Dianne Little, Farshid Guilak, Christopher L. Gilchrist, Katheryn E. Rothenberg, Laurel Kaye
Publikováno v:
Proceedings of the National Academy of Sciences. 116:1992-1997
Microarchitectural cues drive aligned fibrillar collagen deposition in vivo and in biomaterial scaffolds, but the cell-signaling events that underlie this process are not well understood. Utilizing a multicellular patterning model system that allows
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3a35945ac9a755d2ec20d77ad05f379
https://doi.org/10.1073/pnas.1811095116
https://doi.org/10.1073/pnas.1811095116
Autor:
Wolfgang Liedtke, Holly A. Leddy, Robert J. Nims, Qiaojuan Zhang, Alireza Savadipour, Whasil Lee, Yong Chen, Amy L. McNulty, Fang Liu, Farshid Guilak
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 118(13)
Osteoarthritis (OA) is a painful and debilitating condition of synovial joints without any disease-modifying therapies [A. M. Valdes, T. D. Spector, Nat. Rev. Rheumatol. 7, 23-32 (2011)]. We previously identified mechanosensitive PIEZO channels, PIEZ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf1861699eafdd8678d3709b585d430
https://pubmed.ncbi.nlm.nih.gov/34163062
https://pubmed.ncbi.nlm.nih.gov/34163062
Autor:
M. Reinsvold, Guoli Hu, Deepika Sharma, Holly A. Leddy, Louis E. DeFrate, Courtney M. Karner, Monique R. Goldsmith, Leyao Shen, Hunter Newman, John N. Twomey-Kozak, Amber T. Collins
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Osteoarthritis is a debilitating disease characterized by cartilage degradation and altered cartilage mechanical properties. Furthermore, it is well established that obesity is a primary risk factor for osteoarthritis. The purpose of this study was t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60ff250761b53ada10b1bd3b0a67b9fe
https://pubmed.ncbi.nlm.nih.gov/33452305
https://pubmed.ncbi.nlm.nih.gov/33452305
Autor:
Amy L. McNulty, Whasil Lee, Alireza Savadipour, Wolfgang Liedtke, Farshid Guilak, Fang Liu, Robert J. Nims, Holly A. Leddy, Yong Chen
Osteoarthritis (OA) is a painful and debilitating condition of synovial joints without any disease-modifying therapies (1, 2). We previously identified mechanosensitive PIEZO channels, PIEZO1 and PIEZO2, both expressed in articular cartilage, to func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a937a5d8586e046558ca96572e6d7f9b
https://doi.org/10.1101/2020.05.23.112565
https://doi.org/10.1101/2020.05.23.112565
Autor:
Susan E Christensen, Jeffrey M Coles, Nicole A Zelenski, Bridgette D Furman, Holly A Leddy, Stefan Zauscher, Paolo Bonaldo, Farshid Guilak
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33397 (2012)
Mutation or loss of collagen VI has been linked to a variety of musculoskeletal abnormalities, particularly muscular dystrophies, tissue ossification and/or fibrosis, and hip osteoarthritis. However, the role of collagen VI in bone and cartilage stru
Externí odkaz:
https://doaj.org/article/561a9e69dbf7410f8cd64e493e42c3fa
Autor:
Holly A. Leddy, Farshid Guilak, Jinzi Zhang, Wolfgang Liedtke, Nicole A. Zelenski, Johannah Sanchez-Adams, Paolo Bonaldo
Publikováno v:
Arthritis & Rheumatology. 67:1286-1294
Objective Mechanical factors play a critical role in the physiology and pathology of articular cartilage, although the mechanisms of mechanical signal transduction are not fully understood. We undertook this study to test the hypothesis that type VI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::581787155f6d8fc5240a4d85c3263ea0
https://doi.org/10.1002/art.39034
https://doi.org/10.1002/art.39034
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 388:437-450
Biomechanical factors play a critical role in regulating the physiology as well as the pathology of multiple joint tissues and have been implicated in the pathogenesis of osteoarthritis. Therefore, the mechanisms by which cells sense and respond to m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad31d3abbb55de2768fc83d088c09f2
https://doi.org/10.1007/s00210-014-1078-x
https://doi.org/10.1007/s00210-014-1078-x
Publikováno v:
Proceedings of the National Academy of Sciences. 111:1316-1321
Mechanical loading of joints plays a critical role in maintaining the health and function of articular cartilage. The mechanism(s) of chondrocyte mechanotransduction are not fully understood, but could provide important insights into new physical or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::040af070379b31a63f5d34a7fe8d277c
https://doi.org/10.1073/pnas.1319569111
https://doi.org/10.1073/pnas.1319569111