Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Holly A. Lacko"'
Autor:
Michael D. Dennis, Dandan Xu, Lydia Kutzler, Holly A. Lacko, Weiwei Dai, Scot R. Kimball, Leonard S. Jefferson
Publikováno v:
J Nutr
Background The protein kinase target of rapamycin (mTOR) in complex 1 (mTORC1) is activated by amino acids and in turn upregulates anabolic processes. Under nutrient-deficient conditions, e.g., amino acid insufficiency, mTORC1 activity is suppressed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d42a3fd4c31c8aa90eaa687004184be0
https://pubmed.ncbi.nlm.nih.gov/31875479
https://pubmed.ncbi.nlm.nih.gov/31875479
Autor:
Lydia Kutzler, Kevin L. Shimkus, Scot R. Kimball, Dandan Xu, Holly A. Lacko, Leonard S. Jefferson
Publikováno v:
The FASEB Journal. 33
Previous studies established that leucine stimulates protein synthesis in skeletal muscle to the same extent as a complete mixture of amino acids, and the effect occurs through activation of the me...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d78b9389a6540bd692a3d2390f4596d
https://doi.org/10.1096/fasebj.2019.33.1_supplement.lb594
https://doi.org/10.1096/fasebj.2019.33.1_supplement.lb594
Autor:
Kevin L. Shimkus, Holly A. Lacko, Dandan Xu, Lydia Kutzler, Leonard S. Jefferson, Scot R. Kimball
Publikováno v:
Am J Physiol Endocrinol Metab
Previous studies established that leucine stimulates protein synthesis in skeletal muscle to the same extent as a complete mixture of amino acids, and the effect occurs through activation of the mechanistic target of rapamycin in complex 1 (mTORC1).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bd5bb71350bcc7c00bb37666bb0c6fd
https://pubmed.ncbi.nlm.nih.gov/30835510
https://pubmed.ncbi.nlm.nih.gov/30835510
Autor:
Mary T. Doan, Katherine M. Aird, Michael Zaleski, Raghavendra Gowda, Holly A. Lacko, Meenhard Herlyn, Gao Zhang, Raquel Buj, Natella Maglakelidze, Yiling Lu, Ross Kuskovsky, Maithili Navaratnarajah, Nathaniel W. Snyder, Gavin P. Robertson, Helen Jiang, Chi-Wei Chen, David J. DeGraff, Kelly E. Leon, Lydia Kutzler, Yuka Imamura, Erika S. Dahl, Joshua I. Warrick, Gordon B. Mills, Scot R. Kimball
Publikováno v:
Cell Reports, Vol 28, Iss 8, Pp 1971-1980.e8 (2019)
SummaryReprogrammed metabolism and cell cycle dysregulation are two cancer hallmarks. p16 is a cell cycle inhibitor and tumor suppressor that is upregulated during oncogene-induced senescence (OIS). Loss of p16 allows for uninhibited cell cycle progr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8af20d65c0ad183513ba0ac21114c19
https://pubmed.ncbi.nlm.nih.gov/31699584
https://pubmed.ncbi.nlm.nih.gov/31699584
Publikováno v:
Journal of Virology. 71:1888-1896
The simian virus 40 large T antigen is sufficient to confer on cells multiple transformed cell growth characteristics, including growth to a high cell density, rapid growth in medium containing low serum concentrations, and anchorage-independent grow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83a3e1774cb2727b71b235aa643871b9
https://doi.org/10.1128/jvi.71.3.1888-1896.1997
https://doi.org/10.1128/jvi.71.3.1888-1896.1997
Publikováno v:
Journal of virology. 69(2)
The simian virus 40 large T antigen immortalizes growing primary cells in culture. In addition, this viral oncoprotein cooperates with an activated ras protein to produce dense foci on monolayers of rat embryo fibroblasts (REF). The relationship betw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4979ef5286c6a832f882f12b29fc9dab
https://pubmed.ncbi.nlm.nih.gov/7815561
https://pubmed.ncbi.nlm.nih.gov/7815561