Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Holly A Wichman"'
Autor:
Celeste J Brown, Caleb J Quates, Christopher A Mirabzadeh, Craig R Miller, Holly A Wichman, Tanya A Miura, F Marty Ytreberg
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160410 (2016)
Since the recent devastating outbreak of Ebola virus disease in western Africa, there has been significant effort to understand the evolution of the deadly virus that caused the outbreak. There has been a considerable investment in sequencing Ebola v
Externí odkaz:
https://doaj.org/article/08d6494f738f43d69c55ed83d015af26
Publikováno v:
PLoS Genetics, Vol 10, Iss 9, p e1004531 (2014)
Mammalian genomes comprise many active and fossilized retroelements. The obligate requirement for retroelement integration affords host genomes an opportunity to 'domesticate' retroelement genes for their own purpose, leading to important innovations
Externí odkaz:
https://doaj.org/article/4afacfdc604f4ebc93bb57a368d2735d
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112988 (2014)
Previous studies have shown that most random amino acid substitutions destabilize protein folding (i.e. increase the folding free energy). No analogous studies have been carried out for protein-protein binding. Here we use a structure-based model of
Externí odkaz:
https://doaj.org/article/f17b97d8a9ee4449bc1dd1edb22fe544
Autor:
Dilara Ally, Valorie R Wiss, Gail E Deckert, Danielle Green, Pavitra Roychoudhury, Holly A Wichman, Celeste J Brown, Stephen M Krone
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88702 (2014)
Most clinical and natural microbial communities live and evolve in spatially structured environments. When changes in environmental conditions trigger evolutionary responses, spatial structure can impact the types of adaptive response and the extent
Externí odkaz:
https://doaj.org/article/b6d76007a8f0415aae72c8bd41f5b9a9
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e60401 (2013)
Observing organisms that evolve in response to strong selection over very short time scales allows the determination of the molecular mechanisms underlying adaptation. Although dissecting these molecular mechanisms is expensive and time-consuming, ge
Externí odkaz:
https://doaj.org/article/0053309634ab4e6d92f621aa3730afd8
Publikováno v:
PLoS Genetics, Vol 7, Iss 6, p e1002075 (2011)
Epistatic interactions between genes and individual mutations are major determinants of the evolutionary properties of genetic systems and have therefore been well documented, but few quantitative data exist on epistatic interactions between benefici
Externí odkaz:
https://doaj.org/article/c7c4edfa297b44fd9cb13c556f9e7e77
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e25640 (2011)
The relationship between mutation, protein stability and protein function plays a central role in molecular evolution. Mutations tend to be destabilizing, including those that would confer novel functions such as host-switching or antibiotic resistan
Externí odkaz:
https://doaj.org/article/badb380294ff407385dade00244358a1
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6252 (2009)
Dosage compensation in eutherian mammals occurs by inactivation of one X chromosome in females. Silencing of that X chromosome is initiated by Xist, a large non-coding RNA, whose coating of the chromosome extends in cis from the X inactivation center
Externí odkaz:
https://doaj.org/article/49c17332ec04465abf3e40eafa66d70f
Publikováno v:
Cells, Vol 13, Iss 7, p 585 (2024)
Recombination among different phages sometimes facilitates their ability to grow on new hosts. Protocols to direct the evolution of phage host range, as might be used in the application of phage therapy, would then benefit from including steps to ena
Externí odkaz:
https://doaj.org/article/a0271e3f8b964e79abf59746515a637a
Publikováno v:
Antibiotics, Vol 11, Iss 12, p 1709 (2022)
Background: The host ranges of individual phages tend to be narrow, yet many applications of phages would benefit from expanded host ranges. Empirical methods have been developed to direct the evolution of phages to attack new strains, but the method
Externí odkaz:
https://doaj.org/article/8bd0abbec73040078adf6e5a3341c137