Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Holly A Hung"'
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e109691 (2014)
As next generation sequencing technologies are becoming more economical, large-scale ChIP-seq studies are enabling the investigation of the roles of transcription factor binding and epigenome on phenotypic variation. Studying such variation requires
Externí odkaz:
https://doaj.org/article/dcecdd29a7a644c7a07dfc1285217171
Publikováno v:
Human Molecular Genetics. 27:2830-2839
Peripheral nerve myelination is adversely affected in the most common form of the hereditary peripheral neuropathy called Charcot-Marie-Tooth Disease. This form, classified as CMT1A, is caused by a 1.4 Mb duplication on chromosome 17, which includes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc2fef445888360d1857648b81d75662
https://doi.org/10.1093/hmg/ddy191
https://doi.org/10.1093/hmg/ddy191
Autor:
Holly A. Hung, Guannan Sun, Camila Lopez-Anido, John Svaren, Matthias Koenning, Ben Emery, Rajini Srinivasan, Sunduz Keles
Publikováno v:
Glia. 63:1897-1914
Myelin is formed by specialized myelinating glia: oligodendrocytes and Schwann cells in the central and peripheral nervous systems, respectively. While there are distinct developmental aspects and regulatory pathways in these two cell types, myelinat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb03f5cb94e719889fb0d79a687fa106
https://doi.org/10.1002/glia.22855
https://doi.org/10.1002/glia.22855
Publikováno v:
Journal of Biological Chemistry. 290:6937-6950
Myelination of the peripheral nervous system is required for axonal function and long term stability. After peripheral nerve injury, Schwann cells transition from axon myelination to a demyelinated state that supports neuronal survival and ultimately
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e23670b41d135f7ce4f9c601d0fa4584
https://doi.org/10.1074/jbc.m114.622878
https://doi.org/10.1074/jbc.m114.622878
The rapid and dynamic transcriptional changes of Schwann cells in response to injury are critical to peripheral nerve repair, yet the epigenomic reprograming that leads to the induction of injury-activated genes has not been characterized. Polycomb R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f2ec77d8319cc1b971d13182c7a41d
https://europepmc.org/articles/PMC5005723/
https://europepmc.org/articles/PMC5005723/
Publikováno v:
The Journal of Neuroscience. 32:1517-1527
Several key transcription factors and coregulators important to peripheral nerve myelination have been identified, but the contributions of specific chromatin remodeling complexes to peripheral nerve myelination have not been analyzed. Chromodomain h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f87546a78eaee2f0906d55c2a15b0611
https://doi.org/10.1523/jneurosci.2895-11.2012
https://doi.org/10.1523/jneurosci.2895-11.2012
Publikováno v:
Molecular and cellular endocrinology. 421
The molecular basis of the organogenesis, homeostasis, and tumorigenesis of the adrenal cortex has been the subject of intense study for many decades. Specifically, characterization of tumor predisposition syndromes with adrenocortical manifestations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::078fff0b403fa8d35123f2ca1e8264af
https://pubmed.ncbi.nlm.nih.gov/26678830
https://pubmed.ncbi.nlm.nih.gov/26678830
Myelination of peripheral nerves by Schwann cells requires coordinate regulation of gene repression as well as gene activation. Several chromatin remodeling pathways critical for peripheral nerve myelination have been identified, but the functions of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e1bc592b5c8f230691ca61cb9547f61
https://europepmc.org/articles/PMC4452560/
https://europepmc.org/articles/PMC4452560/