Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Holly A, Saffran"'
Autor:
Joseph K. Sampson Duncan, Danyang Xu, Maria Licursi, Michael A. Joyce, Holly A. Saffran, Kaiwen Liu, Jin Gohda, D. Lorne Tyrrell, Yasushi Kawaguchi, Kensuke Hirasawa
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Interferon regulatory factors (IRFs) are key elements of antiviral innate responses that regulate the transcription of interferons (IFNs) and IFN-stimulated genes (ISGs). While the sensitivity of human coronaviruses to IFNs has been characterized, an
Externí odkaz:
https://doaj.org/article/85bc25bd97804d21b8ce1febd62737a6
Autor:
George Giorgi Babuadze, Hugues Fausther-Bovendo, Marc-Antoine deLaVega, Brandon Lillie, Maedeh Naghibosadat, Nariman Shahhosseini, Michael A. Joyce, Holly A. Saffran, D. Lorne Tyrrell, Darryl Falzarano, Chandrika Senthilkumaran, Natasha Christie-Holmes, Steven Ahn, Scott D. Gray-Owen, Arinjay Banerjee, Samira Mubareka, Karen Mossman, Chanel Dupont, Jannie Pedersen, Mark-Alexandre Lafrance, Gary P. Kobinger, Robert Kozak
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-11 (2022)
Abstract The SARS-CoV-2 pandemic is an ongoing threat to global health, and wide-scale vaccination is an efficient method to reduce morbidity and mortality. We designed and evaluated two DNA plasmid vaccines, based on the pIDV-II system, expressing t
Externí odkaz:
https://doaj.org/article/82794801787e446aa4f47a9d3ccbe1b5
Autor:
Wayne Vuong, Muhammad Bashir Khan, Conrad Fischer, Elena Arutyunova, Tess Lamer, Justin Shields, Holly A. Saffran, Ryan T. McKay, Marco J. van Belkum, Michael A. Joyce, Howard S. Young, D. Lorne Tyrrell, John C. Vederas, M. Joanne Lemieux
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Coronavirus main protease is essential for viral polyprotein processing and replication. Here Vuong et al. report efficient inhibition of SARS-CoV-2 replication by the dipeptide-based protease inhibitor GC376 and its parent GC373, which were original
Externí odkaz:
https://doaj.org/article/3c902c5ef40f40398c856f91dffa7d74
Autor:
Manisha Pandey, Victoria Ozberk, Sharareh Eskandari, Ahmed O Shalash, Michael A Joyce, Holly A Saffran, Christopher J Day, Ailin Lepletier, Belinda L Spillings, Jamie‐Lee Mills, Ainslie Calcutt, Fan Fan, James T Williams, Danielle I Stanisic, Laetitia Hattingh, John Gerrard, Mariusz Skwarczynski, Johnson Mak, Michael P Jennings, Istvan Toth, D Lorne Tyrrell, Michael F Good
Publikováno v:
Clinical & Translational Immunology, Vol 10, Iss 3, Pp n/a-n/a (2021)
Abstract Objectives A major COVID‐19 vaccine strategy is to induce antibodies that prevent interaction between the Spike protein's receptor‐binding domain (RBD) and angiotensin‐converting enzyme 2 (ACE2). These vaccines will also induce T‐cel
Externí odkaz:
https://doaj.org/article/e84bde1bc9874220bdf3a2aceb319bda
Publikováno v:
PLoS Pathogens, Vol 15, Iss 10, p e1008111 (2019)
The herpes simplex virus virion host shutoff (vhs) RNase destabilizes cellular and viral mRNAs and blunts host innate antiviral responses. Previous work demonstrated that cells infected with vhs mutants display enhanced activation of the host double-
Externí odkaz:
https://doaj.org/article/1895672d531d409cb14f8588e8838ce2
Autor:
Wayne Vuong, Muhammad Bashir Khan, Conrad Fischer, Elena Arutyunova, Tess Lamer, Justin Shields, Holly A. Saffran, Ryan T. McKay, Marco J. van Belkum, Michael A. Joyce, Howard S. Young, D. Lorne Tyrrell, John C. Vederas, M. Joanne Lemieux
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/dac69d533a794d48837c50ee74ddec00
Autor:
Michael A. Joyce, Kanti Pabbaraju, Jingyang Xu, Graham Tipples, Hongquan Zhang, Wei Feng, D. Lorne Tyrrell, Hanyong Peng, Holly A. Saffran, Shawn Babiuk, X. Chris Le, Yanming Liu
Publikováno v:
Analytical Chemistry. 93:12808-12816
CRISPR-Cas systems integrated with nucleic acid amplification techniques improve both analytical specificity and sensitivity. We describe here issues and solutions for the successful integration of reverse transcription (RT), recombinase polymerase a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50be5ea3e636117b3dc5e120eca3d2c5
https://doi.org/10.1021/acs.analchem.1c03456
https://doi.org/10.1021/acs.analchem.1c03456
Autor:
Kanti Pabbaraju, Matthew A. Croxen, Holly A. Saffran, Kevin Crawford, Michael Logan, Gerald LaChance, Darren Hockman, John Lok Man Law, D. Lorne Tyrrell, Abdolamir Landi, Janelle Johnson, Graham Tipples, Raelynn Brassard, Justin Shields, Eve Hobart, Michael Houghton, M. Joanne Lemieux, Michael A. Joyce, Elena Arutyunova
Publikováno v:
Vaccine
SARS-CoV-2 is the etiological agent of COVID19. There are currently several licensed vaccines approved for human use and most of them are targeting the spike protein (or virion) in the virion envelope to induce protective immunity. Recently, variants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e103c5c330664243455b4cc9fc1daec9
https://doi.org/10.1016/j.vaccine.2021.08.081
https://doi.org/10.1016/j.vaccine.2021.08.081
Autor:
Muhammad Bashir Khan, Jimmy Lu, Elena Arutyunova, John C. Vederas, James A. Nieman, Howard S. Young, Mohammad Rahim, Yanhua Du, Wayne Vuong, M. Joanne Lemieux, Marco J. van Belkum, Holly A. Saffran, Conrad Fischer, Bing Bai, Alexandr Belovodskiy, Michael A. Joyce, Fusen Lin, Jia Xu, Hena Mostafa, Justin Shields, Darren Hockman, Tess Lamer, D. Lorne Tyrrell, Appan Srinivas Kandadai, Sardeev K Bajwa, Zhengxian Gu
Publikováno v:
Journal of Medicinal Chemistry. 65:2905-2925
Recurring coronavirus outbreaks, such as the current COVID-19 pandemic, establish a necessity to develop direct-acting antivirals that can be readily administered and are active against a broad spectrum of coronaviruses. Described in this Article are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::134b04d6422ffafa8fa4be69bcd0a43a
https://doi.org/10.1021/acs.jmedchem.1c00616
https://doi.org/10.1021/acs.jmedchem.1c00616
Autor:
Howard S. Young, Muhammad Bashir Khan, Hena Mostafa, Tess Lamer, Alexandr Belovodskiy, Justin Shields, Wayne Vuong, Holly A. Saffran, Michael A. Joyce, Elena Arutyunova, Jimmy Lu, James A. Nieman, D. Lorne Tyrrell, Appan Srinivas Kandadai, Bing Bai, John C. Vederas, M. Joanne Lemieux
Publikováno v:
RSC Med Chem
Tragically, the death toll from the COVID-19 pandemic continues to rise, and with variants being observed around the globe new therapeutics, particularly direct-acting antivirals that are easily administered, are desperately needed. Studies targeting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcc67e136d0b12f76b4688d739f493ae
https://doi.org/10.1039/d1md00247c
https://doi.org/10.1039/d1md00247c