Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Holly, Hammond"'
Autor:
James Logue, Robert M. Johnson, Nita Patel, Bin Zhou, Sonia Maciejewski, Bryant Foreman, Haixia Zhou, Alyse D. Portnoff, Jing-Hui Tian, Asma Rehman, Marisa E. McGrath, Robert E. Haupt, Stuart M. Weston, Lauren Baracco, Holly Hammond, Mimi Guebre-Xabier, Carly Dillen, M. Madhangi, Ann M. Greene, Michael J. Massare, Greg M. Glenn, Gale Smith, Matthew B. Frieman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Current SARS-CoV-2 variants evade immune responses induced by approved vaccines. In this study, the authors find that a recombinant prefusion-stabilized Beta spike protein vaccine confers broad neutralization capacity in mice and non-human primates a
Externí odkaz:
https://doaj.org/article/6b9ab71cb4bd4f84b8cc8463a5dfad83
Autor:
Jeremy Ardanuy, Robert Johnson, Carly Dillen, Louis Taylor, Holly Hammond, Stuart Weston, Matthew Frieman
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), continues to be one of the largest dangers to human health around the world. The need for effective antiviral and anti-
Externí odkaz:
https://doaj.org/article/9c672d58a2f1433fac262e20fe17a2c1
Autor:
Megan M Sperry, Tomiko T Oskotsky, Ivana Marić, Shruti Kaushal, Takako Takeda, Viktor Horvath, Rani K Powers, Melissa Rodas, Brooke Furlong, Mercy Soong, Pranav Prabhala, Girija Goyal, Kenneth E Carlson, Ronald J Wong, Idit Kosti, Brian L Le, James Logue, Holly Hammond, Matthew Frieman, David K Stevenson, Donald E Ingber, Marina Sirota, Richard Novak
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 5, p e1011050 (2023)
Drug repurposing requires distinguishing established drug class targets from novel molecule-specific mechanisms and rapidly derisking their therapeutic potential in a time-critical manner, particularly in a pandemic scenario. In response to the chall
Externí odkaz:
https://doaj.org/article/cfab81f7026e481d8f6ae5a6eade32cd
Autor:
Britton Boras, Rhys M. Jones, Brandon J. Anson, Dan Arenson, Lisa Aschenbrenner, Malina A. Bakowski, Nathan Beutler, Joseph Binder, Emily Chen, Heather Eng, Holly Hammond, Jennifer Hammond, Robert E. Haupt, Robert Hoffman, Eugene P. Kadar, Rob Kania, Emi Kimoto, Melanie G. Kirkpatrick, Lorraine Lanyon, Emma K. Lendy, Jonathan R. Lillis, James Logue, Suman A. Luthra, Chunlong Ma, Stephen W. Mason, Marisa E. McGrath, Stephen Noell, R. Scott Obach, Matthew N. O’ Brien, Rebecca O’Connor, Kevin Ogilvie, Dafydd Owen, Martin Pettersson, Matthew R. Reese, Thomas F. Rogers, Romel Rosales, Michelle I. Rossulek, Jean G. Sathish, Norimitsu Shirai, Claire Steppan, Martyn Ticehurst, Lawrence W. Updyke, Stuart Weston, Yuao Zhu, Kris M. White, Adolfo García-Sastre, Jun Wang, Arnab K. Chatterjee, Andrew D. Mesecar, Matthew B. Frieman, Annaliesa S. Anderson, Charlotte Allerton
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The 3CL protease of SARS-CoV-2 is inhibited by PF-00835231 in vitro. Here, the authors show that the prodrug PF-07304814 has broad spectrum activity, inhibiting SARS-CoV and SARS-CoV-2 in mice and its ADME and safety profile support clinical developm
Externí odkaz:
https://doaj.org/article/7c0ac56767d64fb5af7714d7f3a62322
Autor:
Yun Ji, Qi Zhang, Lin Cheng, Jiwan Ge, Ruoke Wang, Mengqi Fang, Eric M. Mucker, Peng Chen, Ji Ma, Rui Zhang, Chunming Li, Holly Hammond, Lauren Baracco, Michael Holbrook, Matthew Frieman, Zheng Zhang, Xinquan Wang, Jay W. Hooper, Linqi Zhang, Qing Zhu
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Monoclonal antibodies (mAbs) targeting the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein have demonstrated clinical efficacy in preventing or treating coronavirus disease 2019 (COVID-19), resulting in the emergency use au
Externí odkaz:
https://doaj.org/article/c44757fcc73249619c8e0e342192a10c
Autor:
Jing-Hui Tian, Nita Patel, Robert Haupt, Haixia Zhou, Stuart Weston, Holly Hammond, James Logue, Alyse D. Portnoff, James Norton, Mimi Guebre-Xabier, Bin Zhou, Kelsey Jacobson, Sonia Maciejewski, Rafia Khatoon, Malgorzata Wisniewska, Will Moffitt, Stefanie Kluepfel-Stahl, Betty Ekechukwu, James Papin, Sarathi Boddapati, C. Jason Wong, Pedro A. Piedra, Matthew B. Frieman, Michael J. Massare, Louis Fries, Karin Lövgren Bengtsson, Linda Stertman, Larry Ellingsworth, Gregory Glenn, Gale Smith
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Here, the authors characterize a SARS-CoV-2 subunit vaccine candidate that contains full-length spike protein stabilized in its prefusion conformation, and show immunogenicity in baboons and protection in mice with Matrix-M adjuvanted vaccine.
Externí odkaz:
https://doaj.org/article/4a4e382fc93a4e5c84f3c4b94fc40a65
Autor:
Robert M Johnson, Jeremy Ardanuy, Holly Hammond, James Logue, Lian Jackson, Lauren Baracco, Marisa McGrath, Carly Dillen, Nita Patel, Gale Smith, Matthew Frieman
Publikováno v:
bioRxiv
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), the causative agent of Coronavirus disease 2019 (COVID-19), emerged in Wuhan, China, in December 2019. As of October 2022, there have been over 625 million confirmed cases of COVID-19, inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1ecb1818dbc8dd25465d9b9e774707c
https://europepmc.org/articles/PMC9603822/
https://europepmc.org/articles/PMC9603822/
Autor:
Megan M. Sperry, Tomiko Oskotsky, Ivana Marić, Shruti Kaushal, Takako Takeda, Viktor Horvath, Rani K. Powers, Melissa Rodas, Brooke Furlong, Mercy Soong, Pranav Prabhala, Girija Goyal, Kenneth E. Carlson, Ronald J. Wong, Idit Kosti, Brian L. Le, James Logue, Holly Hammond, Matthew Frieman, David K. Stevenson, Donald E. Ingber, Marina Sirota, Richard Novak
Publikováno v:
medRxiv
PLoS computational biology, vol 19, iss 5
PLoS computational biology, vol 19, iss 5
SummaryImportanceDrug repurposing requires distinguishing established drug class targets from novel molecule-specific mechanisms and rapidly derisking their therapeutic potential in a time-critical manner, particularly in a pandemic scenario. In resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d30e7c259c82c34fff7c6971e0274968
https://pubmed.ncbi.nlm.nih.gov/35441166
https://pubmed.ncbi.nlm.nih.gov/35441166
Publikováno v:
International Journal of Biological Sciences, Vol 8, Iss 3, Pp 310-327 (2012)
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a promising therapeutic target for treating coronary heart disease. We report a novel antibody 1B20 that binds to PCSK9 with sub-nanomolar affinity and antagonizes PCSK9 function in-vitro. In C
Externí odkaz:
https://doaj.org/article/b0cb7081b55e429b983d35841c324087
Autor:
Linzhao Cheng, Catherine A. Foss, Xiaobing Yu, Doris D. M. Lin, Holly Hammond, Zhaohui Ye, James Fox, Martin G. Pomper
Publikováno v:
Cell Research. 19:370-379
Two new types of lentiviral vectors expressing a reporter transgene encoding either firefly luciferase (fLuc) for bioluminescence imaging or the HSV1 thymidine kinase (HSV1-TK) for radiopharmaceutical-based imaging were constructed to monitor human e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1a7db2ba55094f22c4bf4a552a8605d
https://doi.org/10.1038/cr.2008.329
https://doi.org/10.1038/cr.2008.329