Výsledky vyhledávání - "Holly, Cherwinski"

Establishment of engineered cell-based assays mediating LAG3 and PD1 immune suppression enables potency measurement of blocking antibodies and assessment of signal transduction

Autor: Bhagyashree Bhagwat, Aarron T. Willingham, Holly Cherwinski, Manjiri Sathe, Terrill K. McClanahan, Wolfgang Seghezzi, Rene De Waal Malefyt

Publikováno v: Journal of Immunological Methods. 456:7-14

LAG3 is an important regulator of T cell homeostasis and studies in mouse tumor models have demonstrated that simultaneously antagonizing LAG3 and PD1 can augment tumor-specific T cell responses and induce tumor rejection. The combined use of LAG3 an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b8dbeb4fa8a46d5ab152b795856c36b
https://doi.org/10.1016/j.jim.2018.02.003

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Monoclonal Antibody-Mediated CD200 Receptor Signaling Suppresses Macrophage Activation and Tissue Damage in Experimental Autoimmune Uveoretinitis

Autor: Holly Cherwinski, David A. Copland, Ben J. E. Raveney, Andrew D. Dick, Jonathon D. Sedgwick, Maria C. Jenmalm, Joseph H. Phillips, Claudia J. Calder, Lindsay B. Nicholson

Publikováno v: The American Journal of Pathology. 171:580-588

Macrophage responses are regulated by multiple secreted factors as well as by cell surface receptors, including the inhibitory signals resulting from ligation of myeloid CD200 receptors (CD200R) by the widely distributed CD200. In the absence of CD20

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1064ef15020300fb77ccbbda00c4a1d9
https://doi.org/10.2353/ajpath.2007.070272

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Characterization of the CD200 Receptor Family in Mice and Humans and Their Interactions with CD200

Autor: Man-ru Liu, Gary Brooke, Yaoli Song, Holly Cherwinski, Mildred Foster-Cuevas, Daniel M. Gorman, A. Neil Barclay, M J Puklavec, M. Bigler, Terri McClanahan, Jonathon D. Sedgwick, Maria C. Jenmalm, Joseph H. Phillips, Gavin J. Wright, Marion H. Brown

Publikováno v: The Journal of Immunology. 171:3034-3046

CD200 (OX2) is a broadly distributed cell surface glycoprotein that interacts with a structurally related receptor (CD200R) expressed on rodent myeloid cells and is involved in regulation of macrophage function. We report the first characterization o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71160ddac922d191342e194ce39b8241
https://doi.org/10.4049/jimmunol.171.6.3034

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Ras-induced serine phosphorylation of the focal adhesion protein paxillin is mediated by the Raf→MEK→ERK pathway

Autor: David Stokoe, Melissa A. Woodrow, Douglas Woods, Holly Cherwinski, Martin McMahon

Publikováno v: Experimental Cell Research. 287:325-338

Cells transformed by Ras and Raf display dramatic alterations in cell morphology, adhesion, and intracellular architecture. Consequently, we investigated whether Ras or Raf might influence the behavior of proteins known to be involved in the assembly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f4e22ffa53ee7cb44e46a92f0519c8b
https://doi.org/10.1016/s0014-4827(03)00122-8

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Induction of β3-Integrin Gene Expression by Sustained Activation of the Ras-Regulated Raf–MEK–Extracellular Signal-Regulated Kinase Signaling Pathway

Autor: Arun Bhat, Vicki L. Saylor, Eleni Venetsanakos, Paul F. Bray, Holly Cherwinski, Stephan Gysin, Martine Humbert, Martin McMahon, Douglas Woods

Publikováno v: Molecular and Cellular Biology. 21:3192-3205

Alterations in the expression of integrin receptors for extracellular matrix (ECM) proteins are strongly associated with the acquisition of invasive and/or metastatic properties by human cancer cells. Despite this, comparatively little is known of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0db4aee461513cca51dacf25250d7371
https://doi.org/10.1128/mcb.21.9.3192-3205.2001

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A conditionally-active form of MEK1 results in autocrine transformation of human and mouse hematopoietic cells

Autor: Sean A. Mccarthy, Holly Cherwinski, M. Pearce, James A. McCubrey, Richard A. Franklin, Martin McMahon, Linda S. Steelman, William L. Blalock

Publikováno v: Oncogene. 19:526-536

The Raf/MEK/MAP kinase cascade plays a critical role in transducing growth signals from activated cell surface receptors. Using deltaMEK1:ER, a conditionally-active form of MEK1, we demonstrate the ability of this dual specificity protein kinase to a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e1e5b4b9919deedc6368175f31d8249
https://doi.org/10.1038/sj.onc.1203337

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Complementation of Defective Colony-Stimulating Factor 1 Receptor Signaling and Mitogenesis by Raf and v-Src

Autor: Holly Cherwinski, Natasha Aziz, Martin McMahon

Publikováno v: Molecular and Cellular Biology. 19:1101-1115

Ras-activated signal transduction pathways are implicated in the control of cell proliferation, differentiation, apoptosis, and tumorigenesis, but the molecular mechanisms mediating these diverse functions have yet to be fully elucidated. Conditional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c02318299980e5f29c42a59348b973
https://doi.org/10.1128/mcb.19.2.1101

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Raf-Induced Proliferation or Cell Cycle Arrest Is Determined by the Level of Raf Activity with Arrest Mediated by p21Cip1

Autor: Martin McMahon, Holly Cherwinski, E Bosch, David A.D. Parry, Douglas Woods, Emma Lees

Publikováno v: Molecular and Cellular Biology. 17:5598-5611

The Raf family of protein kinases display differences in their abilities to promote the entry of quiescent NIH 3T3 cells into the S phase of the cell cycle. Although conditional activation of deltaA-Raf:ER promoted cell cycle progression, activation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf53ae2e53d06cab50ae22dd992cc1ba
https://doi.org/10.1128/mcb.17.9.5598

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Regulation of myeloid cell function through the CD200 receptor

Autor: Joseph H. Phillips, Edward P. Bowman, Holly Cherwinski, Jonathon D. Sedgwick, Maria C. Jenmalm

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 176(1)

Myeloid cells play pivotal roles in chronic inflammatory diseases through their broad proinflammatory, destructive, and remodeling capacities. CD200 is widely expressed on a variety of cell types, while the recently identified CD200R is expressed on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e9c19528aa785e84b1489cf5b19d55d
https://pubmed.ncbi.nlm.nih.gov/16365410

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