Zobrazeno 1 - 10
of 1 076
pro vyhledávání: '"Hollis T"'
Autor:
Sahil H Shah, Lucio M Schiapparelli, Yuanhui Ma, Satoshi Yokota, Melissa Atkins, Xin Xia, Evan G Cameron, Thanh Huang, Sarah Saturday, Catalina B Sun, Cara Knasel, Seth Blackshaw, John R Yates, Hollis T Cline, Jeffrey L Goldberg
Publikováno v:
eLife, Vol 11 (2022)
Many neurons in the adult central nervous system, including retinal ganglion cells (RGCs), degenerate and die after injury. Early axon protein and organelle trafficking failure is a key component in many neurodegenerative disorders yet changes to axo
Externí odkaz:
https://doaj.org/article/fff78c4323f14743add545a16bd5e20e
Autor:
Lucio M. Schiapparelli, Pranav Sharma, Hai-Yan He, Jianli Li, Sahil H. Shah, Daniel B. McClatchy, Yuanhui Ma, Han-Hsuan Liu, Jeffrey L. Goldberg, John R. Yates, III, Hollis T. Cline
Publikováno v:
Cell Reports, Vol 38, Iss 4, Pp 110287- (2022)
Summary: Intercellular transfer of toxic proteins between neurons is thought to contribute to neurodegenerative disease, but whether direct interneuronal protein transfer occurs in the healthy brain is not clear. To assess the prevalence and identity
Externí odkaz:
https://doaj.org/article/071d87dde0a841659b062848f74f04db
Autor:
Aaron C Ta, Lin-Chien Huang, Caroline R McKeown, Jennifer E Bestman, Kendall Van Keuren-Jensen, Hollis T Cline
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 12, Iss 1 (2021)
AbstractAmphibian metamorphosis is a transitional period that involves significant changes in the cell-type populations and biological processes occurring in the brain. Analysis of gene expression dynamics during this process may provide insight into
Externí odkaz:
https://doaj.org/article/a984f1b90ab846af9770d9317221f626
Autor:
Sayali V Gore, Eric J James, Lin-chien Huang, Jenn J Park, Andrea Berghella, Adrian C Thompson, Hollis T Cline, Carlos D Aizenman
Publikováno v:
eLife, Vol 10 (2021)
Matrix metalloproteinase-9 (MMP-9) is a secreted endopeptidase targeting extracellular matrix proteins, creating permissive environments for neuronal development and plasticity. Developmental dysregulation of MMP-9 may also lead to neurodevelopmental
Externí odkaz:
https://doaj.org/article/3ade286094534ee698d597e237c62c66
Autor:
Masaki Hiramoto, Hollis T. Cline
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100252- (2021)
Summary: Studies on visual experience-dependent plasticity can benefit tremendously from experimental protocols in which sensory stimulation is precisely controlled for extended periods over which neuronal, circuit, and behavioral plasticity occurs.
Externí odkaz:
https://doaj.org/article/b3a0aae4726b4d309622d0ad25d8453b
Autor:
Masaki Hiramoto, Hollis T. Cline
Publikováno v:
iScience, Vol 23, Iss 6, Pp 101130- (2020)
Summary: Spatial representations of the sensory world are important for brain function. Timing is an essential component of sensory information. Many brain circuits transform the temporal sequence of input activity into spatial maps; however, the mec
Externí odkaz:
https://doaj.org/article/e7b9811be79b4034964c1221cf5fa02e
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Both inhibitory and excitatory input development are shaped by activity, but one may be dependent on the other. Here, the authors examine plasticity of inhibitory inputs in vivo, as well as behavioral consequences in tadpoles where excitatory transmi
Externí odkaz:
https://doaj.org/article/fe7125f9a83347c9871914ef2010d97a
Autor:
Lucio M. Schiapparelli, Sahil H. Shah, Yuanhui Ma, Daniel B. McClatchy, Pranav Sharma, Jianli Li, John R. Yates, III, Jeffrey L. Goldberg, Hollis T. Cline
Publikováno v:
Cell Reports, Vol 28, Iss 7, Pp 1935-1947.e5 (2019)
Summary: The brain processes information and generates cognitive and motor outputs through functions of spatially organized proteins in different types of neurons. More complete knowledge of proteins and their distributions within neuronal compartmen
Externí odkaz:
https://doaj.org/article/de2f5c7fbbc342c1afa889bb0b8d654f
Autor:
Hai-yan He, Hollis T Cline
Publikováno v:
Journal of Experimental Neuroscience, Vol 13 (2019)
The balance between excitation and inhibition in neuronal circuits has drawn more and more attention in recent years, due to its proposed multifaceted functions in the normal neural circuit as well as its potential roles in the etiology of many neuro
Externí odkaz:
https://doaj.org/article/74babb15b1374c80975b28fffd7bcac3
Autor:
Han-Hsuan Liu, Daniel B McClatchy, Lucio Schiapparelli, Wanhua Shen, John R Yates III, Hollis T Cline
Publikováno v:
eLife, Vol 7 (2018)
Experience-dependent synaptic plasticity refines brain circuits during development. To identify novel protein synthesis-dependent mechanisms contributing to experience-dependent plasticity, we conducted a quantitative proteomic screen of the nascent
Externí odkaz:
https://doaj.org/article/0d835f6178594afea8499c342d015dc9