Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Hollis McClory"'
Autor:
Marian DiFiglia, Ellen Sapp, Chiu-Yi Wu, Leah W. Gatune, Gina Nathwani, Xiaolong Wang, Maria Iuliano, Kimberly B. Kegel-Gleason, Hollis McClory, Xueyi Li
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Human huntingtin (Htt) contains 3144 amino acids and has an expanded polyglutamine region near the NH2-terminus in patients with Huntington’s disease. While numerous binding partners have been identified to NH2-terminal Htt, fewer proteins are know
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b04a617e351264bfb08002bf8b50b784
http://europepmc.org/articles/PMC5964228
http://europepmc.org/articles/PMC5964228
Autor:
Marian DiFiglia, Xueyi Li, Kimberly B Kegel, Matthew P Frosch, Nicholas Masso, Kwadwo A Ansong, Jonathan Alexander, Patrick B Reeves, Hollis McClory, Jeffrey S Kimm, Ellen Sapp, Antonio Valencia
Publikováno v:
Human molecular genetics. 26(21)
A mutation in the huntingtin (Htt) gene produces mutant Htt and Huntington's disease (HD), a neurodegenerative disorder. HD patients have oxidative damage in the brain, but the causes are unclear. Compared with controls, we found brain levels of NADP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::690ea1b6d3be455a643b109dfabbec63
https://pubmed.ncbi.nlm.nih.gov/23223017
https://pubmed.ncbi.nlm.nih.gov/23223017
Autor:
Scott A. Shaffer, Seung Kwak, Kwadwo A. Ansong, Marian DiFiglia, Ellen Sapp, Antonio Valencia, Hollis McClory, Neil Aronin, Jeffrey S. Kimm, George J. Yohrling, Karin M. Green, Kimberly B. Kegel
Publikováno v:
Journal of Huntington's Disease. 2:459-475
Synaptic connections are disrupted in patients with Huntington's disease (HD). Synaptosomes from postmortem brain are ideal for synaptic function studies because they are enriched in pre- and post-synaptic proteins important in vesicle fusion, vesicl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6677babc6b123edc7db809a8fce3d53b
https://doi.org/10.3233/jhd-130080
https://doi.org/10.3233/jhd-130080
Publikováno v:
Biochemical and Biophysical Research Communications. 421:727-730
Highlights: Black-Right-Pointing-Pointer Primary Huntington's disease neurons are impaired in taking up glucose. Black-Right-Pointing-Pointer Rab11 modulates glucose uptake in neurons. Black-Right-Pointing-Pointer Increasing Rab11 activity attenuates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7816040a579e289ac4b7f68ad0e7799b
https://doi.org/10.1016/j.bbrc.2012.04.070
https://doi.org/10.1016/j.bbrc.2012.04.070
Autor:
Jonathan Alexander, Ellen Sapp, Antonio Valencia, Kimberly B. Kegel, Jeffrey S. Kimm, Hollis McClory, Matthew P. Frosch, Nicholas Masso, Kwadwo A. Ansong, Patrick B. Reeves, Marian DiFiglia, Xueyi Li
Publikováno v:
Hum Mol Genet
A mutation in the huntingtin (Htt) gene produces mutant Htt and Huntington's disease (HD), a neurodegenerative disorder. HD patients have oxidative damage in the brain, but the causes are unclear. Compared with controls, we found brain levels of NADP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8b6727a2bc5352ab54b3392be506c59
https://pubmed.ncbi.nlm.nih.gov/28973680
https://pubmed.ncbi.nlm.nih.gov/28973680
Autor:
Hollis McClory, Marian DiFiglia, Ellen Sapp, Leah W. Gatune, Ping Wang, Dana T. Williams, Xueyi Li
Publikováno v:
Acta Neuropathologica Communications
Huntington's disease (HD) disturbs glucose metabolism in the brain by poorly understood mechanisms. HD neurons have defective glucose uptake, which is attenuated upon enhancing rab11 activity. Rab11 regulates numerous receptors and transporters traff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4dc5e160e1495cd8d2eae5c968c671f