Assessment of mutations induced by cold atmospheric plasma jet treatment relative to known mutagens in Escherichia coli

Autor: Hollie Hathaway, Robert D. Short, A. Toby A. Jenkins, Naing Tun Thet, Bethany L. Patenall, Maisem Laabei, Amber Young, Sarah L. Allinson

Publikováno v: Mutagenesis. 36:380-387

The main bactericidal components of cold atmospheric plasma (CAP) are thought to be reactive oxygen and nitrogen species (RONS) and UV-radiation, both of which have the capacity to cause DNA damage and mutations. Here, the mutagenic effects of CAP on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e3ca7bc4c7ce27968cc0dfc57f3b33d
https://doi.org/10.1093/mutage/geab030

A small-molecular inhibitor against Proteus mirabilis urease to treat catheter-associated urinary tract infections

Autor: George T. Williams, Sarah L. Allinson, Rachel A. Heylen, A. Toby A. Jenkins, Hollie Hathaway, Bethany L. Patenall, Scarlet Milo, Maisem Laabei, John H. Glancy, Naing Tun Thet

Publikováno v: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)

Infection and blockage of indwelling urinary catheters is significant owing to its high incidence rate and severe medical consequences. Bacterial enzymes are employed as targets for small molecular intervention in human bacterial infections. Urease i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d437ee21512fa63241928b24426f65c7
https://pubmed.ncbi.nlm.nih.gov/33580163

Emerging medical and engineering strategies for the prevention of long-term indwelling catheter blockage

Autor: A. Toby A. Jenkins, Jonathan Nzakizwanayo, Hollie Hathaway, Scarlet Milo, Brian V. Jones

Publikováno v: Milo, S, Nzakizwanayo, J, Hathaway, H J, Jones, B V & Jenkins, A T A 2019, ' Emerging medical and engineering strategies for the prevention of long-term indwelling catheter blockage ', Proceedings of the Institution of Mechanical Engineers, Part H-Journal of Engineering in Medicine, vol. 233, no. 1, pp. 68-83 . https://doi.org/10.1177/0954411918776691

Urinary catheters have been used on an intermittent or indwelling basis for centuries, in order to relieve urinary retention and incontinence. Nevertheless, the use of urinary catheters in the clinical setting is fraught with complication, the most c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ecbed607a2aa8365b464ac54fcbced5
https://doi.org/10.1177/0954411918776691

Recent advances in therapeutic delivery systems of bacteriophage and bacteriophage-encoded endolysins

Autor: Toby A. Jenkins, Scarlet Milo, Hollie Hathaway, J. Mark Sutton

Publikováno v: Hathaway, H, Milo, S, Sutton, J M & Jenkins, T A 2017, ' Recent advances in therapeutic delivery systems of bacteriophage and bacteriophage-encoded endolysins ', Therapeutic Delivery, vol. 8, no. 7, pp. 543-556 . https://doi.org/10.4155/tde-2017-0040

Antibiotics have been the cornerstone of clinical management of bacterial infection since their discovery in the early 20th century. However, their widespread and often indiscriminate use has now led to reports of multidrug resistance becoming global

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb7ba1472a5f85348e1b44d199a0e00c
https://doi.org/10.4155/tde-2017-0040

Limiting Pseudomonas aeruginosa Biofilm Formation Using Cold Atmospheric Pressure Plasma

Autor: Sarah L. Allinson, Bethany L. Patenall, Adam C. Sedgwick, George T. Williams, Naing Tun Thet, Robert D. Short, A. Toby A. Jenkins, Hollie Hathaway, Amber Young

We investigate the ability to disrupt and limit growth biofilms of Pseudomonas aeruginosa using application of cold atmospheric pressure (CAP) plasma. The effect of the bio-film's exposure to a helium (CAP) jet was assessed at varying time points dur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1028f872270016b67a073e74fd3ca9df
https://doi.org/10.1615/PlasmaMed.2018028325