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Synthesis and biological characterisation of sirtuin inhibitors based on the tenovins.

Autor: McCarthy AR; School of Chemistry and Biomedical Sciences Research Complex, University of St. Andrews, North Haugh, St. Andrews, Fife, UK., Pirrie L, Hollick JJ, Ronseaux S, Campbell J, Higgins M, Staples OD, Tran F, Slawin AM, Lain S, Westwood NJ

Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2012 Mar 01; Vol. 20 (5), pp. 1779-93. Date of Electronic Publication: 2012 Jan 12.

Characterization, chemical optimization and anti-tumour activity of a tubulin poison identified by a p53-based phenotypic screen.

Autor: Staples OD; Department of Surgery and Molecular Oncology, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, UK., Hollick JJ, Campbell J, Higgins M, McCarthy AR, Appleyard V, Murray KE, Baker L, Thompson A, Ronseaux S, Slawin AM, Lane DP, Westwood NJ, Lain S

Publikováno v: Cell cycle (Georgetown, Tex.) [Cell Cycle] 2008 Nov 01; Vol. 7 (21), pp. 3417-27. Date of Electronic Publication: 2008 Nov 15.

Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.

Autor: Hollick JJ; Northern Institute for Cancer Research, School of Natural Sciences-Chemistry, Bedson Building, Newcastle University, Newcastle upon Tyne NE1 7RU, United Kingdom., Rigoreau LJ, Cano-Soumillac C, Cockcroft X, Curtin NJ, Frigerio M, Golding BT, Guiard S, Hardcastle IR, Hickson I, Hummersone MG, Menear KA, Martin NM, Matthews I, Newell DR, Ord R, Richardson CJ, Smith GC, Griffin RJ

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2007 Apr 19; Vol. 50 (8), pp. 1958-72. Date of Electronic Publication: 2007 Mar 20.