Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Holli A. Giebler"'
Autor:
Whitney R. Baldwin, Holli A. Giebler, Janae L. Stovall, Ginger Young, Kelly J. Bohning, Hansi J. Dean, Jill A. Livengood, Claire Y.-H. Huang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Here the authors generate a live-attenuated Zika vaccine based on a clinically proven dengue virus serotype-2 vaccine backbone and show that one dose protects mice and non-human primates from Zika virus infection.
Externí odkaz:
https://doaj.org/article/b8778b7cdf1e454aa4f4bbc9276e3404
Autor:
Sheena D'Arcy, Karolin Luger, Catherine A. Radebaugh, Liangquan Huang, Xu Chen, Jennifer K. Nyborg, Holli A. Giebler, Daniel D Krzizike, Laurie A. Stargell
Histone chaperones, like nucleosome assembly protein 1 (Nap1), play a critical role in the maintenance of chromatin architecture. Here, we use the GAL locus in Saccharomyces cerevisiae to investigate the influence of Nap1 on chromatin structure and h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba34e4fa4092438b52aac67da0803ce0
https://europepmc.org/articles/PMC4836277/
https://europepmc.org/articles/PMC4836277/
Publikováno v:
Journal of Biological Chemistry. 274:26321-26328
The pleiotropic cellular coactivator CREB binding protein (CBP) plays a critical role in supporting p53-dependent tumor suppressor functions. p53 has been shown to directly interact with a carboxyl-terminal region of CBP for recruitment of the coacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2190caf9e9a5ad8ab408aa4907e75fc6
https://doi.org/10.1074/jbc.274.37.26321
https://doi.org/10.1074/jbc.274.37.26321
Publikováno v:
Molecular and Cellular Biology. 18:721-731
Efficient human T-cell leukemia virus type 1 (HTLV-1) replication and viral gene expression are dependent upon the virally encoded oncoprotein Tax. To activate HTLV-1 transcription, Tax interacts with the cellular DNA binding protein cyclic AMP-respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49df702ad8d5798ee8f103dd6fd90016
https://doi.org/10.1128/mcb.18.2.721
https://doi.org/10.1128/mcb.18.2.721
Publikováno v:
Journal of Biological Chemistry. 270:28503-28506
The human T-cell leukemia virus type I oncoprotein Tax transcriptionally deregulates a wide variety of viral and cellular genes. Tax deregulation of gene expression is mediated through interaction with a variety of structurally unrelated cellular tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff91b1f0e296449a9d79f01f534b61c
https://doi.org/10.1074/jbc.270.48.28503
https://doi.org/10.1074/jbc.270.48.28503
Publikováno v:
Journal of Biological Chemistry. 270:12814-12822
The human T-cell leukemia virus type I (HTLV-I) is the causative agent of an aggressive T-cell malignancy in humans. While the virus appears to maintain a state of latency in most infected cells, high level virion production is an essential step in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21477d690bdb586e8199da66d7e76b5d
https://doi.org/10.1074/jbc.270.21.12814
https://doi.org/10.1074/jbc.270.21.12814
Autor:
Jennifer K. Nyborg, Holli A. Giebler, Young-Mi Kim, Julita A. Ramírez, Jeanne E. Mick, Jian-Ping Yan
Publikováno v:
The Journal of biological chemistry. 282(26)
Transcriptional activation of human T-cell leukemia virus type 1 (HTLV-1) is mediated by the viral oncoprotein Tax, which utilizes cellular transcriptional machinery to perform this function. The viral promoter carries three cyclic AMP-response eleme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8c12bd0a14e225dbf1d85a4873c751e
https://pubmed.ncbi.nlm.nih.gov/17449469
https://pubmed.ncbi.nlm.nih.gov/17449469
Autor:
Philip A. Cole, Sara A. Georges, Karolin Luger, Holli A. Giebler, Jennifer K. Nyborg, Paul J. Laybourn
Publikováno v:
Molecular and cellular biology. 23(10)
Robust transcription of human T-cell leukemia virus type 1 (HTLV-1) genome requires the viral transactivator Tax. Although Tax has been previously shown to interact with the KIX domain of CBP/p300 in vitro, the precise functional relevance of this in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd3f05bc1a3d8ae0105251db3354fb52
https://pubmed.ncbi.nlm.nih.gov/12724399
https://pubmed.ncbi.nlm.nih.gov/12724399
CREB binding protein (CBP) is a 270-kDa nuclear protein required for activated transcription of a large number of cellular genes. Although CBP was originally discovered through its interaction with phosphorylated CREB (pCREB), it is utilized by a mul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2362370e79d07b103a1ae6da3c4df4e
https://europepmc.org/articles/PMC85936/
https://europepmc.org/articles/PMC85936/
Publikováno v:
Journal of molecular biology. 281(3)
The oncoprotein Tax, encoded by the human T-cell leukemia virus type I (HTLV-I), is required for high-level viral transcription and is strongly linked to HTLV-I-associated malignant transformation. Recent evidence suggests that Tax stimulates HTLV-I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39ffa8c25c4ec3c555eec5b11641ffda
https://pubmed.ncbi.nlm.nih.gov/9698555
https://pubmed.ncbi.nlm.nih.gov/9698555