Corticostriatal Maldevelopment in the R6/2 Mouse Model of Juvenile Huntington's Disease.

Autor: Cepeda C, Holley SM, Barry J, Oikonomou KD, Yazon VW, Peng A, Argueta D, Levine MS

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Oct 18. Date of Electronic Publication: 2024 Oct 18.

Transplanted human neural stem cells rescue phenotypes in zQ175 Huntington's disease mice and innervate the striatum.

Autor: Holley SM; Intellectual and Developmental Disabilities Research Center, Semel Institute for Neuroscience & Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA., Reidling JC; Institute for Memory Impairment and Neurological Disorders, University of California Irvine, Irvine, CA 92697, USA., Cepeda C; Intellectual and Developmental Disabilities Research Center, Semel Institute for Neuroscience & Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA., Wu J; Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA., Lim RG; Institute for Memory Impairment and Neurological Disorders, University of California Irvine, Irvine, CA 92697, USA., Lau A; Psychiatry & Human Behavior, University of California Irvine, Irvine, CA 92697, USA., Moore C; Portland VA Medical Center, Portland, OR 97239, USA., Miramontes R; Institute for Memory Impairment and Neurological Disorders, University of California Irvine, Irvine, CA 92697, USA., Fury B; Institute for Regenerative Cures, University of California Davis, Sacramento, CA 95817, USA., Orellana I; Institute for Memory Impairment and Neurological Disorders, University of California Irvine, Irvine, CA 92697, USA., Neel M; Department of Pathology & Laboratory Medicine, University of California, Irvine, Irvine, CA 92697, USA., Coleal-Bergum D; Institute for Regenerative Cures, University of California Davis, Sacramento, CA 95817, USA., Monuki ES; Department of Pathology & Laboratory Medicine, University of California, Irvine, Irvine, CA 92697, USA; Sue and Bill Gross Stem Cell Center, University of California Irvine, Irvine, CA 92697, USA., Bauer G; Institute for Regenerative Cures, University of California Davis, Sacramento, CA 95817, USA., Meshul CK; Portland VA Medical Center, Portland, OR 97239, USA; Oregon Health & Science University, Department of Behavioral Neuroscience and Pathology, Portland, OR 97239, USA., Levine MS; Intellectual and Developmental Disabilities Research Center, Semel Institute for Neuroscience & Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA; Brain Research Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA., Thompson LM; Institute for Memory Impairment and Neurological Disorders, University of California Irvine, Irvine, CA 92697, USA; Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA; Psychiatry & Human Behavior, University of California Irvine, Irvine, CA 92697, USA; Sue and Bill Gross Stem Cell Center, University of California Irvine, Irvine, CA 92697, USA; Department of Neurobiology & Behavior University of California Irvine, Irvine, CA 92697, USA. Electronic address: lmthomps@uci.edu.

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2023 Dec 06; Vol. 31 (12), pp. 3545-3563. Date of Electronic Publication: 2023 Oct 07.

A bidirectional corticoamygdala circuit for the encoding and retrieval of detailed reward memories.

Autor: Sias AC; Department of Psychology, University of California, Los Angeles, Los Angeles, United States., Morse AK; Department of Psychology, University of California, Los Angeles, Los Angeles, United States., Wang S; Department of Psychology, University of California, Los Angeles, Los Angeles, United States., Greenfield VY; Department of Psychology, University of California, Los Angeles, Los Angeles, United States., Goodpaster CM; Department of Psychology, University of California, Los Angeles, Los Angeles, United States., Wrenn TM; Department of Psychology, University of California, Los Angeles, Los Angeles, United States., Wikenheiser AM; Department of Psychology, University of California, Los Angeles, Los Angeles, United States.; Brain Research Institute, University of California, Los Angeles, Los Angeles, United States.; Integrative Center for Learning and Memory, University of California, Los Angeles, Los Angeles, United States., Holley SM; Intellectual and Developmental Disabilities Research Center, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States., Cepeda C; Intellectual and Developmental Disabilities Research Center, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States., Levine MS; Brain Research Institute, University of California, Los Angeles, Los Angeles, United States.; Intellectual and Developmental Disabilities Research Center, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States., Wassum KM; Department of Psychology, University of California, Los Angeles, Los Angeles, United States.; Brain Research Institute, University of California, Los Angeles, Los Angeles, United States.; Integrative Center for Learning and Memory, University of California, Los Angeles, Los Angeles, United States.; Integrative Center for Addictive Disorders, University of California, Los Angeles, Los Angeles, United States.

Publikováno v: ELife [Elife] 2021 Jun 18; Vol. 10. Date of Electronic Publication: 2021 Jun 18.

Major Contribution of Somatostatin-Expressing Interneurons and Cannabinoid Receptors to Increased GABA Synaptic Activity in the Striatum of Huntington's Disease Mice.

Autor: Holley SM; Intellectual and Developmental Disabilities Research Center, Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, United States., Galvan L; Intellectual and Developmental Disabilities Research Center, Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, United States., Kamdjou T; Intellectual and Developmental Disabilities Research Center, Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, United States., Dong A; Intellectual and Developmental Disabilities Research Center, Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, United States., Levine MS; Intellectual and Developmental Disabilities Research Center, Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, United States., Cepeda C; Intellectual and Developmental Disabilities Research Center, Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, United States.

Publikováno v: Frontiers in synaptic neuroscience [Front Synaptic Neurosci] 2019 May 14; Vol. 11, pp. 14. Date of Electronic Publication: 2019 May 14 (Print Publication: 2019).

Striatal GABAergic interneuron dysfunction in the Q175 mouse model of Huntington's disease.

Autor: Holley SM; Intellectual and Developmental Disabilities Research Center, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, Brain Research Institute, UCLA, Los Angeles, California., Galvan L; Intellectual and Developmental Disabilities Research Center, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, Brain Research Institute, UCLA, Los Angeles, California., Kamdjou T; Intellectual and Developmental Disabilities Research Center, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, Brain Research Institute, UCLA, Los Angeles, California., Cepeda C; Intellectual and Developmental Disabilities Research Center, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, Brain Research Institute, UCLA, Los Angeles, California., Levine MS; Intellectual and Developmental Disabilities Research Center, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, Brain Research Institute, UCLA, Los Angeles, California.

Publikováno v: The European journal of neuroscience [Eur J Neurosci] 2019 Jan; Vol. 49 (1), pp. 79-93. Date of Electronic Publication: 2018 Dec 10.