First-in-human intracochlear application of human stromal cell-derived extracellular vesicles

Autor: Warnecke, A., Prenzler, N., Harre, J., Köhl, U., Gärtner, L., Lenarz, T., Laner-Plamberger, S., Wietzorrek, G., Staecker, H., Lassacher, T., Hollerweger, J., Gimona, M., Rohde, E.

Extracellular vesicles (EVs) derived from the secretome of human mesenchymal stromal cells (MSC) contain numerous factors that are known to exert anti-inflammatory effects. MSC-EVs may serve as promising cell-based therapeutics for the inner ear to a

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https://publica.fraunhofer.de/handle/publica/270543

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Extracellular vesicles from human multipotent stromal cells protect against hearing loss after noise trauma in vivo.

Autor: Warnecke A; Department of Otorhinolaryngology, Head and Neck Surgery, Hannover Medical School, Hannover, Germany., Harre J; Department of Otorhinolaryngology, Head and Neck Surgery, Hannover Medical School, Hannover, Germany., Staecker H; Department of Otolaryngology, Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, Kansas., Prenzler N; Department of Otorhinolaryngology, Head and Neck Surgery, Hannover Medical School, Hannover, Germany., Strunk D; Institute of Experimental and Clinical Cell Therapy, Spinal Cord Injury and Tissue Regeneration Centre Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria., Couillard-Despres S; Institute of Experimental Neuroregeneration, Spinal Cord Injury and Tissue Regeneration Centre Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria.; Austrian Cluster for Tissue Regeneration, Vienna, Austria., Romanelli P; Institute of Experimental Neuroregeneration, Spinal Cord Injury and Tissue Regeneration Centre Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria., Hollerweger J; GMP Unit, Spinal Cord Injury and Tissue Regeneration Centre Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria., Lassacher T; GMP Unit, Spinal Cord Injury and Tissue Regeneration Centre Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria., Auer D; GMP Unit, Spinal Cord Injury and Tissue Regeneration Centre Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria., Pachler K; Research Program 'Nanovesicular Therapies,', Paracelsus Medical University (PMU), Salzburg, Austria., Wietzorrek G; Institute of Molecular and Cellular Pharmacology, Medical University of Innsbruck, Innsbruck, Austria., Köhl U; Institute of Cellular Therapeutics, Hannover Medical School and Clinical Immunology, University Leipzig, Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany., Lenarz T; Department of Otorhinolaryngology, Head and Neck Surgery, Hannover Medical School, Hannover, Germany., Schallmoser K; GMP Unit, Spinal Cord Injury and Tissue Regeneration Centre Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria.; Department of Transfusion Medicine, University Hospital, Salzburger Landeskliniken GesmbH (SALK) and Paracelsus Medical University (PMU), Salzburg, Austria., Laner-Plamberger S; Department of Transfusion Medicine, University Hospital, Salzburger Landeskliniken GesmbH (SALK) and Paracelsus Medical University (PMU), Salzburg, Austria., Falk CS; Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany., Rohde E; GMP Unit, Spinal Cord Injury and Tissue Regeneration Centre Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria.; Department of Transfusion Medicine, University Hospital, Salzburger Landeskliniken GesmbH (SALK) and Paracelsus Medical University (PMU), Salzburg, Austria., Gimona M; GMP Unit, Spinal Cord Injury and Tissue Regeneration Centre Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria.; Research Program 'Nanovesicular Therapies,', Paracelsus Medical University (PMU), Salzburg, Austria.

Publikováno v: Clinical and translational medicine [Clin Transl Med] 2020 Dec; Vol. 10 (8), pp. e262.