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Convergent selective signaling impairment exposes the pathogenicity of latrophilin-3 missense variants linked to inheritable ADHD susceptibility.

Autor: Moreno-Salinas AL; Department of Cell Biology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav-IPN), México City, México., Holleran BJ; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Canada., Ojeda-Muñiz EY; Department of Cell Biology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav-IPN), México City, México., Correoso-Braña KG; Department of Cell Biology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav-IPN), México City, México., Ribalta-Mena S; Department of Cell Biology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav-IPN), México City, México., Ovando-Zambrano JC; Department of Physiology, Biophysics and Neurosciences, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav-IPN), México City, México., Leduc R; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Canada., Boucard AA; Department of Cell Biology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav-IPN), México City, México. antony.boucard@cinvestav.mx.

Publikováno v: Molecular psychiatry [Mol Psychiatry] 2022 May; Vol. 27 (5), pp. 2425-2438. Date of Electronic Publication: 2022 Apr 07.

Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists.

Autor: Claff T; iHuman Institute, ShanghaiTech University, Ren Building, 393 Middle Huaxia Rd, Pudong, Shanghai 201210, China.; PharmaCenter Bonn, University of Bonn, Pharmaceutical Chemistry I, An der Immenburg 4, D-53121 Bonn, Germany., Yu J; iHuman Institute, ShanghaiTech University, Ren Building, 393 Middle Huaxia Rd, Pudong, Shanghai 201210, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.; CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.; University of the Chinese Academy of Sciences, Beijing 100049, China., Blais V; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Centre de Recherche du CHUS, Université de Sherbrooke, 3001 12e Avenue Nord, Sherbrooke, Quebec J1H 5N4, Canada., Patel N; Departments of Biological Sciences and Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA., Martin C; Research Group of Organic Chemistry, Departments of Chemistry and Bioengineering Sciences, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium., Wu L; iHuman Institute, ShanghaiTech University, Ren Building, 393 Middle Huaxia Rd, Pudong, Shanghai 201210, China., Han GW; Departments of Biological Sciences and Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA., Holleran BJ; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Centre de Recherche du CHUS, Université de Sherbrooke, 3001 12e Avenue Nord, Sherbrooke, Quebec J1H 5N4, Canada., Van der Poorten O; Research Group of Organic Chemistry, Departments of Chemistry and Bioengineering Sciences, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium., White KL; Departments of Biological Sciences and Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA., Hanson MA; GPCR Consortium, San Marcos, CA 92078, USA., Sarret P; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Centre de Recherche du CHUS, Université de Sherbrooke, 3001 12e Avenue Nord, Sherbrooke, Quebec J1H 5N4, Canada., Gendron L; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Centre de Recherche du CHUS, Université de Sherbrooke, 3001 12e Avenue Nord, Sherbrooke, Quebec J1H 5N4, Canada., Cherezov V; Departments of Biological Sciences and Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA., Katritch V; Departments of Biological Sciences and Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA., Ballet S; Research Group of Organic Chemistry, Departments of Chemistry and Bioengineering Sciences, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium., Liu ZJ; iHuman Institute, ShanghaiTech University, Ren Building, 393 Middle Huaxia Rd, Pudong, Shanghai 201210, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China., Müller CE; PharmaCenter Bonn, University of Bonn, Pharmaceutical Chemistry I, An der Immenburg 4, D-53121 Bonn, Germany., Stevens RC; iHuman Institute, ShanghaiTech University, Ren Building, 393 Middle Huaxia Rd, Pudong, Shanghai 201210, China.; Departments of Biological Sciences and Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA.

Publikováno v: Science advances [Sci Adv] 2019 Nov 27; Vol. 5 (11), pp. eaax9115. Date of Electronic Publication: 2019 Nov 27 (Print Publication: 2019).

N-Guanidyl and C-Tetrazole Leu-Enkephalin Derivatives: Efficient Mu and Delta Opioid Receptor Agonists with Improved Pharmacological Properties.

Autor: Beaudeau JL, Blais V, Holleran BJ, Bergeron A, Piñeyro G; Département de Psychiatrie, Centre de Recherche du CHU Ste-Justine , Université de Montréal , Montréal , Québec H3T 1J4 , Canada., Guérin B, Gendron L, Dory YL

Publikováno v: ACS chemical neuroscience [ACS Chem Neurosci] 2019 Mar 20; Vol. 10 (3), pp. 1615-1626. Date of Electronic Publication: 2019 Jan 23.

GRK2 knockdown in mice exacerbates kidney injury and alters renal mechanisms of blood pressure regulation.

Autor: Tutunea-Fatan E; Vascular Biology Group, Robarts Research Institute, University of Western Ontario, London, Ontario, N6A 5K8, Canada.; Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, N6A 5K8, Canada., Abd-Elrahman KS; University of Ottawa Brain and Mind Research Institute and Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, K1H 8M5, Canada.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, 21521, Egypt., Thibodeau JF; University of Ottawa Brain and Mind Research Institute and Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, K1H 8M5, Canada.; Kidney Research Center, Ottawa Hospital Research Institute, Ottawa, Ontario, K1H 8M5, Canada., Holterman CE; Kidney Research Center, Ottawa Hospital Research Institute, Ottawa, Ontario, K1H 8M5, Canada., Holleran BJ; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec, J1H 5N4, Canada., Leduc R; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec, J1H 5N4, Canada., Kennedy CRJ; University of Ottawa Brain and Mind Research Institute and Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, K1H 8M5, Canada.; Kidney Research Center, Ottawa Hospital Research Institute, Ottawa, Ontario, K1H 8M5, Canada., Gros R; Vascular Biology Group, Robarts Research Institute, University of Western Ontario, London, Ontario, N6A 5K8, Canada.; Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, N6A 5K8, Canada., Ferguson SSG; University of Ottawa Brain and Mind Research Institute and Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, K1H 8M5, Canada. sferguso@uottawa.ca.

Publikováno v: Scientific reports [Sci Rep] 2018 Jul 30; Vol. 8 (1), pp. 11415. Date of Electronic Publication: 2018 Jul 30.