Identification of Potent and Selective RIPK2 Inhibitors for the Treatment of Inflammatory Diseases.

Autor: He X; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States., Da Ros S; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States., Nelson J; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States., Zhu X; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States., Jiang T; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States., Okram B; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States., Jiang S; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States., Michellys PY; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States., Iskandar M; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States., Espinola S; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States., Jia Y; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States., Bursulaya B; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States., Kreusch A; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States., Gao MY; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States., Spraggon G; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States., Baaten J; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States., Clemmer L; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States., Meeusen S; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States., Huang D; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States., Hill R; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States., Nguyen-Tran V; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States., Fathman J; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States., Liu B; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States., Tuntland T; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States., Gordon P; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States., Hollenbeck T; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States., Ng K; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States., Shi J; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States., Bordone L; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States., Liu H; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2017 Sep 27; Vol. 8 (10), pp. 1048-1053. Date of Electronic Publication: 2017 Sep 27 (Print Publication: 2017).

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Lead optimization of imidazopyrazines: a new class of antimalarial with activity on Plasmodium liver stages.

Autor: Zou B; Novartis Institute for Tropical Diseases , 10 Biopolis Road #05-01 Chromos, 138670 Singapore., Nagle A; Genomics Institute of the Novartis Research Foundation , San Diego, California 92121, United States., Chatterjee AK; Genomics Institute of the Novartis Research Foundation , San Diego, California 92121, United States., Leong SY; Novartis Institute for Tropical Diseases , 10 Biopolis Road #05-01 Chromos, 138670 Singapore., Tan LJ; Novartis Institute for Tropical Diseases , 10 Biopolis Road #05-01 Chromos, 138670 Singapore., Sim WL; Novartis Institute for Tropical Diseases , 10 Biopolis Road #05-01 Chromos, 138670 Singapore., Mishra P; Genomics Institute of the Novartis Research Foundation , San Diego, California 92121, United States., Guntapalli P; Genomics Institute of the Novartis Research Foundation , San Diego, California 92121, United States., Tully DC; Genomics Institute of the Novartis Research Foundation , San Diego, California 92121, United States., Lakshminarayana SB; Novartis Institute for Tropical Diseases , 10 Biopolis Road #05-01 Chromos, 138670 Singapore., Lim CS; Novartis Institute for Tropical Diseases , 10 Biopolis Road #05-01 Chromos, 138670 Singapore., Tan YC; Novartis Institute for Tropical Diseases , 10 Biopolis Road #05-01 Chromos, 138670 Singapore., Abas SN; Novartis Institute for Tropical Diseases , 10 Biopolis Road #05-01 Chromos, 138670 Singapore., Bodenreider C; Novartis Institute for Tropical Diseases , 10 Biopolis Road #05-01 Chromos, 138670 Singapore., Kuhen KL; Genomics Institute of the Novartis Research Foundation , San Diego, California 92121, United States., Gagaring K; Genomics Institute of the Novartis Research Foundation , San Diego, California 92121, United States., Borboa R; Genomics Institute of the Novartis Research Foundation , San Diego, California 92121, United States., Chang J; Genomics Institute of the Novartis Research Foundation , San Diego, California 92121, United States., Li C; Genomics Institute of the Novartis Research Foundation , San Diego, California 92121, United States., Hollenbeck T; Genomics Institute of the Novartis Research Foundation , San Diego, California 92121, United States., Tuntland T; Genomics Institute of the Novartis Research Foundation , San Diego, California 92121, United States., Zeeman AM; Department of Parasitology, Biomedical Primate Research Centre , 2280 GH Rijswijk, The Netherlands., Kocken CH; Department of Parasitology, Biomedical Primate Research Centre , 2280 GH Rijswijk, The Netherlands., McNamara C; Genomics Institute of the Novartis Research Foundation , San Diego, California 92121, United States., Kato N; Genomics Institute of the Novartis Research Foundation , San Diego, California 92121, United States., Winzeler EA; Genomics Institute of the Novartis Research Foundation , San Diego, California 92121, United States ; Department of Pediatrics, School of Medicine, University of California , San Diego, California 92093, United States., Yeung BK; Novartis Institute for Tropical Diseases , 10 Biopolis Road #05-01 Chromos, 138670 Singapore., Diagana TT; Novartis Institute for Tropical Diseases , 10 Biopolis Road #05-01 Chromos, 138670 Singapore., Smith PW; Novartis Institute for Tropical Diseases , 10 Biopolis Road #05-01 Chromos, 138670 Singapore., Roland J; Genomics Institute of the Novartis Research Foundation , San Diego, California 92121, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2014 Jul 06; Vol. 5 (8), pp. 947-50. Date of Electronic Publication: 2014 Jul 06 (Print Publication: 2014).

Characterization of a novel, brain-penetrating CB1 receptor inverse agonist: metabolic profile in diet-induced obese models and aspects of central activity.

Autor: Jacobson LH; Neuroscience Disease Area, Novartis Institutes for BioMedical Research, Basel, Switzerland. laura.jacobson@novartis.com, Commerford SR, Gerber SP, Chen YA, Dardik B, Chaperon F, Schwartzkopf C, Nguyen-Tran V, Hollenbeck T, McNamara P, He X, Liu H, Seidel HM, Jaton AL, Gromada J, Teixeira S

Publikováno v: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2011 Dec; Vol. 384 (6), pp. 565-81. Date of Electronic Publication: 2011 Sep 25.