Výsledky vyhledávání - "Holland Cheng"

Akademický článek

Early mucosal sensing of SIV infection by paneth cells induces IL-1β production and initiates gut epithelial disruption.

Autor: Lauren A Hirao, Irina Grishina, Olivier Bourry, William K Hu, Monsicha Somrit, Sumathi Sankaran-Walters, Chris A Gaulke, Anne N Fenton, Jay A Li, Robert W Crawford, Frank Chuang, Ross Tarara, Maria L Marco, Andreas J Bäumler, Holland Cheng, Satya Dandekar

Publikováno v: PLoS Pathogens, Vol 10, Iss 8, p e1004311 (2014)

HIV causes rapid CD4+ T cell depletion in the gut mucosa, resulting in immune deficiency and defects in the intestinal epithelial barrier. Breakdown in gut barrier integrity is linked to chronic inflammation and disease progression. However, the earl

Externí odkaz: https://doaj.org/article/39e65dcf61714c3bb375b0960c97f274

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Elektronická kniha

Structure-based Study Of Viral Replication (With Cd-rom)

Autor: R Holland Cheng, Tatsuo Miyamura

This book addresses the innovative themes in characterizing the cellular membrane platforms and intracellular networking, as well as the architectural aspects of cell compartments mediated by the entry and replication cycles of viruses. The instrumen

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Elektronická kniha

Conformational Proteomics Of Macromolecular Architecture: Approaching The Structure Of Large Molecular Assemblies And Their Mechanisms Of Action (With Cd-rom)

Autor: R Holland Cheng, Lena Hammar

Biological processes involving large macromolecular assemblies are thought to be a dynamic consequence of cooperativity and metastability. The folding of a peptide chain creates local environments from which “activity” can emerge. In the same way

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Akademický článek

NDAT Targets PI3K-Mediated PD-L1 Upregulation to Reduce Proliferation in Gefitinib-Resistant Colorectal Cancer

Publikováno v: Cells, Vol 9, Iss 8, p 1830 (2020)

The property of drug-resistance may attenuate clinical therapy in cancer cells, such as chemoresistance to gefitinib in colon cancer cells. In previous studies, overexpression of PD-L1 causes proliferation and metastasis in cancer cells; therefore, t

Externí odkaz: https://doaj.org/article/a2d87109f6454f45a616688aaa73d59b

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Akademický článek

Structural Insight into CVB3-VLP Non-Adjuvanted Vaccine

Autor: Minna M. Hankaniemi, Mo A. Baikoghli, Virginia M. Stone, Li Xing, Outi Väätäinen, Saana Soppela, Amirbabak Sioofy-Khojine, Niila V. V. Saarinen, Tingwei Ou, Brandon Anson, Heikki Hyöty, Varpu Marjomäki, Malin Flodström-Tullberg, R. Holland Cheng, Vesa P. Hytönen, Olli H. Laitinen

Publikováno v: Microorganisms, Vol 8, Iss 9, p 1287 (2020)

Coxsackievirus B (CVB) enteroviruses are common pathogens that can cause acute and chronic myocarditis, dilated cardiomyopathy, aseptic meningitis, and they are hypothesized to be a causal factor in type 1 diabetes. The licensed enterovirus vaccines

Externí odkaz: https://doaj.org/article/2ce670a6a010445b87d452f5a9fe7e9e

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Akademický článek

Developmentally Regulated Post-translational Modification of Nucleoplasmin Controls Histone Sequestration and Deposition

Autor: Takashi Onikubo, Joshua J. Nicklay, Li Xing, Christopher Warren, Brandon Anson, Wei-Lin Wang, Emmanuel S. Burgos, Sophie E. Ruff, Jeffrey Shabanowitz, R. Holland Cheng, Donald F. Hunt, David Shechter

Publikováno v: Cell Reports, Vol 10, Iss 10, Pp 1735-1748 (2015)

Nucleoplasmin (Npm) is an abundant histone chaperone in vertebrate oocytes and embryos. During embryogenesis, regulation of Npm histone binding is critical for its function in storing and releasing maternal histones to establish and maintain the zygo

Externí odkaz: https://doaj.org/article/02eaa4356aff42ffabba45ee976056e1

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