Zobrazeno 1 - 10
of 233
pro vyhledávání: '"Holger Stephan"'
Autor:
Liliana R. Loureiro, Lydia Hoffmann, Christin Neuber, Luise Rupp, Claudia Arndt, Alexandra Kegler, Manja Kubeil, Christoph E. Hagemeyer, Holger Stephan, Marc Schmitz, Anja Feldmann, Michael Bachmann
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-17 (2023)
Abstract Background Chimeric antigen receptor (CAR) T-cells are a promising approach in cancer immunotherapy, particularly for treating hematologic malignancies. Yet, their effectiveness is limited when tackling solid tumors, where immune cell infilt
Externí odkaz:
https://doaj.org/article/40cdac5b7b9a489091bc53905b399ab5
Publikováno v:
Healthcare, Vol 11, Iss 5, p 741 (2023)
Recommendations for conventional strength training are well described, and the volume of research on whole-body electromyostimulation training (WB-EMS) is growing. The aim of the present study was to investigate whether active exercise movements duri
Externí odkaz:
https://doaj.org/article/d1f52606187c473199a2c1c6f2a81626
Publikováno v:
Biology, Vol 11, Iss 4, p 593 (2022)
Electromyostimulation has been shown to intensify exercise when superimposed on cycling. However, little is known about the application during running, which might help to prevent injuries linked to high running volumes, as intensification of running
Externí odkaz:
https://doaj.org/article/40dea567dcc44baa8876308ae43f3cfe
Autor:
Manja Kubeil, Irma Ivette Santana Martínez, Michael Bachmann, Klaus Kopka, Kellie L. Tuck, Holger Stephan
Publikováno v:
Pharmaceuticals, Vol 15, Iss 4, p 432 (2022)
Molecular imaging offers the possibility to investigate biological and biochemical processes non-invasively and to obtain information on both anatomy and dysfunctions. Based on the data obtained, a fundamental understanding of various disease process
Externí odkaz:
https://doaj.org/article/ac96f5cb53204ce0a7c9cef44a2ff19a
Autor:
Martin Hruby, Irma Ivette Santana Martínez, Holger Stephan, Pavla Pouckova, Jiri Benes, Petr Stepanek
Publikováno v:
Polymers, Vol 13, Iss 22, p 3969 (2021)
Iron and copper are essential micronutrients needed for the proper function of every cell. However, in excessive amounts, these elements are toxic, as they may cause oxidative stress, resulting in damage to the liver and other organs. This may happen
Externí odkaz:
https://doaj.org/article/9f4c59362f0e453cbcad55855ae255cf
Autor:
Ralf Bergmann, Manja Kubeil, Kristof Zarschler, Sandeep Chhabra, Rajeev B. Tajhya, Christine Beeton, Michael W. Pennington, Michael Bachmann, Raymond S. Norton, Holger Stephan
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract The peptide HsTX1[R14A] is a potent and selective blocker of the voltage-gated potassium channel Kv1.3, which is a highly promising target for the treatment of autoimmune diseases and other conditions. In order to assess the biodistribution
Externí odkaz:
https://doaj.org/article/df49b90ff84b43d9acf32897f9f258e4
Autor:
Brühlmann, Santiago, Kubeil, Manja, Cieslik, Patrick, Kopp, Ina, Bachmann, Michael, Kopka, Klaus, Holger, Stephan, Comba, Peter
Publikováno v:
In Nuclear Medicine and Biology November-December 2023 126-127 Supplement
Autor:
Lily Southcott, Holger Stephan, Chris Orvig, María de Guadalupe Jaraquemada-Peláez, Brian O. Patrick, Lily Li
Publikováno v:
Inorganic Chemistry. 60:18082-18093
H4pypa is a nonadentate nonmacrocyclic chelator, which previously demonstrated high affinity for scandium-44, lutetium-177, and indium-111. Herein, we report the highly stable binary [Zr(pypa)] complex; the nonradioactive complex was synthesized and
Autor:
Patrick Cieslik, Manja Kubeil, Kristof Zarschler, Martin Ullrich, Florian Brandt, Karl Anger, Hubert Wadepohl, Klaus Kopka, Michael Bachmann, Jens Pietzsch, Holger Stephan, Peter Comba
Publikováno v:
Journal of the American Chemical Society 144(2022)47, 21555-21567
We report a nonadentate bispidine (3,7-diazabicyclo[3.3.1]nonane) that unveils the potential to bind theranostically relevant radionuclides, including indium-111, lutetium-177 and actinium-225 at mild labeling conditions. This radiopharmaceutical can
Autor:
Hua Yang, Chris Orvig, Luke Wharton, Manja Kubeil, Xiaozhu Wang, Holger Stephan, Lily Southcott, Kristof Zarschler, María de Guadalupe Jaraquemada-Peláez, Neha Choudhary, Brian O. Patrick
Publikováno v:
Inorganic Chemistry. 60:12186-12196
A new versatile chelating ligand for intermediate size and softness radiometals [64Cu]Cu2+ and [111In]In3+, H2pyhox, was synthesized by introducing pyridine as a new donor moiety to complement 8-hydroxyquinoline on an ethylenediamine backbone. The co