Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Holger Spiegel"'
Autor:
Frederick A. Saul, Brigitte Vulliez-Le Normand, Alexander Boes, Holger Spiegel, Clemens H.M. Kocken, Bart W. Faber, Graham A. Bentley
Publikováno v:
Journal of Structural Biology: X, Vol 10, Iss , Pp 100110- (2024)
Apical Membrane Antigen 1 (AMA1) plays a vital role in the invasion of the host erythrocyte by the malaria parasite, Plasmodium. It is thus an important target for vaccine and anti-malaria therapeutic strategies that block the invasion process. AMA1,
Externí odkaz:
https://doaj.org/article/e07f3fe089b443709f003b70b7311b82
Autor:
Ann-Katrin Beuel, Natalia Jablonka, Julia Heesel, Kevin Severin, Holger Spiegel, Stefan Rasche
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Plant secondary metabolites are widely used in the food, cosmetic and pharmaceutical industries. They can be extracted from sterile grown plant cell suspension cultures, but yields and quality strongly depend on the cultivation environment,
Externí odkaz:
https://doaj.org/article/9c13c3099c8a4a458a0878ffe37c0711
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Recombinant expression using Agrobacterium-mediated transient transformation (ATT) of plants has developed into a robust and versatile method to rapidly produce proteins. The capability of plants to efficiently synthesize even homo- and hetero-multim
Externí odkaz:
https://doaj.org/article/c6dd18d3fbd946fbb51517433caaebd4
Autor:
Melanie Seidel-Greven, Otchere Addai-Mensah, Holger Spiegel, Gwladys Nina Chiegoua Dipah, Stefan Schmitz, Gudrun Breuer, Margaret Frempong, Andreas Reimann, Torsten Klockenbring, Rainer Fischer, Stefan Barth, Rolf Fendel
Publikováno v:
Malaria Journal, Vol 20, Iss 1, Pp 1-20 (2021)
Abstract Background Plasmodium falciparum, the parasite causing malaria, affects populations in many endemic countries threatening mainly individuals with low malaria immunity, especially children. Despite the approval of the first malaria vaccine Mo
Externí odkaz:
https://doaj.org/article/4ef67ba7a0174ef2bfb421a7ccc904ff
Autor:
Jan Pietschmann, Nadja Voepel, Leonie Voß, Stefan Rasche, Max Schubert, Michael Kleines, Hans-Joachim Krause, Tamlyn M. Shaw, Holger Spiegel, Florian Schroeper
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
A novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged in China in December 2019, causing an ongoing, rapidly spreading global pandemic. Worldwide, vaccination is now expected to provide containment of the novel virus, resulting
Externí odkaz:
https://doaj.org/article/69e7f4ac6d8e4ac594589303623202aa
Publikováno v:
Frontiers in Plant Science, Vol 10 (2019)
Over the last three decades, the expression of recombinant proteins in plants and plant cells has been promoted as an alternative cost-effective production platform. However, the market is still dominated by prokaryotic and mammalian expression syste
Externí odkaz:
https://doaj.org/article/3cf899935a184c7e8e1bbf4d5eafeda2
Autor:
Sherene Swee Yin Lim, Kek Heng Chua, Greta Nölke, Holger Spiegel, Wai Leong Goh, Sek Chuen Chow, Boon Pin Kee, Rainer Fischer, Stefan Schillberg, Rofina Yasmin Othman
Publikováno v:
PeerJ, Vol 6, p e5780 (2018)
The parasite Toxoplasma gondii causes an opportunistic infection, that is, particularly severe in immunocompromised patients, infants, and neonates. Current antiparasitic drugs are teratogenic and cause hypersensitivity-based toxic side effects espec
Externí odkaz:
https://doaj.org/article/59a0c71a416f41cfab0d04d95d94b08a
Publikováno v:
Foods, Vol 9, Iss 12, p 1773 (2020)
The misuse of antibiotics as well as incorrect dosage or insufficient time for detoxification can result in the presence of pharmacologically active molecules in fresh milk. Hence, in many countries, commercially available milk has to be tested with
Externí odkaz:
https://doaj.org/article/44de418c69354cf5b55616462288e80d
Publikováno v:
Toxins, Vol 12, Iss 5, p 337 (2020)
Food and crop contaminations with mycotoxins are a severe health risk for consumers and cause high economic losses worldwide. Currently, different chromatographic- and immuno-based methods are used to detect mycotoxins within different sample matrice
Externí odkaz:
https://doaj.org/article/da2ca4c95e794780b53e34f6e4e7faf5
Autor:
Holger Spiegel, Alexander Boes, Rolf Fendel, Andreas Reimann, Stefan Schillberg, Rainer Fischer
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
The blood-stage malaria vaccine candidate Plasmodium falciparum apical membrane antigen 1 (PfAMA1) can induce strong parasite growth-inhibitory antibody responses in animals but has not achieved the anticipated efficacy in clinical trials. Possible e
Externí odkaz:
https://doaj.org/article/a3463a0767bf47dea3fd5b11a0d6a04e