Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Holger P. Behrsing"'
Autor:
Jacqueline Miller-Holt, Holger P. Behrsing, Amy J. Clippinger, Carole Hirn, Todd J. Stedeford, Andreas O. Stucki
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
Regulatory frameworks on tobacco and other nicotine-containing products (TNCP) continue to evolve as novel products emerge, including electronic nicotine delivery systems (e.g., electronic cigarettes or vaping products), heated tobacco products, or c
Externí odkaz:
https://doaj.org/article/9b05286bedab4fa19a357623477dbd22
Autor:
Méry Marimoutou, Vivek Patel, Jae Hun Kim, Niccole Schaible, Jose Alvarez, Joseph Hughes, McKenzie Obermok, Carlos Iván Rodríguez, Thomas Kallarakal, Béla Suki, Khalid Amin, Ramaswamy Krishnan, Holger Peter Behrsing
Publikováno v:
Toxics, Vol 12, Iss 9, p 637 (2024)
Human precision-cut lung slices (hPCLS) prepared from fibrotic lungs recapitulate the pathophysiological hallmarks of fibrosis. These hallmark features can also be induced by treating non-fibrotic hPCLS with a fibrotic cocktail (FC). As a result, the
Externí odkaz:
https://doaj.org/article/b53e0cdbd46b4b568dee45843db8709d
Autor:
Holger P. Behrsing, Adam Wahab, Lindsey Ukishima, Chad Grodi, Stefan Frentzel, Stephanie Johne, Shinkichi Ishikawa, Shigeaki Ito, Roman Wieczorek, Jessica Budde, Brian M. Keyser, Linsey E. Haswell, David Thorne, Emma Bishop, Damien Breheny, Xuefei Cao, Qin Qin, Vivek Patel
Publikováno v:
Alternatives to Laboratory Animals. 50:293-309
The use of reconstituted human airway (RHuA) epithelial tissues to assess functional endpoints is highly relevant in respiratory toxicology, but standardised methods are lacking. In June 2015, the Institute for In Vitro Sciences (IIVS) held a technic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96b714f002a830265eb184ea01e0518e
https://doi.org/10.1177/02611929221114383
https://doi.org/10.1177/02611929221114383
Autor:
Jae Hun Kim, Niccole Schaible, Joseph K. Hall, Erzsébet Bartolák-Suki, Yuqing Deng, Jacob Herrmann, Adam Sonnenberg, Holger P. Behrsing, Kenneth R. Lutchen, Ramaswamy Krishnan, Béla Suki
Publikováno v:
Science Advances. 9
Emphysema is a debilitating disease that remodels the lung leading to reduced tissue stiffness. Thus, understanding emphysema progression requires assessing lung stiffness at both the tissue and alveolar scales. Here, we introduce an approach to dete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::714bab7e4aee8d88a4e795f14662fd1d
https://doi.org/10.1126/sciadv.adf2535
https://doi.org/10.1126/sciadv.adf2535
Autor:
Vivek S Patel, Khalid Amin, Adam Wahab, Méry Marimoutou, Lindsey Ukishima, Jose Alvarez, Kelley Battle, Andreas O Stucki, Amy J Clippinger, Holger P Behrsing
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology.
Human precision-cut lung slices (hPCLS), considered a highly relevant ex vivo model of the lung, offer native architecture and cells of the lung tissue including respiratory parenchyma, small airways, and immune competent cells. However, the irregula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87cd191d0d5907f96b93a445e4249254
https://pubmed.ncbi.nlm.nih.gov/36617185
https://pubmed.ncbi.nlm.nih.gov/36617185
Autor:
Facundo M. Cutuli, Holger P. Behrsing
Publikováno v:
Advances in Toxicology. 2014:1-12
The investigational anticancer agent batracylin (BAT; 8-aminoisoindolo [1,2-b]quinazolin-10(12H)-one; NSC320846) causes γ-H2AX foci development in exposed tumor cells and has demonstrated activity against solid tumors and adriamycin-resistant leukem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fc0b8b11990d9a7576090540896e93b
https://doi.org/10.1155/2014/283749
https://doi.org/10.1155/2014/283749
Autor:
Joel M. Reid, Mary J. Kuffel, Joseph M. Covey, Holger P. Behrsing, Chad A. Walden, Sarah A. Buhrow, Matthew M. Ames
Publikováno v:
Journal of drug metabolismtoxicology. 7(2)
Background: Batracylin is a heterocyclic arylamine topoisomerase inhibitor with preclinical anticancer activity. Marked species differences in sensitivity to the toxicity of batracylin were observed and attributed to differential formation of N-acety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db33d831c7d3d1d784eddeaad0c50100
https://pubmed.ncbi.nlm.nih.gov/27441096
https://pubmed.ncbi.nlm.nih.gov/27441096
Autor:
Holger P. Behrsing, John Hamre, Sandy Eldridge, Myrtle Davis, Facundo M. Cutuli, Liang Guo, Jodie Mussio
Publikováno v:
Toxicological Sciences. :kfw254
Chemotherapy-induced peripheral neuropathy (CIPN) is a major, dose-limiting adverse effect experienced by cancer patients. Advancements in mechanism-based risk mitigation and effective treatments for CIPN can be aided by suitable in vitro assays. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab8b0866186dd51fc407fe7ad910adcb
https://doi.org/10.1093/toxsci/kfw254
https://doi.org/10.1093/toxsci/kfw254
Autor:
Chad A. Walden, Joseph M. Covey, Mary J. Kuffel, Holger P. Behrsing, Myrtle Davis Millin, Sarah A. Buhrow, Joel M. Reid, Matthew M. Ames
Publikováno v:
Cancer Research. 71:1303-1303
Batracylin (NSC 320846, BAT) is a heterocyclic arylamine and topoisomerase II inhibitor that was shown to be active in several murine tumor models. Pharmacology and toxicology studies demonstrated marked species differences in sensitivity to the toxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac118c22e6fabac5ce0c44efba79a74a
https://doi.org/10.1158/1538-7445.am2011-1303
https://doi.org/10.1158/1538-7445.am2011-1303
Autor:
Brendon M. McGuire, Jaeho Jung, Andy Do, Rik Bundey, Brad Gray, Dong-Jin Suh, Delai Zhao, Robert G. Gish, Sung-Soo Park, Jennifer Tam, Holger P. Behrsing
Publikováno v:
ASAIO Journal. 52:10A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe47880f2c3d9881131a9e93a836adf8
https://doi.org/10.1097/00002480-200603000-00057
https://doi.org/10.1097/00002480-200603000-00057