Výsledky vyhledávání - "Holger Neecke"

Checkpoint Proteins Influence Telomeric Silencing and Length Maintenance in Budding Yeast

Autor: Giovanna Lucchini, Maria Pia Longhese, Holger Neecke, Vera Paciotti

Publikováno v: Scopus-Elsevier

A complex network of surveillance mechanisms, called checkpoints, interrupts cell cycle progression when damage to the genome is detected or when cells fail to complete DNA replication, thus ensuring genetic integrity. In budding yeast, components of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b0d3eee3d8caff3c2c918c15dd29be1
https://doi.org/10.1093/genetics/155.4.1577

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Cell cycle progression in the presence of irreparable DNA damage is controlled by a Mec1- and Rad53-dependent checkpoint in budding yeast

Autor: Holger Neecke, Giovanna Lucchini, Maria Pia Longhese

Publikováno v: The EMBO Journal. 18:4485-4497

We studied the response of nucleotide excision repair (NER)-defective rad14Delta cells to UV irradiation in G(1) followed by release into the cell cycle. Only a subset of checkpoint proteins appears to mediate cell cycle arrest and regulate the timel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::958f1d8a859e46ae4b386a12ff2f691b
https://doi.org/10.1093/emboj/18.16.4485

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Mutations in the Gene Encoding the 34 kDa Subunit of Yeast Replication Protein A Cause Defective S Phase Progression

Autor: Paolo Plevani, Corrado Santocanale, Holger Neecke, Giovanna Lucchini, Maria Pia Longhese

Publikováno v: Journal of Molecular Biology. 254:595-607

The in vivo function of the 34 kDa subunit of yeast replication protein A (RPA), encoded by the RFA2 gene, has been studied by analyzing the effect of Rpa34 depletion and by producing and characterizing rfa2 temperature-sensitive mutants. We show tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf0d24cf23fe6e897ab020a0e32b6649
https://doi.org/10.1006/jmbi.1995.0641

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The set1Delta mutation unveils a novel signaling pathway relayed by the Rad53-dependent hyperphosphorylation of replication protein A that leads to transcriptional activation of repair genes

Autor: Yves Corda, Eric Gilson, Maria Pia Longhese, Vera Schramke, Vincent Géli, Giovanna Lucchini, Vanessa Brevet, Holger Neecke

SET domain proteins are present in chromosomal proteins involved in epigenetic control of transcription. The yeast SET domain protein Set1p regulates chromatin structure, DNA repair, and telomeric functions. We investigated the mechanism by which the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::606bf8c9a9e0f92d8c3ee8b5073c438f
http://hdl.handle.net/10281/1828

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The 70 kDa subunit of replication protein A is required for the G1/S and intra-S DNA damage checkpoints in budding yeast

Autor: Paolo Plevani, Giovanna Lucchini, Maria Pia Longhese, Holger Neecke, Vera Paciotti

Publikováno v: Scopus-Elsevier

The rfa1-M2 and rfa1-M4 Saccharomyces cerevisiae mutants, which are altered in the 70 kDa subunit of replication protein A (RPA) and sensitive to UV and methyl methane sulfonate (MMS), have been analyzed for possible checkpoint defects. The G1/S and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e638b291a4711f68ff16b701ac6237d3
http://www.scopus.com/inward/record.url?eid=2-s2.0-0029791693&partnerID=MN8TOARS

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