Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Holger Moroder"'
Publikováno v:
Nucleic Acids Research
The 3′-peptidyl-tRNA conjugates that possess a hydrolysis-resistant ribose-3′-amide linkage instead of the natural ester linkage would represent valuable substrates for ribosomal studies. Up to date, access to these derivatives is severely limite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a75195634a046501b26bbc43d3a2953
https://doi.org/10.1093/nar/gkq508
https://doi.org/10.1093/nar/gkq508
Autor:
Krista Trappl, Ronald Micura, Katja Fauster, Jessica Steger, Holger Moroder, Dagmar Graber, Viter Márquez, Norbert Polacek, Daniel N. Wilson
Publikováno v:
Angewandte Chemie International Edition. 48:4056-4060
Translation of specific small peptides on the ribosome can confer resistance to macrolide antibiotics. To reveal the molecular details of this and related phenomena, stable RNA-peptide conjugates that mimic peptidyl-tRNA would be desirable, especiall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b780143bd1ef46bfe8da35308c4bd837
https://doi.org/10.1002/anie.200900939
https://doi.org/10.1002/anie.200900939
Publikováno v:
Nucleic Acids Research
Site-specifically modified 2’-methylseleno RNA represents a valuable derivative for phasing of X-ray crystallographic data. Several successful applications in three-dimensional structure determination of nucleic acids, such as the Diels–Alder rib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db4557ebd8d361d70c775a59b637ced5
http://europepmc.org/articles/PMC2241898
http://europepmc.org/articles/PMC2241898
Publikováno v:
Journal of the American Chemical Society. 128:9909-9918
We have recently introduced a basic concept for the combined chemical and enzymatic preparation of site-specifically modified 2'-methylseleno RNAs which represent useful derivatives for phasing of X-ray crystallographic data during their three-dimens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::988fecf7345b3300096c169d30b1b0ef
https://doi.org/10.1021/ja0621400
https://doi.org/10.1021/ja0621400
Autor:
Dagmar, Graber, Krista, Trappl, Jessica, Steger, Anna-Skrollan, Geiermann, Lukas, Rigger, Holger, Moroder, Norbert, Polacek, Ronald, Micura
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 848
We present a protocol for the reliable synthesis of non-hydrolyzable 3'-peptidyl-tRNAs that contain all the respective genuine nucleoside modifications. The approach is exemplified by tRNA(Val)-3'-NH-VFLVM-NH(2) and relies on commercially available E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::144fe0eb22741d1814c39eb84d2484c0
https://pubmed.ncbi.nlm.nih.gov/22315071
https://pubmed.ncbi.nlm.nih.gov/22315071
Autor:
Dagmar Graber, Lukas Rigger, Norbert Polacek, Jessica Steger, Krista Trappl, Ronald Micura, Anna-Skrollan Geiermann, Holger Moroder
Publikováno v:
Methods in Molecular Biology ISBN: 9781617795442
We present a protocol for the reliable synthesis of non-hydrolyzable 3'-peptidyl-tRNAs that contain all the respective genuine nucleoside modifications. The approach is exemplified by tRNA(Val)-3'-NH-VFLVM-NH(2) and relies on commercially available E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d01c2b01f439510ad66122fd14224f3
https://doi.org/10.1007/978-1-61779-545-9_13
https://doi.org/10.1007/978-1-61779-545-9_13
Autor:
Jessica Steger, Dagmar Graber, Ronald Micura, Michaela Aigner, Holger Moroder, Anna-Skrollan Geiermann
Publikováno v:
Angewandte Chemie (International ed. in English). 49(41)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04afe42c58c3bd8033b5f63dc066daff
https://pubmed.ncbi.nlm.nih.gov/21038451
https://pubmed.ncbi.nlm.nih.gov/21038451
Publikováno v:
Journal of the American Chemical Society. 130(51)
Labeling of RNA with site-specific fluorine atoms has become straightforward in recent years and in particular has become an integrated part of engineered functional RNA with therapeutic potential, e.g. for siRNA technologies. Here, we demonstrate th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6204b182827e32001d34f3732ca715ad
https://pubmed.ncbi.nlm.nih.gov/19053191
https://pubmed.ncbi.nlm.nih.gov/19053191
Autor:
Christoph Kreutz, Holger Moroder, Kathrin Lang, Claudia Höbartner, Ronald Micura, Barbara Puffer, Renate Rieder
Publikováno v:
Current Protocols in Nucleic Acid Chemistry
The derivatization of nucleic acids with selenium is a useful approach to facilitate phase determination during three-dimensional structural analysis by X-ray crystallography. This unit describes (1) the synthesis and characterization of 2′-deoxy-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f6e3c22f1201cc51c7f1ac8daf4a011
https://pubmed.ncbi.nlm.nih.gov/18428963
https://pubmed.ncbi.nlm.nih.gov/18428963
Publikováno v:
Nucleic Acids Symposium Series. 52:315-316
Site-specifically modified 2'-methylseleno RNA represents a valuable derivative for phasing of X-ray crystallographic data. Several successful applications in three-dimensional structure determination of nucleic acids, such as the Diels-Alder ribozym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a52d36c0ad1ba817a75f84792c60184
https://doi.org/10.1093/nass/nrn159
https://doi.org/10.1093/nass/nrn159