Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Holger Meixner"'
Autor:
Florian Krach, Judith Stemick, Tom Boerstler, Alexander Weiss, Ioannis Lingos, Stephanie Reischl, Holger Meixner, Sonja Ploetz, Michaela Farrell, Ute Hehr, Zacharias Kohl, Beate Winner, Juergen Winkler
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Krach et al. dissect the molecular mechanism of the alternative splicing modulator Branaplam in Huntington’s disease. They show that the drug lowers mutant HTT protein levels and ameliorates alternative splicing pathology in an iPSC disease model.
Externí odkaz:
https://doaj.org/article/de498125578b4e53ac4080e1dc3242e6
Autor:
Alexandra Cosma-Grigorov, Holger Meixner, Anne Mrochen, Stefan Wirtz, Jürgen Winkler, Franz Marxreiter
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Altered gut microbiota may trigger or accelerate alpha-synuclein aggregation in the enteric nervous system in Parkinson's disease (PD). While several previous studies observed gut microbiota alterations in PD, findings like diversity indices, and alt
Externí odkaz:
https://doaj.org/article/460654319b9d4141aa37332fe9cc3ee0
Autor:
Jürgen Winkler, Frederik Bode, Christian P. Müller, Stephan von Hörsten, Bjoern M. Eskofier, Nicolas Casadei, Jochen Klucken, Liubov S. Kalinichenko, Olaf Riess, Frédéric Chevessier, Stefanie Menges, Ivanna K. Timotius, Holger Meixner, Wei Xiang, Fabio Canneva, Rolf Schröder, Georgia Minakaki
Publikováno v:
Behavioural brain research. 363
Gait and postural control dysfunction are prototypical symptoms compromising quality of life for patients with Parkinson’s disease (PD). Hallmarks of cellular pathology are dopaminergic degeneration and accumulation of the cytosolic protein alpha-s
Autor:
H. Warnecke, W. Rees, M. Kowalski, Holger Meixner, R. Grove, J.W. Konturek, N. Franz, J. Thale, Eckhart G. Hahn, Stanislaw J. Konturek, Piotr Pieniazek, T. Scheffold, M. Brunec, P C Konturek
Publikováno v:
Digestive and Liver Disease. 34:398-402
Background. Chronic infections have been proposed to play a role in the aetiology or progression of atherosclerotic plaques. Increased risk of coronary artery disease has been suggested in patients seropositive for Helicobacter pylori. Aim. To analys
Autor:
P C Konturek, Holger Meixner, Jolanta Jaworek, Eckhart G. Hahn, A Maniatoglou, J Bonior, S J Konturek
Publikováno v:
Digestion. 65:149-160
Background: Leptin is a pleiotropic hormone that is involved in the regulation of food intake and body weight. Recent findings demonstrated that leptin receptors are present in the pancreas but the involvement of leptin in pancreatitis remains unknow
Autor:
Wei, Xiang, Stefanie, Menges, Johannes Cm, Schlachetzki, Holger, Meixner, Anna-Carin, Hoffmann, Ursula, Schlötzer-Schrehardt, Cord-Michael, Becker, Jürgen, Winkler, Jochen, Klucken
Publikováno v:
Molecular Neurodegeneration
Background Aggregation and aggregation-mediated formation of toxic alpha synuclein (aSyn) species have been linked to the pathogenesis of sporadic and monogenic Parkinson’s disease (PD). A novel H50Q mutation of aSyn, resulting in the substitution
Autor:
Philipp Spitzer, Anne-Maria Poehler, Holger Meixner, J. Winkler, Oldriska Chutna, Edward Rockenstein, Verena E.L. May, Jochen Klucken, Tiago F. Outeiro, Wei Xiang, Eliezer Masliah
SNCA/α-synuclein aggregation plays a crucial role in synucleinopathies such as Parkinson disease and dementia with Lewy bodies. Aggregating and nonaggregating SNCA species are degraded by the autophagy-lysosomal pathway (ALP). Previously, we have sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::221eb1062fc7630513990e5ee1c28780
Autor:
K. Marlicz, W. Bielanski, S J Konturek, J Stachura, P C Konturek, Teresa Starzyńska, Holger Meixner, Elżbieta Karczewska, Eckhart G. Hahn, Zora Sulekova
Publikováno v:
Alimentary Pharmacology & Therapeutics. 15:989-999
Background: Gastric cancer is one of the most frequent neoplasms and a leading cause of the death world-wide. In recent years, epidemiological and animal studies demonstrated a link between gastric cancer and chronic infection with H. pylori. The exa
Autor:
Stanislaw J. Konturek, Holger Meixner, Tomasz Brzozowski, Jerzy Stachura, Peter C. Konturek, Igor Alexander Harsch, Danuta Drozdowicz, Slawomir Kwiecien, Eckhart G. Hahn
Helicobacter pylori and nonsteroidal anti-inflammatory drugs (NSAIDs) are major pathogenic factors in peptic ulcer disease but whether these two factors exert synergistic or antagonistic effects on ulcer healing has been a subject of controversy. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdc98d00f318aa0546c52f5436688d0a
https://ruj.uj.edu.pl/xmlui/handle/item/265291
https://ruj.uj.edu.pl/xmlui/handle/item/265291
Autor:
Tomasz Brzozowski, Stanislaw J. Konturek, Aleksandra Duda, Zora Sulekova, Peter C. Konturek, Eckhart G. Hahn, Iwona Brzozowska, Holger Meixner
Leptin was shown to exhibit similar to cholecystokinin (CCK) cytoprotective activity against acute gastric lesions, but its role in ulcer healing has not been examined. The aims of this study were: (1) to compare the effects of exogenous leptin to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b79ab11ab3b4c090d1d04463a642b43f
https://ruj.uj.edu.pl/xmlui/handle/item/265280
https://ruj.uj.edu.pl/xmlui/handle/item/265280