Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Holger M Reichardt"'
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190846 (2018)
Inflammatory bowel disease (IBD) is a highly prevalent intestinal disorder for which no cure exists. Currently, the standard first-line treatment of IBD consists of systemic glucocorticoid (GC) application, even though therapy can be complicated by u
Externí odkaz:
https://doaj.org/article/d047674287c74355b741058641ef9e1b
Autor:
Elena Montes-Cobos, Xiao Li, Henrike J Fischer, André Sasse, Sebastian Kügler, Michael Didié, Karl Toischer, Martin Fassnacht, Ralf Dressel, Holger M Reichardt
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0143954 (2015)
Mineralocorticoid receptor (MR) inactivation in mice results in early postnatal lethality. Therefore we generated mice in which MR expression can be silenced during adulthood by administration of doxycycline (Dox). Using a lentiviral approach, we obt
Externí odkaz:
https://doaj.org/article/24b56fc18aaa4e4da2c311270cbb4f41
Autor:
Holger Budde, Susanne Kolb, Laura Salinas Tejedor, Gerald Wulf, Holger M Reichardt, Joachim Riggert, Tobias J Legler
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105896 (2014)
Graft-versus-host disease (GvHD) is a major challenge after hematopoietic stem cell transplantation but treatment options for patients are still limited. In many cases first-line treatment with glucocorticoids is not successful. Among second-line the
Externí odkaz:
https://doaj.org/article/2e238de72c054bf5b64b5bef5c409d99
Autor:
Simone König, Frauke Nitzki, Anja Uhmann, Kai Dittmann, Jennifer Theiss-Suennemann, Markus Herrmann, Holger M Reichardt, Reto Schwendener, Tobias Pukrop, Walter Schulz-Schaeffer, Heidi Hahn
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93555 (2014)
Basal cell carcinoma (BCC) belongs to the group of non-melanoma skin tumors and is the most common tumor in the western world. BCC arises due to mutations in the tumor suppressor gene Patched1 (Ptch). Analysis of the conditional Ptch knockout mouse m
Externí odkaz:
https://doaj.org/article/e330aa80843a4dd0bbf5f0d15e43be40
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61034 (2013)
Hedgehog (Hh) signaling modulates T cell development and function but its exact role remains a matter of debate. To further address this issue we made use of conditional knock-out mice in which the Hh receptor Patched1 (Ptch) is inactivated in the T
Externí odkaz:
https://doaj.org/article/7c5d810cb55a4acabbf557094bcba62f
Autor:
Silviu Sbiera, Thomas Dexneit, Sybille D Reichardt, Kai D Michel, Jens van den Brandt, Sebastian Schmull, Luitgard Kraus, Melanie Beyer, Robert Mlynski, Sebastian Wortmann, Bruno Allolio, Holger M Reichardt, Martin Fassnacht
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24345 (2011)
BackgroundPre- and early clinical studies on patients with autoimmune diseases suggested that induction of regulatory T(T(reg)) cells may contribute to the immunosuppressive effects of glucocorticoids (GCs).ObjectiveWe readdressed the influence of GC
Externí odkaz:
https://doaj.org/article/8dfa2468c3014442803551625f2080a3
Autor:
Simone Wüst, Denise Tischner, Michael John, Jan P Tuckermann, Christiane Menzfeld, Uwe-Karsten Hanisch, Jens van den Brandt, Fred Lühder, Holger M Reichardt
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e8202 (2009)
BACKGROUND: Dissociating glucocorticoid receptor (GR) ligands hold great promise for treating inflammatory disorders since it is assumed that they exert beneficial activities mediated by transrepression but avoid adverse effects of GR action requirin
Externí odkaz:
https://doaj.org/article/9131bf4fc0fc475bbecdc5ffc8b0ca31
Autor:
Gesa J. Albers, Agathe Amouret, Katrin Ciupka, Elena Montes-Cobos, Claus Feldmann, Holger M. Reichardt
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 23, p 16843 (2023)
Glucocorticoids (GCs) are widely used to treat inflammatory disorders such as acute lung injury (ALI). Here, we explored inorganic–organic hybrid nanoparticles (IOH-NPs) as a new delivery vehicle for GCs in a mouse model of ALI. Betamethasone (BMZ)
Externí odkaz:
https://doaj.org/article/40c63199529545569dcd67d59fde7494
Autor:
Chiara Muzzi, Norika Watanabe, Eric Twomey, Garrit K. Meers, Holger M. Reichardt, Hanibal Bohnenberger, Sybille D. Reichardt
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 5, Pp 1505-1518 (2021)
Background & Aims: Inflammatory bowel disease is commonly treated by administration of glucocorticoids. While the importance of intestinal epithelial cells for the pathogenesis of this disorder is widely accepted, their role as target cells for gluco
Externí odkaz:
https://doaj.org/article/fa90ccd78aaf40c0a2a08e384bdb4121
Autor:
Leonie Meyer-Heemsoth, Katja Mitschke, Jasmina Bier, Konstantin Schütz, Andreas Villunger, Tobias J. Legler, Martin S. Weber, Fred Lühder, Holger M. Reichardt
Publikováno v:
Cells, Vol 12, Iss 3, p 450 (2023)
Glucocorticoids (GCs) are used to treat inflammatory disorders such as multiple sclerosis (MS) by exerting prominent activities in T cells including apoptosis induction and suppression of cytokine production. However, little is known about their impa
Externí odkaz:
https://doaj.org/article/7aa68e66f5924d57a5e3dda753c2a6fd