Zobrazeno 1 - 10
of 162
pro vyhledávání: '"Holger M, Reichardt"'
Autor:
Chiara Muzzi, Norika Watanabe, Eric Twomey, Garrit K. Meers, Holger M. Reichardt, Hanibal Bohnenberger, Sybille D. Reichardt
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 5, Pp 1505-1518 (2021)
Background & Aims: Inflammatory bowel disease is commonly treated by administration of glucocorticoids. While the importance of intestinal epithelial cells for the pathogenesis of this disorder is widely accepted, their role as target cells for gluco
Externí odkaz:
https://doaj.org/article/fa90ccd78aaf40c0a2a08e384bdb4121
Autor:
Leonie Meyer-Heemsoth, Katja Mitschke, Jasmina Bier, Konstantin Schütz, Andreas Villunger, Tobias J. Legler, Martin S. Weber, Fred Lühder, Holger M. Reichardt
Publikováno v:
Cells, Vol 12, Iss 3, p 450 (2023)
Glucocorticoids (GCs) are used to treat inflammatory disorders such as multiple sclerosis (MS) by exerting prominent activities in T cells including apoptosis induction and suppression of cytokine production. However, little is known about their impa
Externí odkaz:
https://doaj.org/article/7aa68e66f5924d57a5e3dda753c2a6fd
Autor:
Malte Tiburcy, Alex Markov, Lena K. Kraemer, Peter Christalla, Margret Rave‐Fraenk, Henrike J. Fischer, Holger M. Reichardt, Wolfram‐Hubertus Zimmermann
Publikováno v:
FASEB BioAdvances, Vol 1, Iss 12, Pp 731-746 (2019)
Abstract Satellite cells reside in defined niches and are activated upon skeletal muscle injury to facilitate regeneration. Mechanistic studies of skeletal muscle regeneration are hampered by the inability to faithfully simulate satellite cell biolog
Externí odkaz:
https://doaj.org/article/7b9d3c00f09b42efb6f04603c7aa7345
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Induction of T cell apoptosis constitutes a major mechanism by which therapeutically administered glucocorticoids (GCs) suppress inflammation and associated clinical symptoms, for instance in multiple sclerosis (MS) patients suffering from an acute r
Externí odkaz:
https://doaj.org/article/61f64426410445719c02ef8c2395a8a4
Publikováno v:
Cells, Vol 11, Iss 5, p 885 (2022)
Testicular germ cell cancer (TGCC) is the most common type of cancer in young men. Seminomas account for around half of them and are characterized by a pronounced infiltration of immune cells. So far, the impact of the tumor microenvironment (TME) on
Externí odkaz:
https://doaj.org/article/8eec330a22c14ae9985f7caa0bbf42b5
Autor:
Sybille D. Reichardt, Agathe Amouret, Chiara Muzzi, Sabine Vettorazzi, Jan P. Tuckermann, Fred Lühder, Holger M. Reichardt
Publikováno v:
Cells, Vol 10, Iss 11, p 2921 (2021)
For more than 70 years, glucocorticoids (GCs) have been a powerful and affordable treatment option for inflammatory diseases. However, their benefits do not come without a cost, since GCs also cause side effects. Therefore, strong efforts are being m
Externí odkaz:
https://doaj.org/article/8259bbf6ae884f8d95dec4607745f541
Autor:
Henrike J. Fischer, Tobias L. K. Finck, Hannah L. Pellkofer, Holger M. Reichardt, Fred Lühder
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system (CNS), characterized by the infiltration of mononuclear cells into the CNS and a subsequent inflammation of the brain. Monocytes are implicated in disease pathogenesis not
Externí odkaz:
https://doaj.org/article/4b9922af746f4701a1fd07c9401cb439
Autor:
Lourdes Rocamora-Reverte, Selma Tuzlak, Laura von Raffay, Marcel Tisch, Heidi Fiegl, Mathias Drach, Holger M. Reichardt, Andreas Villunger, Denise Tischner, G. Jan Wiegers
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Activation of the immune system increases systemic adrenal-derived glucocorticoid (GC) levels which downregulate the immune response as part of a negative feedback loop. While CD4+ T cells are essential target cells affected by GC, it is not known wh
Externí odkaz:
https://doaj.org/article/1ff41dd18e2a4e848458c96ff01777d9
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190846 (2018)
Inflammatory bowel disease (IBD) is a highly prevalent intestinal disorder for which no cure exists. Currently, the standard first-line treatment of IBD consists of systemic glucocorticoid (GC) application, even though therapy can be complicated by u
Externí odkaz:
https://doaj.org/article/d047674287c74355b741058641ef9e1b
Autor:
Elena Montes-Cobos, Nils Schweingruber, Xiao Li, Henrike J. Fischer, Holger M. Reichardt, Fred Lühder
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Myeloid cells play an important role in the pathogenesis of multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). Monocytes, macrophages, and microglia can adopt two distinct phenotypes, with M1-polarized cells
Externí odkaz:
https://doaj.org/article/f7706abd0af340008645ad4b0ff4f9e8