Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Holger Luthman"'
Publikováno v:
Epigenetics, Vol 16, Iss 1, Pp 92-105 (2021)
Difficulty in obtaining bone tissue is an obstacle to studying epigenetics to understand gene–environment interactions, and their role in disease pathogenesis. Blood is an obvious alternative and in this proof of principle study, our aim was to sys
Externí odkaz:
https://doaj.org/article/646b6111079d4f66852c3f35f5004317
Autor:
Gaurav Garg, Fiona E. McGuigan, Jitender Kumar, Holger Luthman, Valeriya Lyssenko, Kristina Akesson
Publikováno v:
Bone Reports, Vol 4, Iss C, Pp 23-27 (2016)
Introduction: The gastro-intestinal hormone glucose-dependent insulinotropic polypeptide (GIP) potentiates glucose-induced insulin secretion, with bone anabolic effects through GIP receptor (GIPR) in animal models. We explore its potential in humans
Externí odkaz:
https://doaj.org/article/e18a2753af1443d0ae6e2d7ba5406275
Autor:
Gaurav Garg, Jitender Kumar, Fiona E McGuigan, Martin Ridderstråle, Paul Gerdhem, Holger Luthman, Kristina Åkesson
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88565 (2014)
Osteoporosis is characterized by reduced bone mineral density (BMD) and increased fracture risk. Fat mass is a determinant of bone strength and both phenotypes have a strong genetic component. In this study, we examined the association between obesit
Externí odkaz:
https://doaj.org/article/0e094f5e93d34c0a931fbd8df2f3be67
Autor:
Samina Asad, Pernilla Nikamo, Alexandra Gyllenberg, Hedvig Bennet, Ola Hansson, Nils Wierup, Diabetes Incidence in Sweden Study Group, Annelie Carlsson, Gun Forsander, Sten-Anders Ivarsson, Helena Larsson, Åke Lernmark, Bengt Lindblad, Johnny Ludvigsson, Claude Marcus, Kjersti S Rønningen, Jan Nerup, Flemming Pociot, Holger Luthman, Malin Fex, Ingrid Kockum
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e35439 (2012)
We have previously performed a genome-wide linkage study in Scandinavian Type 1 diabetes (T1D) families. In the Swedish families, we detected suggestive linkage (LOD≤2.2) to the chromosome 5p13-q13 region. The aim of our study was to investigate th
Externí odkaz:
https://doaj.org/article/d020702585b743e7abaaa11f9d37d59c
Autor:
Sofia Lagerholm, Hee-Bok Park, Holger Luthman, Marc Grynpas, Fiona McGuigan, Maria Swanberg, Kristina Åkesson
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22462 (2011)
Susceptibility to osteoporotic fracture is influenced by genetic factors that can be dissected by whole-genome linkage analysis in experimental animal crosses. The aim of this study was to characterize quantitative trait loci (QTLs) for biomechanical
Externí odkaz:
https://doaj.org/article/f9d748cd12694dc48b58c4ebaa6d1047
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e8148 (2009)
The proper function of mammalian mitochondria necessitates a coordinated expression of both nuclear and mitochondrial genes, most likely due to the co-evolution of nuclear and mitochondrial genomes. The non-protein coding regions of mitochondrial DNA
Externí odkaz:
https://doaj.org/article/376374a61c04465ba1d4d0e3697f0ef5
Publikováno v:
Epigenetics
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Difficulty in obtaining bone tissue is an obstacle to studying epigenetics to understand gene–environment interactions, and their role in disease pathogenesis. Blood is an obvious alternative and in this proof of principle study, our aim was to sys
Publikováno v:
Osteoporosis International; 26(2), pp 727-735 (2015)
Summary This longitudinal study investigates the association between C-reactive protein (CRP), osteoporosis, fractures, and mortality in 1044 elderly women. CRP was not an indi- cator for low bone mineral density (BMD), bone loss, or fracture in elde
Publikováno v:
Bone Abstracts.
Autor:
Christina Jern, Ulf Kristoffersson, Arne Lindgren, Holger Luthman, Katarina Jood, Bo Hedblad, Gunnar Andsberg, Peter Höglund, Marketa Sjögren, Bo Norrving, Gunnar Engström, J. Gustav Smith, Sandra Olsson, Olle Melander, Håkan Lövkvist, Hossein Delavaran
Publikováno v:
European Journal of Human Genetics. 20:783-789
Previous reports have shown ambiguous findings regarding the possible associations between ischaemic stroke (IS) and single nucleotide polymorphisms (SNPs) in the phosphodiesterase 4D (PDE4D) gene region. The SNP rs12188950 (or SNP45) has often been