Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Holger Kohlhammer"'
Autor:
Masao Nakagawa, James D. Phelan, Sigrid Dubois, Patrick L. Green, Louis M. Staudt, Michiyuki Maeda, George E. Wright, Wenming Xiao, Dan E. Webster, Holger Kohlhammer, Yandan Yang, Hee Min Yoo, Hong Zhao, Weihong Xu, Da-Wei Huang, Bonita R. Bryant, Xin Yu, Takashi Ishio, Joji Shimono, Meili Zhang, Yibin Yang, Michele Ceribelli, Emmanuel Bachy, Michael N. Petrus, Thomas A. Waldmann, Arthur L. Shaffer, John Powell
Publikováno v:
Cancer Cell
Summary Adult T cell leukemia/lymphoma (ATLL) is a frequently incurable disease associated with the human lymphotropic virus type I (HTLV-I). RNAi screening of ATLL lines revealed that their proliferation depends on BATF3 and IRF4, which cooperativel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a42fd22a0ab5adccddb7616169c3476
https://pubmed.ncbi.nlm.nih.gov/30057145
https://pubmed.ncbi.nlm.nih.gov/30057145
Autor:
Masao Nakagawa, James D. Phelan, Wenming Xiao, Holger Kohlhammer, Dan E. Webster, Daniel J. Hodson, Thomas A. Waldmann, Louis M. Staudt, Roland Schmitz, George E. Wright, Lixin Rui, Arthur L. Shaffer, Yandan Yang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 113(14)
The requirement for the B-cell transcription factor OCT2 (octamer-binding protein 2, encoded by Pou2f2) in germinal center B cells has proved controversial. Here, we report that germinal center B cells are formed normally after depletion of OCT2 in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f39905178da85f690049c1517fe40ab4
https://pubmed.ncbi.nlm.nih.gov/26993806
https://pubmed.ncbi.nlm.nih.gov/26993806
Autor:
Bum Kyu Lee, Arthur L. Shaffer, Vishwanath R. Iyer, George Georgiou, Louis M. Staudt, Wei Deng, Daechan Park, Holger Kohlhammer, Haley O. Tucker, Gregory C. Ippolito, Joseph D. Dekker
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 113(5)
High expression of the forkhead box P1 (FOXP1) transcription factor distinguishes the aggressive activated B cell (ABC) diffuse large B-cell lymphoma (DLBCL) subtype from the better prognosis germinal center B-cell (GCB)-DLBCL subtype and is highly c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97c4b5277acfce8657ec2ad78cd0623c
https://pubmed.ncbi.nlm.nih.gov/26787899
https://pubmed.ncbi.nlm.nih.gov/26787899
Autor:
Lee N. Lawton, Richard A. Young, Yebin Ahn, Holger Kohlhammer, Louis M. Staudt, Alejandro Gutierrez, Jessica Tatarek, Wenxue Ma, Zi Peng Fan, Michelle A. Kelliher, A. Thomas Look, Takaomi Sanda, Catriona Jamieson, M. Inmaculada Barrasa
Publikováno v:
Cancer Cell. 22(2):209-221
SummaryThe oncogenic transcription factor TAL1/SCL is aberrantly expressed in over 40% of cases of human T cell acute lymphoblastic leukemia (T-ALL), emphasizing its importance in the molecular pathogenesis of T-ALL. Here we identify the core transcr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::305a7aac19695f68524f821bdff0cd8c
Autor:
Erlend B. Smeland, Elaine S. Jaffe, Richard I. Fisher, Randy D. Gascoyne, Kian-Huat Lim, Sameer Jhavar, Vu N. Ngo, George E. Wright, Louis M. Staudt, Roland Schmitz, Elias Campo, Holger Kohlhammer, Hans K. Müller-Hermelink, German Ott, Paul B. Romesser, Arthur L. Shaffer, Ryan M. Young, Lisa M. Rimsza, Yandan Yang, Denny D. Weisenburger, John Powell, James R. Cook, Jan Delabie, Wenming Xiao, Wing C. Chan, Joseph M. Connors, Weihong Xu, Raymond R. Tubbs, Andreas Rosenwald, Rita M. Braziel, Hong Zhao
Publikováno v:
Nature. 470:115-119
The activated B-cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL) remains the least curable form of this malignancy despite recent advances in therapy1. Constitutive nuclear factor (NF)-κB and JAK kinase signalling promotes malignant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5204e56c1ceea9a061bd151b28f0abb5
https://doi.org/10.1038/nature09671
https://doi.org/10.1038/nature09671
Autor:
Lisa M. Rimsza, Lloyd T. Lam, Elaine S. Jaffe, Elias Campo, Sandeep S. Dave, Arthur L. Shaffer, N. C. Tolga Emre, Dennis D. Weisenburger, German Ott, Hans Konrad Müller-Hermelink, Randy D. Gascoyne, John Powell, Wing C. Chan, Holger Kohlhammer, George E. Wright, Shannon A. Carty, Jan Delabie, Wenming Xiao, Joseph M. Connors, Georg Lenz, Erlend B. Smeland, Andreas Rosenwald, R. Eric Davis, Richard I. Fisher, Louis M. Staudt
Publikováno v:
Proceedings of the National Academy of Sciences. 105:13520-13525
Gene-expression profiling has been used to define 3 molecular subtypes of diffuse large B-cell lymphoma (DLBCL), termed germinal center B-cell-like (GCB) DLBCL, activated B-cell-like (ABC) DLBCL, and primary mediastinal B-cell lymphoma (PMBL). To inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fae8cd312a8d9121d6cb963284d86508
https://doi.org/10.1073/pnas.0804295105
https://doi.org/10.1073/pnas.0804295105
Autor:
Hartmut Döhner, German Ott, Hans Konrad Müller-Hermelink, Thomas F. E. Barth, Holger Kohlhammer, Peter Lichter, Axel Benner, Stephan Stilgenbauer, Andreas Rosenwald, Jörg Kalla, Doreen Saupe, Dirk Kienle, Sylvia Höller, Peter Möller, Tiemo Katzenberger
Publikováno v:
Journal of Clinical Oncology. 25:2770-2777
Purpose There is evidence for a direct role of quantitative gene expression deregulation in mantle-cell lymphoma (MCL) pathogenesis. Our aim was to investigate gene expression associations with other pathogenic factors and the significance of gene ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fbc7110ce2f63d0e48db875f6286c83
https://doi.org/10.1200/jco.2006.08.7999
https://doi.org/10.1200/jco.2006.08.7999
Autor:
Swen Wessendorf, Carsten Schwaenen, Karlheinz Holzmann, Peter Lichter, Bettina Rau, Bernd Radlwimmer, Hartmut Döhner, Holger Kohlhammer, Hans A. Kestler, Martin Bentz, Alexandra Schwoerer, Thomas M. Gress
Publikováno v:
Cancer Research. 64:4428-4433
Genomic analyses aimed at the detection of high-level DNA amplifications were performed on 13 widely used pancreatic cancer cell lines and 6 pancreatic tumor specimens. For these analyses, array-based comparative genomic hybridization (Matrix-CGH) on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7d1c4eb7df4334e688101213c5efcf6
https://doi.org/10.1158/0008-5472.can-04-0431
https://doi.org/10.1158/0008-5472.can-04-0431
Autor:
Bonita R. Bryant, John Powell, Hee Min Yoo, Hong Zhao, Xin Yu, Michael N. Petrus, Michele Ceribelli, Thomas A. Waldmann, L. M. Staudt, Michiyuki Maeda, Masao Nakagawa, Yibin Yang, Meili Zhang, James D. Phelan, Weihong Xu, George E. Wright, Holger Kohlhammer, Yandan Yang, Da-Wei Huang, Wenming Xiao, Arthur L. Shaffer
Publikováno v:
Blood. 130:731-731
After neonatal HTLV-I infection through breast feeding, approximately 5% of HTLV-I carriers eventually develop Adult T-Cell Leukemia/Lymphoma (ATLL) with a latency of ~50 years, suggesting that acquired genetic and epigenetic changes in cellular gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c731b15424b06332a7ef8be40f65a3d
https://doi.org/10.1182/blood.v130.suppl_1.731.731
https://doi.org/10.1182/blood.v130.suppl_1.731.731
Autor:
Miriam R. Anver, Lidia Hernandez, David D.L. Bowtell, George E. Wright, Christina M. Annunziata, Holger Kohlhammer, Ethan Sagher, Anne M. Noonan, L. Tiffany Reed, Patricia S. Steeg
Publikováno v:
Clinical Cancer Research. 21:POSTER-TECH
Ovarian cancer is a leading cause of cancer death in women, and identification of factors determining clinical outcome is essential to enable pathway-directed therapeutic advances. We recently showed that NF-κB signaling is constitutively active in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::655af89491679c0a41add6859b0ed7c5
https://doi.org/10.1158/1557-3265.ovcasymp14-poster-tech-1102
https://doi.org/10.1158/1557-3265.ovcasymp14-poster-tech-1102