Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Holger Keim"'
1
Management and outcomes of 222 CLL patients (pts) treated with venetoclax (VEN) in the real world
Autor: Anthony R. Mato, Jackie Nielsen, Chadi Nabhan, Andrew J Klink, Jennifer C. Samp, Kaitlin Kennard, James M. Pauff, Brian Meissner, Holger Keim
Publikováno v: Journal of Clinical Oncology. 36:7529-7529
7529Background: VEN is an oral bioavailable BCL-2 inhibitor approved by the FDA in April 2016 for use in CLL. More data are needed to understand real world initiation, management and outcomes of CL...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c1149afbb56952a6ed91042fd58e3356
https://doi.org/10.1200/jco.2018.36.15_suppl.7529
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2
Application of cultured human mast cells (CHMC) for the design and structure-activity relationship of IgE-mediated mast cell activation inhibitors
Autor: Alexander B. Rossi, Hui Li, Donald G. Payan, Jeffrey Clough, Ankush Argade, Somasekhar Bhamidipati, Esteban Masuda, Rajinder Singh, Christina Coquilla, Holger Keim, Catherine Sylvain, Sarkiz D. Issakani, David Carroll
Publikováno v: Bioorganicmedicinal chemistry letters. 25(10)
Here we report the optimization of small molecule inhibitors of human mast cell degranulation via anti-IgE-mediated tryptase release following cross-linking and activation of IgE-loaded FceR1 receptors. The compounds are selective upstream inhibitors
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::484ae22a769e3f3799c8f65e82e22633
https://pubmed.ncbi.nlm.nih.gov/25872982
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3
Design, synthesis of diaminopyrimidine inhibitors targeting IgE- and IgG-mediated activation of Fc receptor signaling
Autor: Somasekhar Bhamidipati, Sarkiz D. Issakani, David Carroll, Donald G. Payan, Vanessa Taylor, Catherine Sylvain, Holger Keim, Rajinder Singh, Hui Li, Jeffrey Clough, Ellen Herlaar, Brian Wong, Sylvia Braselmann, Esteban Masuda, Ankush Argade, Haoran Zhao
Publikováno v: Bioorganicmedicinal chemistry letters. 25(10)
Using cultured human mast cells (CHMC) the optimization of 2,4-diaminopyrimidine compounds leading to 22, R406 is described. Compound 22 is a potent upstream inhibitor of mast cell degranulation and its mechanism of action is via inhibition of Syk ki
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5931dfcb85d77bceba1ed91b4e05a12a
https://pubmed.ncbi.nlm.nih.gov/25891105
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4
Inhibition of EGF-mediated receptor activity and cell proliferation by HK1-ceramide, a stable analog of the ganglioside GM3-lactone
Autor: Lutz F. Tietze, Ulrich Borchers, Wolfgang F. Vogel, Jens Olschimke, Rocco Fortte, Hartmut Halfter, Holger Keim, Frauke Alves
Publikováno v: Glycobiology. 12:517-522
Gangliosides have been described as modulators of growth factor receptor activity and subsequent cellular function. Due to the lower-pH environment found in tumor cells, ganglosides are thought to be formed (at least to some extent) into their lacton
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a1e62049aefe3e73e35baf6c0bd1433
https://doi.org/10.1093/glycob/cwf058
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5
Cytogenetic and fluorescence in situ hybridization testing in veterans with chronic lymphocytic leukemia
Autor: Tatyana Kapustyan, Jodi Walker, Brian C. Sauer, Brian Meissner, Ahmad Halwani, Kelli M Rasmussen, Nicole Lawrence, Zachary Burningham, Clarke Low, Vikas Patil, Holger Keim
Publikováno v: Journal of Clinical Oncology. 35:7526-7526
7526 Background: The presence of deletion 17p (del17), determined by chromosome analysis and/or fluorescence in situ hybridization (FISH), is a strong negative prognostic marker in chronic lymphocytic leukemia (CLL). Prior to the introduction of nove
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::03ff4304a5bdabf89b0421c0a39f7c85
https://doi.org/10.1200/jco.2017.35.15_suppl.7526
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6
Synthesis of a Novel Ether-Bridged GM3-Lactone Analogue as a Target for an Antibody-Based Cancer Therapy
Autor: Holger Keim, Christian O. Janßen, Lutz F. Tietze, Jens Olschimke, Christoph Tappertzhofen
Publikováno v: Chemistry - A European Journal. 6:2801-2808
We describe herein the synthesis of a new analogue of the GM3-lactone containing a cyclic ether moiety. The ether moiety was chosen as a replacement for the regular lactone group since it shows high resemblance with the lactone and is completely stab
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::918b7769561a5368df0fca581b45fa74
https://doi.org/10.1002/1521-3765(20000804)6:15<2801::aid-chem2801>3.0.co
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7
Total Synthesis of HUN-7293
Autor: Berndt Oberhauser, Carolyn A. Foster, Dale L. Boger, Erwin P. Schreiner, Holger Keim
Publikováno v: Journal of the American Chemical Society. 121:6197-6205
The first total synthesis of the cyclic heptadepsipeptide HUN-7293 (1), a potent inhibitor of cell adhesion molecule expression exhibiting anti-inflammatory properties, is detailed. The most effect...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c5aa068b154e315c6b6da2f8b6fcd411
https://doi.org/10.1021/ja990918u
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