Zobrazeno 1 - 10 of 36 pro vyhledávání: '"Holger Kanzler"'
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Optimization, Production, and Characterization of a CpG-Oligonucleotide-Ficoll Conjugate Nanoparticle Adjuvant for Enhanced Immunogenicity of Anthrax Protective Antigen
Autor: John D. Campbell, Holger Kanzler, Carlo Calacsan, Melissa A. Kachura, Bob Milley, Gary Ott, Robert L. Coffman, Radwan Kiwan
Publikováno v: Bioconjugate Chemistry
We have synthesized and characterized a novel phosphorothioate CpG oligodeoxynucleotide (CpG ODN)-Ficoll conjugated nanoparticulate adjuvant, termed DV230-Ficoll. This adjuvant was constructed from an amine-functionalized-Ficoll, a heterobifunctional
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::481d8a99f550a71eef73bfe35ac8fd4a
http://europepmc.org/articles/PMC4873889
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4
A CpG-Ficoll Nanoparticle Adjuvant for Anthrax Protective Antigen Enhances Immunogenicity and Provides Single-Immunization Protection against Inhaled Anthrax in Monkeys
Autor: Holger Kanzler, John D. Campbell, Robert Milley, Atul Sathe, Melissa A. Kachura, Sariah A. Kell, Robert L. Coffman, Brian E. Hall, Carlo Calacsan, Gary Ott, Radwan Kiwan, Colin Hickle
Publikováno v: The Journal of Immunology. 196:284-297
Nanoparticulate delivery systems for vaccine adjuvants, designed to enhance targeting of secondary lymphoid organs and activation of APCs, have shown substantial promise for enhanced immunopotentiation. We investigated the adjuvant activity of synthe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f59d57512806485ab21bd54fc166dc94
https://doi.org/10.4049/jimmunol.1501903
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5
CpG Oligodeoxynucleotides Alter Lymphocyte and Dendritic Cell Trafficking in Humans
Autor: Xiaochun Li, Suzanne George, Jeffrey L. Kutok, Jeff K. Davies, John S. O. Evans, Thomas Brenn, Donna Neuberg, Jill M. Angelosanto, Jeffrey A. Morgan, Linda Drury, Steven Rivoli, Kate Russell, Robert L. Coffman, W. Nicholas Haining, Paul Sims, George D. Demetri, Patrick Y. Wen, Holger Kanzler, Lee M. Nadler
Publikováno v: Clinical Cancer Research. 14:5626-5634
Purpose: CpG oligodeoxynucleotides (CpG-ODN) are being investigated as cancer vaccine adjuvants because they mature plasmacytoid dendritic cells (PDC) into potent antigen-presenting cells. CpG-ODN also induce PDC to secrete chemokines that alter lymp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a4b29bcdea119f15bc41ded90e7310
https://doi.org/10.1158/1078-0432.ccr-08-0526
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7
Thrombopoietin cooperates with FLT3-ligand in the generation of plasmacytoid dendritic cell precursors from human hematopoietic progenitors
Autor: Bruce R. Blazar, Bianca Blom, Anissa S.H. Chan, Joel M. Sederstrom, Svetlana Antonenko, Xueqing Liang, Wei Chen, Holger Kanzler, Yong Jun Liu
Publikováno v: Blood, 103(7), 2547-2553. American Society of Hematology
Type 1 interferon–producing cells (IPCs), also known as plasmacytoid dendritic cell (DC) precursors, represent the key effectors in antiviral innate immunity and triggers for adaptive immune responses. IPCs play important roles in the pathogenesis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee57b8ee5ff1e0031fa5254e18c0f378
https://doi.org/10.1182/blood-2003-09-3058
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8
Hodgkin and Reed-Sternberg–like cells in B-cell chronic lymphocytic leukemia represent the outgrowth of single germinal-center B-cell–derived clones: potential precursors of Hodgkin and Reed-Sternberg cells in Hodgkin's disease
Autor: Martin-Leo Hansmann, Ralf Küppers, Sabine Helmes, Klaus Rajewsky, Andreas Chott, Holger Kanzler, Hans-Heinrich Wacker
Publikováno v: Europe PubMed Central
In rare cases of B-cell chronic lymphocytic leukemia (B-CLL), large cells morphologically similar to or indistinguishable from Hodgkin/Reed-Sternberg (HRS) cells of Hodgkin's disease (HD) can be found in a background of otherwise typical B-CLL. To te
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::106921e5e7b9e127f7343311ccfb8959
https://doi.org/10.1182/blood.v95.3.1023.003k07_1023_1031
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9
Somatic Mutations Within the Untranslated Regions of Rearranged Ig Genes in a Case of Classical Hodgkin’s Disease as a Potential Cause for the Absence of Ig in the Lymphoma Cells
Autor: Ralf Küppers, Andrea Jox, Martin Kornacker, Holger Kanzler, Heribert Bohlen, Thomas Zander, Volker Diehl, Johannes Irsch, Jürgen Wolf
Publikováno v: Europe PubMed Central
Hodgkin–Reed-Sternberg (H-RS) cells are clonal B cells carrying Ig gene rearrangements. However, in situ hybridization methods failed to demonstrate Ig gene expression in H-RS cells of classical Hodgkin’s disease (HD). Because somatic mutations r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::161c378ac744cfbb4a9dd93a0f34d1c1
https://doi.org/10.1182/blood.v93.11.3964.411k15_3964_3972
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10
Detection of Clonal Hodgkin and Reed-Sternberg Cells With Identical Somatically Mutated and Rearranged VH Genes in Different Biopsies in Relapsed Hodgkin’s Disease
Autor: Ralf Küppers, Martin-Leo Hansmann, Holger Kanzler, Marta Soares, Dieter Kube, Volker Diehl, Martina Vockerodt, Hans Tesch
Publikováno v: Blood. 92:2899-2907
Hodgkin’s disease (HD) represents a malignant lymphoma in which the putative malignant Hodgkin and Reed-Sternberg (H-RS) cells are rare and surrounded by abundant reactive cells. Single-cell analyses showed that H-RS cells regularly bear clonal Ig
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1a3e48652d86d8ceae540488ee39b876
https://doi.org/10.1182/blood.v92.8.2899
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