Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Holger Kühne"'
Autor:
Robert L. Marshall, Georgina S. Lloyd, Amelia J. Lawler, Sarah J. Element, Jaswant Kaur, Maria Laura Ciusa, Vito Ricci, Andreas Tschumi, Holger Kühne, Luke J. Alderwick, Laura J. V. Piddock
Publikováno v:
mBio, Vol 11, Iss 4 (2020)
ABSTRACT Active efflux of antibiotics preventing their accumulation to toxic intracellular concentrations contributes to clinically relevant multidrug resistance. Inhibition of active efflux potentiates antibiotic activity, indicating that efflux inh
Externí odkaz:
https://doaj.org/article/2629c888b070459bbab02735e914fc43
Autor:
Vito Ricci, Georgina S. Lloyd, Maria Laura Ciusa, Andreas Tschumi, Jaswant Kaur, Sarah J Element, Amelia J. Lawler, Robert L Marshall, Luke J. Alderwick, Holger Kühne, Laura J. V. Piddock
Publikováno v:
mBio, Vol 11, Iss 4 (2020)
mBio
mBio
Multidrug-resistant Gram-negative bacteria pose a serious threat to human and animal health. Molecules that inhibit multidrug efflux offer an alternative approach to resolving the challenges caused by antibiotic resistance, by potentiating the activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9faec9d216dc468a70d9309eb1c7e5b
https://journals.asm.org/doi/10.1128/mBio.01340-20
https://journals.asm.org/doi/10.1128/mBio.01340-20
Autor:
Giorgio Ottaviani, Lin Gao, Simona M. Ceccarelli, Ulrike Obst-Sander, Rodolfo Gasser, Xiaolei Zhang, Michael Paul Myers, Sung-Sau So, Bernd Kuhn, Holger Kühne, Shirley Li, Werner Neidhart, Aurelia Conte, Markus G. Rudolph
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:5092-5097
Dual inhibition of fatty acid binding proteins 4 and 5 (FABP4 and FABP5) is expected to provide beneficial effects on a number of metabolic parameters such as insulin sensitivity and blood glucose levels and should protect against atherosclerosis. St
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c41543e55482f6d90cb5fbe74b2971cc
https://doi.org/10.1016/j.bmcl.2016.08.071
https://doi.org/10.1016/j.bmcl.2016.08.071
Autor:
Thierry Lavé, Hans-Joachim Böhm, Ulrike Obst-Sander, David Banner, Lutz Weber, Martin Stahl, Markus A. Riederer, Kurt Hilpert, Hans Peter Wessel, Thomas B. Tschopp, Katrin Groebke Zbinden, Holger Kühne, Leo Alig, Jean Ackermann
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:5344-5352
We describe the structure-based design and synthesis of highly potent, orally bioavailable tissue factor/factor VIIa inhibitors which interfere with the coagulation cascade by selective inhibition of the extrinsic pathway.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6032880aca0a8668a787f6fa99dc00cb
https://doi.org/10.1016/j.bmcl.2005.04.079
https://doi.org/10.1016/j.bmcl.2005.04.079
Autor:
Constantinos G. Panousis, Cornelia Hertel, Holger Kühne, Fabienne Ricklin, Michael B. Otteneder, Nicole A. Kratochwil, Stephan Röver, Uwe Grether, Robert Narquizian, Jens-Uwe Peters, Henrietta Dehmlow, Aurelia Conte, Dominik Hainzl
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(18)
Pyrido pyrimidinones are selective agonists of the human high affinity niacin receptor GPR109A (HM74A). They show no activity on the highly homologous low affinity receptor GPR109B (HM74). Starting from a high throughput screening hit the in vitro ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fbbe6ec77e64b96783df85cf77d00c5
https://pubmed.ncbi.nlm.nih.gov/20724150
https://pubmed.ncbi.nlm.nih.gov/20724150