Zobrazeno 1 - 10
of 177
pro vyhledávání: '"Holger Heyn"'
Autor:
Rebeca Martínez-Hernández, Nuria Sánchez de la Blanca, Pablo Sacristán-Gómez, Ana Serrano-Somavilla, José Luis Muñoz De Nova, Fátima Sánchez Cabo, Holger Heyn, Miguel Sampedro-Núñez, Mónica Marazuela
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Autoimmune thyroid diseases (AITD) such as Graves’ disease (GD) or Hashimoto’s thyroiditis (HT) are organ-specific diseases that involve complex interactions between distinct components of thyroid tissue. Here, we use spatial transcripto
Externí odkaz:
https://doaj.org/article/02a4eb705b064f46963d5354d56b9a18
Autor:
Laura Jiménez-Gracia, Domenica Marchese, Juan C. Nieto, Ginevra Caratù, Elisa Melón-Ardanaz, Victoria Gudiño, Sara Roth, Kellie Wise, Natalie K. Ryan, Kirk B. Jensen, Xavier Hernando-Momblona, Joana P. Bernardes, Florian Tran, Laura Katharina Sievers, Stefan Schreiber, Maarten van den Berge, Tessa Kole, Petra L. van der Velde, Martijn C. Nawijn, Philip Rosenstiel, Eduard Batlle, Lisa M. Butler, Ian A. Parish, Jasmine Plummer, Ivo Gut, Azucena Salas, Holger Heyn, Luciano G. Martelotto
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-36 (2024)
Abstract The use of single-cell technologies for clinical applications requires disconnecting sampling from downstream processing steps. Early sample preservation can further increase robustness and reproducibility by avoiding artifacts introduced du
Externí odkaz:
https://doaj.org/article/d1ab6d70f44f4bfd844fa1f4befa4917
Autor:
Samuel Schäfer, Martin Smelik, Oleg Sysoev, Yelin Zhao, Desiré Eklund, Sandra Lilja, Mika Gustafsson, Holger Heyn, Antonio Julia, István A. Kovács, Joseph Loscalzo, Sara Marsal, Huan Zhang, Xinxiu Li, Danuta Gawel, Hui Wang, Mikael Benson
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-24 (2024)
Abstract Background Ineffective drug treatment is a major problem for many patients with immune-mediated inflammatory diseases (IMIDs). Important reasons are the lack of systematic solutions for drug prioritisation and repurposing based on characteri
Externí odkaz:
https://doaj.org/article/cc1c6e30e6e14966a03d083a086f0b98
Autor:
Juan Blanco-Heredia, Carla Anjos Souza, Juan L. Trincado, Maria Gonzalez-Cao, Samuel Gonçalves-Ribeiro, Sara Ruiz Gil, Dmytro Pravdyvets, Samandhy Cedeño, Maurizio Callari, Antonio Marra, Andrea M. Gazzo, Britta Weigelt, Fresia Pareja, Theodore Vougiouklakis, Achim A. Jungbluth, Rafael Rosell, Christian Brander, Francesc Tresserra, Jorge S. Reis-Filho, Daniel Guimarães Tiezzi, Nuria de la Iglesia, Holger Heyn, Leticia De Mattos-Arruda
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract The interactions between tumor and immune cells along the course of breast cancer progression remain largely unknown. Here, we extensively characterize multiple sequential and parallel multiregion tumor and blood specimens of an index patien
Externí odkaz:
https://doaj.org/article/14cae652f3b14f88b2b7c2b80f375b63
Autor:
Talia Velasco‐Hernandez, Juan L. Trincado, Meritxell Vinyoles, Adria Closa, Alba Martínez‐Moreno, Francisco Gutiérrez‐Agüera, Oscar Molina, Virginia C. Rodríguez‐Cortez, Pau Ximeno‐Parpal, Narcís Fernández‐Fuentes, Paolo Petazzi, Sergi Beneyto‐Calabuig, Lars Velten, Paola Romecin, Raquel Casquero, Fernando Abollo‐Jiménez, Rafael D. de laGuardia, Patricia Lorden, Alex Bataller, Hélène Lapillonne, Ronald W. Stam, Susana Vives, Montserrat Torrebadell, Jose L. Fuster, Clara Bueno, Jean‐Emmanuel Sarry, Eduardo Eyras, Holger Heyn, Pablo Menéndez
Publikováno v:
HemaSphere, Vol 8, Iss 2, Pp n/a-n/a (2024)
Abstract Relapse remains a major challenge in the clinical management of acute myeloid leukemia (AML) and is driven by rare therapy‐resistant leukemia stem cells (LSCs) that reside in specific bone marrow niches. Hypoxia signaling maintains cells i
Externí odkaz:
https://doaj.org/article/5cf2e9d9f3b0488ebf1aab0a7234b697
Autor:
Alba Garrido-Trigo, Ana M. Corraliza, Marisol Veny, Isabella Dotti, Elisa Melón-Ardanaz, Aina Rill, Helena L. Crowell, Ángel Corbí, Victoria Gudiño, Miriam Esteller, Iris Álvarez-Teubel, Daniel Aguilar, M. Carme Masamunt, Emily Killingbeck, Youngmi Kim, Michael Leon, Sudha Visvanathan, Domenica Marchese, Ginevra Caratù, Albert Martin-Cardona, Maria Esteve, Ingrid Ordás, Julian Panés, Elena Ricart, Elisabetta Mereu, Holger Heyn, Azucena Salas
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Ulcerative colitis and Crohn’s disease are chronic inflammatory intestinal diseases with perplexing heterogeneity in disease manifestation and response to treatment. While the molecular basis for this heterogeneity remains uncharacterized,
Externí odkaz:
https://doaj.org/article/91914e5f5fdd496f894dce921d226bce
Autor:
Philipp Janssen, Zane Kliesmete, Beate Vieth, Xian Adiconis, Sean Simmons, Jamie Marshall, Cristin McCabe, Holger Heyn, Joshua Z. Levin, Wolfgang Enard, Ines Hellmann
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-22 (2023)
Abstract Background In droplet-based single-cell and single-nucleus RNA-seq experiments, not all reads associated with one cell barcode originate from the encapsulated cell. Such background noise is attributed to spillage from cell-free ambient RNA o
Externí odkaz:
https://doaj.org/article/aa9dde6a34444a78b997de85197d101b
Autor:
Claudia Garcia-Diaz, Anni Pöysti, Elisabetta Mereu, Melanie P. Clements, Lucy J. Brooks, Felipe Galvez-Cancino, Simon P. Castillo, Wenhao Tang, Gordon Beattie, Lilas Courtot, Sara Ruiz, Federico Roncaroli, Yinyin Yuan, Samuel Marguerat, Sergio A. Quezada, Holger Heyn, Simona Parrinello
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112472- (2023)
Summary: Glioblastoma (GBM) recurrence originates from invasive margin cells that escape surgical debulking, but to what extent these cells resemble their bulk counterparts remains unclear. Here, we generated three immunocompetent somatic GBM mouse m
Externí odkaz:
https://doaj.org/article/2511e84f6c4a4bdfa932c7945c113d09
Autor:
Alba Garrido-Trigo, Ana M. Corraliza, Marisol Veny, Isabella Dotti, Elisa Melón-Ardanaz, Aina Rill, Helena L. Crowell, Ángel Corbí, Victoria Gudiño, Miriam Esteller, Iris Álvarez-Teubel, Daniel Aguilar, M. Carme Masamunt, Emily Killingbeck, Youngmi Kim, Michael Leon, Sudha Visvanathan, Domenica Marchese, Ginevra Caratù, Albert Martin-Cardona, Maria Esteve, Ingrid Ordás, Julian Panés, Elena Ricart, Elisabetta Mereu, Holger Heyn, Azucena Salas
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/b3bab41a702941269b02108c15092e84
Autor:
Irene Robles-Rebollo, Sergi Cuartero, Adria Canellas-Socias, Sarah Wells, Mohammad M. Karimi, Elisabetta Mereu, Alexandra G. Chivu, Holger Heyn, Chad Whilding, Dirk Dormann, Samuel Marguerat, Inmaculada Rioja, Rab K. Prinjha, Michael P. H. Stumpf, Amanda G. Fisher, Matthias Merkenschlager
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Here the authors show inducible genes and enhancers are regulated mainly by transcriptional burst frequency and that this is coordinated in single cells and individual alleles. Cohesin, which is important for inducible gene expression, is largely dis
Externí odkaz:
https://doaj.org/article/fc245dbd45344cc8acb6dc172ee905b9