Výsledky vyhledávání - "Holger Gnann"

Akademický článek

Use of a 'critical difference' statistical criterion improves the predictive utility of the Health Assessment Questionnaire-Disability Index score in patients with rheumatoid arthritis

Autor: Frank Behrens, Michaela Koehm, Eva C. Schwaneck, Marc Schmalzing, Holger Gnann, Gerd Greger, Hans-Peter Tony, Harald Burkhardt

Publikováno v: BMC Rheumatology, Vol 3, Iss 1, Pp 1-9 (2019)

Abstract Background The Health Assessment Questionnaire-Disability Index (HAQ-DI) is used to assess functional status in rheumatoid arthritis (RA), but the change required for meaningful improvements remains unclear. A minimum clinically important di

Externí odkaz: https://doaj.org/article/57d0116d68b5478e9d869ff3d7b5640c

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Sustained improvement in work outcomes in employed patients with rheumatoid arthritis during 2 years of adalimumab therapy: an observational cohort study

Autor: Gerd Greger, Hans-Peter Tony, Holger Gnann, Michaela Koehm, Marc Schmalzing, Eva C. Schwaneck, Harald Burkhardt, Frank Behrens

Publikováno v: Clinical Rheumatology
Clin Rheumatol

Objective The goal of this study was to evaluate the long-term impact of adalimumab therapy on work-related outcomes in employed patients with rheumatoid arthritis (RA). Method We utilized data from an observational cohort of German patients who init

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2355f30c74b672381ad58538b17f2d11
https://doi.org/10.1007/s10067-020-05038-y

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Use of a 'critical difference' statistical criterion improves the predictive utility of the Health Assessment Questionnaire-Disability Index score in patients with rheumatoid arthritis

Autor: Marc Schmalzing, Eva C. Schwaneck, Michaela Koehm, Frank Behrens, Gerd Greger, Hans-Peter Tony, Harald Burkhardt, Holger Gnann

Publikováno v: BMC Rheumatology, Vol 3, Iss 1, Pp 1-9 (2019)
BMC Rheumatology

Background The Health Assessment Questionnaire-Disability Index (HAQ-DI) is used to assess functional status in rheumatoid arthritis (RA), but the change required for meaningful improvements remains unclear. A minimum clinically important difference

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::352c9bb0e5391337837652dfbbc489a1
https://doaj.org/article/57d0116d68b5478e9d869ff3d7b5640c

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Does concomitant methotrexate confer clinical benefits in patients treated with prior biologic therapy? Analysis of data from a noninterventional study of rheumatoid arthritis patients initiating treatment with adalimumab

Autor: Holger Gnann, Gerd Greger, Eva C. Schwaneck, Michaela Koehm, Frank Behrens, Hans-Peter Tony, Harald Burkhardt, Marc Schmalzing

Publikováno v: Medicine

Most studies of methotrexate (MTX) in combination with tumor necrosis factor (TNF) inhibitors have focused on treatment-naive patients with early disease. The goal of this study was to evaluate whether previous biologic therapy influenced the impact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02afa3a76ae1df1e336d9d868398bbfa
https://pubmed.ncbi.nlm.nih.gov/32384515

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Addition or removal of concomitant methotrexate alters adalimumab effectiveness in rheumatoid arthritis but not psoriatic arthritis

Autor: Michaela Koehm, Marc Schmalzing, Gerd Greger, Holger Gnann, H-P Tony, B. Wittig, Eva C. Schwaneck, Frank Behrens, Harald Burkhardt

Publikováno v: Scandinavian journal of rheumatology. 48(5)

Objective: Randomized trials have shown that concomitant methotrexate (MTX) augments the effectiveness of tumour necrosis factor (TNF) inhibitors in rheumatoid arthritis (RA), but its benefit in ps...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4414fb179ac0bb9e1478ba0e36a8ac8
https://pubmed.ncbi.nlm.nih.gov/31311386

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Plný text ve formátu HTML

FRI0396 CHARACTERIZATION OF PATIENTS WITH INFLAMMATORY BOWEL DISEASE IN THE ANKYLOSING SPONDYLITIS COHORT PRIOR AND DURING ADALIMUMAB TREATMENT: DATA FROM A LARGE GERMAN NON-INTERVENTIONAL STUDY

Autor: Gerd Greger, M. Köhm, Marc Schmalzing, Frank Behrens, Holger Gnann, Hans-Peter Tony, Annika Boas, Harald Burkhardt, Eva Christina Schwaneck

Publikováno v: Spondyloarthritis – treatment.

Background Spondylarthritidies (SpA) are characterized by different disease manifestations such as arthritis, enthesitis, dactylitis and associated to concomitant diseases like Inflammatory bowel diseases (IBD) including ulcerative colitis (UC) and c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::081fa2663ec91bba9c8bb855926bd8c7
https://doi.org/10.1136/annrheumdis-2019-eular.5464

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Association of Improvement in Pain With Therapeutic Response as Determined by Individual Improvement Criteria in Patients With Rheumatoid Arthritis

Autor: Frank Behrens, Harald Burkhardt, Gerd Greger, Hans-Peter Tony, Holger Gnann, Michaela Koehm, E. Scharbatke, Marc Schmalzing

Publikováno v: Arthritis Care & Research

Objective To use statistical methods to establish a threshold for individual response in patient-reported outcomes (PROs) in patients with rheumatoid arthritis. Methods We used an analysis of variance model in patients on stable therapy (discovery co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7325e23978182e36399da15dc178abb
https://doi.org/10.1002/acr.22884

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Anti-citrullinated protein antibodies are linked to erosive disease in an observational study of patients with psoriatic arthritis

Autor: Michaela Koehm, Diamant Thaçi, Holger Gnann, Harald Burkhardt, Gerd Greger, B. Wittig, Frank Behrens

Publikováno v: Rheumatology (Oxford, England)

Objective. ACPAs are associated with bone destruction in RA. The aim of this study was to evaluate the association between ACPA and bone destruction in patients with a distinct inflammatory disorder, PsA. Methods. We used baseline data from a large o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acbe365ac0b6d6314b3689226123e1bd
https://doi.org/10.1093/rheumatology/kew229

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Minimal disease activity is a stable measure of therapeutic response in psoriatic arthritis patients receiving treatment with adalimumab

Autor: Eva C. Schwaneck, Frank Behrens, Harald Burkhardt, Michaela Koehm, Gerd Greger, Marc Schmalzing, Holger Gnann, Hans-Peter Tony

Publikováno v: Rheumatology (Oxford, England)

Objective The aim of this study was to evaluate minimal disease activity (MDA) assessments in patients with PsA during routine clinical care. Methods We used data from a multicentre observational study of patients with active PsA who initiated treatm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9adc2b1da0c081c7846543654ee0ae4
https://pubmed.ncbi.nlm.nih.gov/30010891

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Association between Skin and Joint Involvement in Patients with Psoriatic Arthritis Treated with Adalimumab: Analysis of Data from a German Non-Interventional Study

Autor: Diamant Thaçi, Gerd Greger, Bianca Maria Wittig, Frank Behrens, Harald Burkhardt, Rudolf Schopf, Holger Gnann

Publikováno v: Dermatology. 230:213-221

Background: The association between skin and joint manifestations in patients with psoriatic arthritis (PsA) requires further characterization. Objective: We evaluated the association between severity of skin disease and joint involvement and the eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11f2012be34845c7993ab3de37f0074a
https://doi.org/10.1159/000371546

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