Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Holger Erdbrink"'
Autor:
Holger Erdbrink, Elisabeth K. Nyakatura, Susanne Huhmann, Ulla I. M. Gerling, Dieter Lentz, Beate Koksch, Constantin Czekelius
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 9, Iss 1, Pp 2009-2014 (2013)
A practical route for the stereoselective synthesis of (2S,3S)-5,5,5-trifluoroisoleucine (L-5-F3Ile) and (2R,3S)-5,5,5-trifluoro-allo-isoleucine (D-5-F3-allo-Ile) was developed. The hydrophobicity of L-5-F3Ile was examined and it was incorporated int
Externí odkaz:
https://doaj.org/article/f14aec186d9c424f96764c35855678a0
Autor:
Holger Erdbrink, Constantin Czekelius, Ulla I. M. Gerling, Susanne Huhmann, Beate Koksch, Elisabeth K. Nyakatura
Publikováno v:
Journal of Fluorine Chemistry. 175:32-35
Structural modifications of peptides and proteins using fluorinated amino acids provide the opportunity to modulate their biophysical and pharmaceutical properties. Systematic investigations based on model systems that mimic natural protein–protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a155d3137d619c765a4c3f1cbc2998a4
https://doi.org/10.1016/j.jfluchem.2015.03.003
https://doi.org/10.1016/j.jfluchem.2015.03.003
Autor:
Constantin Czekelius, Beate Koksch, Holger Erdbrink, Cosimo Damiano Cadicamo, Mario Salwiczek, Günter Haufe, Stephan L. Grage, Parvesh Wadhwani, Anne S. Ulrich, Malte Behrends, Ulla I. M. Gerling
Publikováno v:
Chem. Sci.. 5:819-830
Fluorinated amino acids can have dramatic effects on protein stability and protein–protein interactions due to the unique stereoelectronic properties of fluorine. Previous approaches to assessing their properties have mainly focused on helical syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a886923ed6231f503663728cfd18591
https://doi.org/10.1039/c3sc52932k
https://doi.org/10.1039/c3sc52932k
Autor:
Holger Erdbrink, Constantin Czekelius
Publikováno v:
Synlett. 24:2383-2388
Starting from fluoroalkylated, optically active acyl oxazolidinones the corresponding di- and trisubstituted butanolides were prepared in enantiomerically pure form. Using a divergent synthetic route highly functionalized fluoroalkylated building blo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b05d9cd24d730ff6fde7478a5923539
https://doi.org/10.1055/s-0033-1339755
https://doi.org/10.1055/s-0033-1339755
Autor:
Holger Erdbrink, Constantin Czekelius
Publikováno v:
ChemInform. 45
Optically active fluoroalkylated acyl oxazolidines are converted into di- and trisubstituted butanolides with high diastereoselectivity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::563097d3a2afb40ea7edd16a2f9e684e
https://doi.org/10.1002/chin.201415110
https://doi.org/10.1002/chin.201415110
Autor:
Ilona Peuser, Constantin Czekelius, Holger Erdbrink, Dieter Lentz, Beate Koksch, Ulla I. M. Gerling
Publikováno v:
ChemInform. 44
A new method for the conjugate hydrotrifluoromethylation of α,β-unsaturated acyl-oxazolidinones and its application in the synthesis of enantiomerically pure diastereomers of trifluorovaline, e.g. intermediates (VII) and (IX), and trifluoroisoleuci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0311c737e1c0c202417fd1e1217d6b3b
https://doi.org/10.1002/chin.201316021
https://doi.org/10.1002/chin.201316021
Autor:
Holger Erdbrink, Dieter Lentz, Ilona Peuser, Beate Koksch, Ulla I. M. Gerling, Constantin Czekelius
Publikováno v:
Organicbiomolecular chemistry. 10(43)
A novel conjugate hydrofluoroalkylation of α,β-unsaturated acyl-oxazolidinones is described. Using this method, enantiomerically pure β-trifluoromethylated amino acids were prepared. Trifluorovaline and trifluoroisoleucine were incorporated into p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b70a624c98b7865904937867e8cc7f2
https://pubmed.ncbi.nlm.nih.gov/23042408
https://pubmed.ncbi.nlm.nih.gov/23042408