Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Holger Deppe"'
Autor:
Michael Erb, Barbara Hoffmann-Enger, Holger Deppe, Michael Soeberdt, Roman H Haefeli, Christian Rummey, Achim Feurer, Nuri Gueven
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e36153 (2012)
Short-chain quinones have been investigated as therapeutic molecules due to their ability to modulate cellular redox reactions, mitochondrial electron transfer and oxidative stress, which are pathologically altered in many mitochondrial and neuromusc
Externí odkaz:
https://doaj.org/article/7250172c67b0469aad609e725b590080
Autor:
Rainer Dr. Uhrig, Hans-Dieter Junker, Sabine Maier, Michael Frank, Oliver Keil, Norbert Müller, Harald Rau, Heiko Mannsperger, Holger Deppe, Siglinde Zepter, Peter Lewandrowski, Cecile Vanier
Publikováno v:
QSAR & Combinatorial Science. 25:1047-1054
A method for the synthesis and quality control of compound collections containing reactive thiol functions was developed. Such libraries form the basis for the construction of chemical microarrays to be used in fragment-based screening. Amino-modifie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c950d6858b6a33c2150861dfca9b948f
https://doi.org/10.1002/qsar.200640125
https://doi.org/10.1002/qsar.200640125
Autor:
Thomas Neumann, Hans-Dieter Junker, Oliver Keil, Klaus Burkert, Holger Ottleben, Jurgen Gamer, Renate Sekul, Holger Deppe, Achim Feurer, Dirk Tomandl, Gunther Metz
Publikováno v:
Letters in Drug Design & Discovery. 2:590-594
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab4928056f600ad96da01d01f28196fe
https://doi.org/10.2174/157018005774717343
https://doi.org/10.2174/157018005774717343
Publikováno v:
Tetrahedron Letters. 44:3939-3942
Two synthetic procedures to enable a straightforward and efficient solid-phase synthesis of 3-aryl-3-oxo-propan amides (β-keto amides) are described and compared. Lithium enolates, which can be obtained by deprotonation of methyl ketones with LiHMDS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6288a876ca8f5f45af0c6064d7653653
https://doi.org/10.1016/s0040-4039(03)00757-3
https://doi.org/10.1016/s0040-4039(03)00757-3
Autor:
Silvia Cerezo-Galvez, Meinolf Thiemann, Meritxell López-Canet, Holger Deppe, Sonja Nordhoff, Victor G. Matassa, Oliver Hill, Achim Feurer, Christian Rummey, Paul J. Edwards
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4201-4203
Modifications of DPP-4 inhibitor 5, that was discovered by structure based design, are described and structure–activity relationships discussed. With analogue 7k one of the most potent non-covalent inhibitors of DPP-4 reported to date (IC50 = 0.38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::503db82633cf0b4a63302b0983499e80
https://doi.org/10.1016/j.bmcl.2009.05.109
https://doi.org/10.1016/j.bmcl.2009.05.109
Publikováno v:
Rapid communications in mass spectrometry : RCM. 16(8)
This paper focuses on the technical aspects of chemical screening from 384-well plate nano-scale single-bead combinatorial libraries. The analytical technique utilized is a combination of capillary liquid chromatography with ultraviolet detection and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2144e9adbe99060d125541705395d009
https://pubmed.ncbi.nlm.nih.gov/11921267
https://pubmed.ncbi.nlm.nih.gov/11921267