Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Holger Paulsen"'
Autor:
Alexandros Vakalopoulos, Frank Wunder, Ingo V. Hartung, Gorden Redlich, Rolf Jautelat, Philipp Buchgraber, Jorma Hassfeld, Alexey V. Gromov, Niels Lindner, Donald Bierer, Jörg Gries, Walter Kroh, Holger Paulsen, Joachim Mittendorf, Dieter Lang, Eva Becker-Pelster, Damian Brockschnieder, Volker Geiss, Volkhart Li, Alexander Straub, Andreas Knorr, Thomas Mondritzki, Hubert Trübel, Marian Raschke, Martina Schaefer, Dirk Thomas, Peter Sandner, Johannes-Peter Stasch, Markus Follmann
Publikováno v:
Journal of Medicinal Chemistry.
Autor:
Thomas Lampe, Winfried Jöntgen, Siegfried Raddatz, Holger Paulsen, Mathias Berwe, Martin Michels, Jochen Krüger, Stefan Weigand, Yolanda Cancho-Grande
Publikováno v:
Organic Process Research & Development. 15:1348-1357
We describe the evolution of a kilogram-scale synthesis of the protected cyclic tripeptide desoxy-biphenomycin B, based on an early discovery route. The retrosynthetic concept included a macrolactamization strategy to build the core ring system of bi
Autor:
Carsten Schmeck, Alexandros Vakalopoulos, Volkhart Min-Jian Li, Hilmar Bischoff, Olaf Weber, Michael Thutewohl, Harry Elias, Klemens Lustig, Holger Paulsen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:488-491
Based on our former development candidate BAY 38-1315, optimization efforts led to the discovery of a novel chemical class of orally active cholesteryl ester transfer protein (CETP) inhibitors. The chromanol derivative 19b is a highly potent CETP inh
Publikováno v:
Organic Process Research & Development. 14:168-173
A highly potent and selective Rho-kinase inhibitor containing a 7-azaindole moiety has been developed at Bayer Schering Pharma. Herein we disclose details of a significantly improved synthesis of the compound in 8.2% overall yield. Key aspects includ
Autor:
Dagmar Klewer, Santiago Figueroa-Pérez, Holger Paulsen, Walter Kroh, Michael Thutewohl, Hartmut Schirok
Publikováno v:
Synthesis. 2007:251-258
Autor:
Harald Labischinski, Jordi Benet-Buchholz, Dieter Habich, Veronica Hellwig, Andreas Schumacher, Heike Brötz-Oesterhelt, Rainer Endermann, Berthold Hinzen, Thomas Lampe, Holger Paulsen, Siegfried Raddatz
Publikováno v:
ChemMedChem. 1:689-693
Autor:
Martin Michels, Holger Paulsen, Cristina Alonso-Alija, Andreas H. Goeller, Hartmut Schirok, Rolf Grosser, Jordi Benet-Buchholz
Publikováno v:
The Journal of Organic Chemistry. 70:9463-9469
[Reaction: see text]. A regioselective and efficient approach toward 6-amino-5-benzoyl-1-substituted 2(1H)-pyridinones by reaction of acyclic ketene aminals with propiolic acid ester was developed. The effect of the solvent and temperature on the reg
Publikováno v:
Synthesis. 1996:141-144
Publikováno v:
Synthesis. 1996:145-148
Autor:
Santiago Figueroa-Pérez, Heike Gielen-Haertwig, Jens-Kerim Ergüden, Adam Nitsche, Rolf Grosser, Lars Bärfacker, Peter Kolkhof, Alexander Hillisch, Joachim Mittendorf, Alexander Kuhl, Heike Heckroth, Holger Paulsen, Karl-Heinz Schlemmer, Johannes Platzek
Publikováno v:
ChemMedChem. 7(8)
Aldosterone is a hormone that exerts manifold deleterious effects on the kidneys, blood vessels, and heart which can lead to pathophysiological consequences. Inhibition of the mineralocorticoid receptor (MR) is a proven therapeutic concept for the ma