Zobrazeno 1 - 10
of 247
pro vyhledávání: '"Holger, Sültmann"'
Autor:
Ermira Lleshi, Toby Milne-Clark, Henson Lee Yu, Henno W. Martin, Robert Hanson, Radoslaw Lach, Sabrina H. Rossi, Anja Lisa Riediger, Magdalena Görtz, Holger Sültmann, Andrew Flewitt, Andy G. Lynch, Vincent J. Gnanapragasam, Charlie E. Massie, Harveer S. Dev
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110330- (2024)
Summary: Prostate cancer screening using prostate-specific antigen (PSA) has been shown to reduce mortality but with substantial overdiagnosis, leading to unnecessary biopsies. The identification of a highly specific biomarker using liquid biopsies,
Externí odkaz:
https://doaj.org/article/e8df49dd662441c084902b69e9243587
Autor:
Tom A.P. Driedonks, Lyle H. Nyberg, Abigail Conte, Zexu Ma, Andrew Pekosz, Eduard Duban, Alexander Tonevitsky, Holger Sültmann, Andrey Turchinovich, Kenneth W. Witwer
Publikováno v:
Heliyon, Vol 10, Iss 3, Pp e24570- (2024)
RNA viruses have been shown to express various short RNAs, some of which have regulatory roles during replication, transcription, and translation of viral genomes. However, short viral RNAs generated from SARS-CoV-1 and SARS-CoV-2 genomic RNAs remain
Externí odkaz:
https://doaj.org/article/7f63fad5ebd44d9b80148db3c47fd3cb
Autor:
Magdalena Görtz, Kilian Baumgärtner, Tamara Schmid, Marc Muschko, Philipp Woessner, Axel Gerlach, Michael Byczkowski, Holger Sültmann, Stefan Duensing, Markus Hohenfellner
Publikováno v:
Digital Health, Vol 9 (2023)
Introduction Artificial intelligence (AI) is increasingly used in healthcare. AI-based chatbots can act as automated conversational agents, capable of promoting health and providing education at any time. The objective of this study was to develop an
Externí odkaz:
https://doaj.org/article/a431bbb24ecb4745a9594e8443750d1c
Autor:
Arlou Kristina Angeles, Petros Christopoulos, Zhao Yuan, Simone Bauer, Florian Janke, Simon John Ogrodnik, Martin Reck, Matthias Schlesner, Michael Meister, Marc A. Schneider, Steffen Dietz, Albrecht Stenzinger, Michael Thomas, Holger Sültmann
Publikováno v:
npj Precision Oncology, Vol 5, Iss 1, Pp 1-12 (2021)
Abstract Targeted kinase inhibitors improve the prognosis of lung cancer patients with ALK alterations (ALK+). However, due to the emergence of acquired resistance and varied clinical trajectories, early detection of disease progression is warranted
Externí odkaz:
https://doaj.org/article/7eb159013a0549caa50c54b83b5b1796
Autor:
Hannah Schindler, Fabienne Lusky, Lea Daniello, Mariam Elshiaty, Lena Gaissmaier, Karolina Benesova, Margarida Souto-Carneiro, Arlou Kristina Angeles, Florian Janke, Florian Eichhorn, Daniel Kazdal, Marc Schneider, Stephan Liersch, Sarah Klemm, Paul Schnitzler, Albrecht Stenzinger, Holger Sültmann, Michael Thomas, Petros Christopoulos
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
IntroductionPD-(L)1 inhibitors (IO) have improved the prognosis of non-small-cell lung cancer (NSCLC), but more reliable predictors of efficacy and immune-related adverse events (irAE) are urgently needed. Cytokines are important effector molecules o
Externí odkaz:
https://doaj.org/article/ef666ed4ec8a4dd9a73f2c5dcfa83e26
Autor:
Samaneh Eickelschulte, Anja Lisa Riediger, Arlou Kristina Angeles, Florian Janke, Stefan Duensing, Holger Sültmann, Magdalena Görtz
Publikováno v:
Cancers, Vol 14, Iss 24, p 6094 (2022)
Current strategies for the clinical management of prostate cancer are inadequate for a precise risk stratification between indolent and aggressive tumors. Recently developed tissue-based molecular biomarkers have refined the risk assessment of the di
Externí odkaz:
https://doaj.org/article/1d76f06b14294c41bba2d6bfbf25bd4f
Autor:
Mei Elsayed, Farastuk Bozorgmehr, Daniel Kazdal, Anna-Lena Volckmar, Holger Sültmann, Jürgen R. Fischer, Mark Kriegsmann, Albrecht Stenzinger, Michael Thomas, Petros Christopoulos
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
BackgroundAnaplastic lymphoma kinase-rearranged non-small-cell lung cancer (ALK+ NSCLC) is a model disease for use of targeted therapies (TKI), which are administered sequentially to maximize patient survival.MethodsWe retrospectively analyzed the fl
Externí odkaz:
https://doaj.org/article/038fbb4cc1074b41b5ddf206f987ab04
Autor:
Steffen Dietz, Petros Christopoulos, Zhao Yuan, Arlou Kristina Angeles, Lisa Gu, Anna-Lena Volckmar, Simon J. Ogrodnik, Florian Janke, Chiara Dalle Fratte, Tomasz Zemojtel, Marc A. Schneider, Daniel Kazdal, Volker Endris, Michael Meister, Thomas Muley, Erika Cecchin, Martin Reck, Matthias Schlesner, Michael Thomas, Albrecht Stenzinger, Holger Sültmann
Publikováno v:
EBioMedicine, Vol 62, Iss , Pp 103103- (2020)
Background: Targeted therapies (TKI) have improved the prognosis of ALK-rearranged lung cancer (ALK+ NSCLC), but clinical courses vary widely. Early identification and molecular characterisation of treatment failure have key importance for subsequent
Externí odkaz:
https://doaj.org/article/35543e5f53e748e782b1be948db8ee4b
Autor:
Magdalena Görtz, Joanne Nyaboe Nyarangi-Dix, Lars Pursche, Viktoria Schütz, Philipp Reimold, Constantin Schwab, Albrecht Stenzinger, Holger Sültmann, Stefan Duensing, Heinz-Peter Schlemmer, David Bonekamp, Markus Hohenfellner, Jan Philipp Radtke
Publikováno v:
Cancers, Vol 14, Iss 4, p 886 (2022)
Multiparametric magnetic resonance imaging (mpMRI) and MRI/ultrasound fusion-targeted prostate biopsy (FB) have excellent sensitivity in detecting significant prostate cancer (sPC). FB platforms can be distinguished by rigid (RTB) or elastic image re
Externí odkaz:
https://doaj.org/article/7a61ccef97b64058896a48b8b6eddccb
Autor:
Sabrina Grasse, Matthias Lienhard, Steffen Frese, Martin Kerick, Anne Steinbach, Christina Grimm, Michelle Hussong, Jana Rolff, Michael Becker, Felix Dreher, Uwe Schirmer, Stefan Boerno, Anna Ramisch, Gunda Leschber, Bernd Timmermann, Christian Grohé, Heike Lüders, Martin Vingron, Iduna Fichtner, Sebastian Klein, Margarete Odenthal, Reinhard Büttner, Hans Lehrach, Holger Sültmann, Ralf Herwig, Michal R. Schweiger
Publikováno v:
Genome Medicine, Vol 10, Iss 1, Pp 1-16 (2018)
Abstract Background Non-small cell lung cancer (NSCLC) is the most common cause of cancer-related deaths worldwide and is primarily treated with radiation, surgery, and platinum-based drugs like cisplatin and carboplatin. The major challenge in the t
Externí odkaz:
https://doaj.org/article/84b7234bcdf146459a94256898e040dd